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BIOMARKER:
EGFR overexpression
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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News alerts, weekly reports and conference planners
Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Associations
(34)
News
Trials
Search handles
@AndresFCardonaZ
@StephenVLiu
@tpjmd
Search handles
@AndresFCardonaZ
@StephenVLiu
@tpjmd
Filter by
Latest
over1year
Report of oleclumab (anti-CD73) plus osimertinib in #EGFR NSCLC @JTOonline. CD73 often overexpressed in EGFR mutant NSCLC. Explored post 1G/2G TKI, T790M negative, osi naive. At dose level 2, RR 12% with mPFS 7.4m, mOS 25m. https://t.co/we5zEtPi4r (@StephenVLiu)
over 1 year ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR T790M • EGFR overexpression • CD73 overexpression • EGFR T790M negative • CD73 expression
|
Tagrisso (osimertinib) • oleclumab (MEDI9447)
almost2years
Hypothesis-generating: Addition of afatanib to patients c/ EGFR over-expressing met gastric cancer should be explored. Addition of IO to chemo (or in place of chemo) for periop Rx of resectable gastric cancer should be explored, esp among pts c/ MSI-H/dMMR/hPDL1CPS tumors. (@tpjmd)
almost 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • MSI (Microsatellite instability)
|
MSI-H/dMMR • EGFR expression • EGFR overexpression • MET overexpression • MET expression
almost3years
Combined FGFR and Akt pathway inhibition abrogates growth of FGFR1 overexpressing EGFR-TKI-resistant NSCLC cells - Interesting and productive old collaboration (@AndresFCardonaZ)
almost 3 years ago
EGFR (Epidermal growth factor receptor) • FGFR1 (Fibroblast growth factor receptor 1)
|
EGFR overexpression • FGFR1 overexpression
over3years
First, #VEGF is highly expressed in #EGFR mutant cell lines (HCC827, H3255) and TKI therapy drops VEGF mRNA while in resistant setting (H1975 with T790M), erlotinib has no impact on high VEGF levels. In EGFRmt NSCLC, VEGF secretion is EGFR dependent. (@StephenVLiu)
over 3 years ago
Preclinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR T790M • EGFR expression • EGFR overexpression • EGFR H1975
|
erlotinib
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