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    BIOMARKER:

    EGFR mutation + KRAS mutation

    i
    Other names: KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog, EGFR, ERBB, ERBB1, Epidermal growth factor receptor
    Entrez ID:
    1956; 3845
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    3years
    .@NickRohsMD discusses KRAS and EGFR mutations in #NSCLC https://t.co/U4ponQjzrl via @targetedonc @IcahnMountSinai (@TischCancer)
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS mutation • EGFR mutation • EGFR mutation + KRAS mutation
    over3years
    Important to learn of the outcome in KRAS and BRAF mutated NSCLC with sequencing use of IO and TKI, to contrast w/ what we now know in EGFR-mutants of the IO preexposure risk of pnuemonitis toxicity in subsequent EGFR-TKI use (@PatrickCMa1)
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
    |
    KRAS mutation • EGFR mutation • BRAF mutation • EGFR mutation + KRAS mutation
    over3years
    Enjoyed the impt NACLC20 Oral Abstract on Real-world PFS in oncogene driver-mutated NSCLC treated w single-agent IO. KRAS mutations stand out as different from EGFR/ALK, but more similar to BRAF mutants. Limitation: Line of Rx not known. (@PatrickCMa1)
    Clinical • Real-World Evidence
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase)
    |
    KRAS mutation • BRAF mutation • ALK mutation • EGFR mutation + KRAS mutation
    over3years
    Our effort on understanding lung cancer genomes of patients from Latin America: ancestry-specific germline variants increase the risk of EGFR/KRAS-mutant lung cancer in non-smokers. @meyersonlab @AndresFCardonaZ @ogarrieta #ancestry #lungcancer https://t.co/qaOmPK13dO (@CarrotJian)
    Clinical
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS mutation • EGFR mutation • EGFR mutation + KRAS mutation