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BIOMARKER:
ER Y537S
i
Other names:
ESR1, Era, ESR, NR3A1, ER, ER beta
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Entrez ID:
2099
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
AKT1 mutation + ER negative (1)
AKT1 mutation + ER positive (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN deletion + ER positive (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
AKT1 mutation + ER negative (1)
AKT1 mutation + ER positive (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN deletion + ER positive (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
›
Associations
(17)
News
Trials
Search handles
@LGerratana
Search handles
@LGerratana
Filter by
Latest
1year
New data supporting a deeper #ESR1 variant characterization in #BreastCancer. Y537S is resistant to #SERD #SERM due to stable conformation and activity. L536 shows varying sensitivity, greatest resistance: AZD9833 GDC-0810 RAD1901 #PrecisionMedicine #bcsm https://t.co/5llI1gngbs (@LGerratana)
1 year ago
ER (Estrogen receptor)
|
ER Y537S
|
Orserdu (elacestrant) • camizestrant (AZD9833) • brilanestrant (GDC-0810)
2years
If you have ER+ metastatic breast cancer with an ESR1 mutation Y537S, @CancerCenter this phase I/2 trial offers a new oral selective estrogen receptor covalent antagonist (no more than 1 prior line of chemo) https://t.co/dTCNw4Cl3w. @ErikaHamilton9 (@eugeneahn)
2 years ago
ER (Estrogen receptor)
|
ER mutation • ER Y537S • ESR1 mutation
almost3years
In the phase 2, stable disease was seen in 43% of people and a partial response in 17%. Those with the Y537S ESR1 mutation had the highest clinical benefit rate, although those with D538G also showed some benefit. #ASCO21 #bcsm (@stage4kelly)
almost 3 years ago
Clinical • P2 data
|
ER (Estrogen receptor)
|
ER mutation • ER Y537S • ER D538G
over3years
H3B-6545はESR1 Y537S変異やCDK4/6阻害薬・フルベストラントを含む治療歴の多いER+HER2-転移乳癌に対し有望【SABCS2020】:がんナビ サンアントニオ乳がんシンポジウムからのニュースです。今後の開発に期待します。 #乳がん #SABCS20 https://t.co/2VkXfo0c3i (@cancer_navi)
over 3 years ago
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • CDK4 (Cyclin-dependent kinase 4)
|
ER Y537S
|
H3B-6545
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