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BIOMARKER:
EML4-ALK G1202R
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor, EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120
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Entrez ID:
238
;
27436
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK positive (73)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
ALK positive (73)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
›
Associations
(2)
News
Trials
Search handles
@StephenVLiu
Search handles
@StephenVLiu
Filter by
Latest
2years
Report in @ESMO_Open on liquid biopsy results post TKI therapy for 116 pts with #ALK fusion+ NSCLC. G1202R resistance mutation more common in EML4-ALK fusion variant 3, L1196M more in v1. More compound and complex mutations seen with use of multiple TKIs. https://t.co/ID201mkX4C (@StephenVLiu)
2 years ago
Clinical • Liquid biopsy
|
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
EML4-ALK fusion • ALK fusion • ALK G1202R • EML4-ALK L1196M • ALK L1196M • EML4-ALK G1202R
over3years
Zhu et al. reported a novel EML4-ALK v3 G1202R/S1206Y in cis double mutation resistant to #lorlatinib & described 3D modeling of #resistance & relevant literature review. https://t.co/PgdneffxIL @ViolaWZhu @MNagasaka @jjeancui @oncoOuLungCA @OncologyAdvance #JTOCRR #LCSM #ALK (@IASLC)
over 3 years ago
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
ALK G1202R • ALK S1206Y • EML4-ALK G1202R • EML4-ALK S1206Y
|
Lorbrena (lorlatinib)
over3years
Zhu et al. reported a novel EML4-ALK v3 G1202R/S1206Y in cis double mutation resistant to #lorlatinib & described 3D modeling of #resistance & relevant literature review. https://t.co/BwXUkjY5EF @ViolaWZhu @MNagasaka @jjeancui @oncoOuLungCA @OncologyAdvance #JTOCRR #LCSM #ALK (@JTOonline)
over 3 years ago
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
ALK G1202R • ALK S1206Y • EML4-ALK G1202R • EML4-ALK S1206Y
|
Lorbrena (lorlatinib)
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