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    BIOMARKER:

    FLT3 mutation + NPM1 mutation

    i
    Other names: Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23, FLT3, Fms Related Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, Fms-Like Tyrosine Kinase 3, CD135, FLK-2, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fetal Liver Kinase 2
    Entrez ID:
    2322; 4869
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    ☝🏼"Cup-like" blasts in AML with strong association to NPM1 and FLT3 mutations ✌🏼generally demonstrates a normal karyotype, high D-dimer levels, and negative CD34 and HLA-DR expression #hemepath #pathboards #pathoutpic (@SueEPig)
    FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1) • CD34 (CD34 molecule)
    |
    FLT3 mutation • NPM1 mutation • FLT3 mutation + NPM1 mutation
    over2years
    #LLMCongress2021 | @groboz @weillcornell AZA as maintenance significantly improved OS and RFS independent of NPM1 and FLT3 mutation status, without meaningful differences in QOL, and had a higher rate of MRD response and duration of MRD negativity #leusm (@AML_Hub)
    Clinical • Minimal residual disease
    |
    FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1)
    |
    FLT3 mutation • NPM1 mutation • FLT3 mutation + NPM1 mutation