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BIOMARKER:
FLT3 mutation + NPM1 mutation
i
Other names:
Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23, FLT3, Fms Related Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, Fms-Like Tyrosine Kinase 3, CD135, FLK-2, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fetal Liver Kinase 2
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Entrez ID:
2322
;
4869
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
NPM-RARA fusion (2)
NPM1-NR4A3 fusion (2)
ETV6-FLT3 fusion (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
NPM-ALK fusion (1)
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
NPM-RARA fusion (2)
NPM1-NR4A3 fusion (2)
ETV6-FLT3 fusion (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
NPM-ALK fusion (1)
›
Associations
(4)
News
Trials
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Latest
almost2years
☝🏼"Cup-like" blasts in AML with strong association to NPM1 and FLT3 mutations ✌🏼generally demonstrates a normal karyotype, high D-dimer levels, and negative CD34 and HLA-DR expression #hemepath #pathboards #pathoutpic (@SueEPig)
almost 2 years ago
FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1) • CD34 (CD34 molecule)
|
FLT3 mutation • NPM1 mutation • FLT3 mutation + NPM1 mutation
over2years
#LLMCongress2021 | @groboz @weillcornell AZA as maintenance significantly improved OS and RFS independent of NPM1 and FLT3 mutation status, without meaningful differences in QOL, and had a higher rate of MRD response and duration of MRD negativity #leusm (@AML_Hub)
over 2 years ago
Clinical • Minimal residual disease
|
FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1)
|
FLT3 mutation • NPM1 mutation • FLT3 mutation + NPM1 mutation
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