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BIOMARKER:
EGFR L858R
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR mutation (196)
EGFR T790M (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
EGFR L861Q (23)
EGFR C797S (22)
EGFR exon 21 mutation (20)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
EGFR wild-type + ALK wild-type (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + KRAS mutation (4)
EGFR mutation + PIK3CA mutation (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + BRAF V600 (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
EGFR mutation (196)
EGFR T790M (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
EGFR L861Q (23)
EGFR C797S (22)
EGFR exon 21 mutation (20)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
EGFR wild-type + ALK wild-type (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + KRAS mutation (4)
EGFR mutation + PIK3CA mutation (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + BRAF V600 (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
›
Related tests:
FoundationOne® CDx (110)
Guardant360® CDx (54)
FoundationOne® Liquid CDx (20)
cobas® EGFR Mutation Test v2 (13)
therascreen® EGFR RGQ PCR Kit (5)
OncoReveal™ Dx Lung and Colon Cancer Assay (O/RDx-LCCA)
Target Selector™ EGFR Mutation Assay
FoundationOne® CDx (110)
Guardant360® CDx (54)
FoundationOne® Liquid CDx (20)
cobas® EGFR Mutation Test v2 (13)
therascreen® EGFR RGQ PCR Kit (5)
OncoReveal™ Dx Lung and Colon Cancer Assay (O/RDx-LCCA)
Target Selector™ EGFR Mutation Assay
Associations
(90)
News
Trials
Search handles
@ADesaiMD
@APassaroMD
@BijoyTelivala
@CharuAggarwalMD
@DevikaDasMD
@DrChoueiri
@DrHaigentz
@DrSteveMartin
@PatelOncology
@StephenVLiu
@Tony_Calles
@VivekSubbiah
@christine_lovly
@dplanchard
@ksivaprasadk
@oncologician
Search handles
@ADesaiMD
@APassaroMD
@BijoyTelivala
@CharuAggarwalMD
@DevikaDasMD
@DrChoueiri
@DrHaigentz
@DrSteveMartin
@PatelOncology
@StephenVLiu
@Tony_Calles
@VivekSubbiah
@christine_lovly
@dplanchard
@ksivaprasadk
@oncologician
Filter by
Latest
10ms
ASCO 2023 Plenary abstract LBA3 Dr Roy Herbst lead author of the ADAURA study in EGFRm (ex19del/L858R) stage IB, II or IIIA NSCLC; overall survival benefit of 51% reduction in risk of death in the overall population. #ASCO2023 #precisiononcology #PoetOncology #targetedtreatment (@POETOncology)
10 months ago
Clinical • Late-breaking abstract
|
EGFR L858R • EGFR exon 19 deletion
12ms
It’s not enough to say “EGFR mutation” there are different therapies depending on ex19/L858R vs exon20ins. Have to provide both the street (gene) name and full address as I tell my trainees. Continuation of phenomenal mNSCLC session by @riess_md @HwakeleeMD #MedIQ23ASCO (@MedIQCME)
12 months ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
12ms
It’s not enough to say “EGFR mutation” there are different therapies depending on ex19/L858R vs exon20ins. Have to provide both the street (gene) name and full address as I tell my trainees. Continuation of phenomenal mNSCLC session by @riess_md @HwakeleeMD (@PatelOncology)
12 months ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
12ms
3/ 📌 On Dec 18, 2020, the @FDAOncology gave a thumbs up 👍 to osimertinib for adjuvant therapy post tumor resection in NSCLC patients with EGFR exon 19 deletions or exon 21 L858R mutations. ADAURA study showed ➡️ Median DFS not reached vs 19.6 months on placebo (HR 0.17,… https://t.co/zLg1uyLDCc (@ADesaiMD)
12 months ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
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Tagrisso (osimertinib)
12ms
NSCLC with an #EGFR exon 20 insertion mutation is different from exon 19 deletion and exon 21 L858R! Drs. Byoung-Chul Cho and @charocampelo describe their approach and Marcia Horn @Exon20Group provides perspective in this episode of #LungCancerConsidered https://t.co/i16OujxoC7 (@StephenVLiu)
12 months ago
EGFR exon 20
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR exon 20 insertion • EGFR exon 20 mutation • EGFR L858R + EGFR exon 19 deletion
1year
Dr. Pasi Janne discusses the current standards with #EGFR NSCLC. Varies by mutation - osimertinib for del19 and L858R but afatinib for uncommon (though osi also active) and amivantamab or mobocertinib for ex20ins. Will we see a shift in the near future to SOC? #RomeLung23 (@StephenVLiu)
1 year ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
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Tagrisso (osimertinib) • Gilotrif (afatinib) • Rybrevant (amivantamab-vmjw) • Exkivity (mobocertinib)
1year
2/ @LeXiuning @MDAndersonNews on EGFR mutations: ▪️EGFR mutations ~10-20% NSCLC pts in Europe/N America, & up to 50% of patients in Asia ▪️Exon 19 del & exon 21 L858R most common (~85-90%) ▪️🔑 Most frequent uncommon mutations to know: G719X, S768I, L861Q, & exon 20 insertions (@esinghimd)
1 year ago
Clinical
|
EGFR (Epidermal growth factor receptor)
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EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L861Q • EGFR G719X • EGFR S768I
1year
My mom's mNSCLC just progressed after 4 years on 1st line osimertinib. A new biopsy showed the original L858R mutation at 6.5%, EGFR copy number 5.3x. What is the best treatment strategy now? Gefitinib cetuximab combination? Thanks. (@love_kb_jun)
1 year ago
Biopsy
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EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
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Erbitux (cetuximab) • Tagrisso (osimertinib) • gefitinib
over1year
🦄 Osimertinib in non-exon 19 deletion or L858R EGFR mutations (excluded from FLAURA trial) Important issue, as they represent ≈ 20% of EGFR mutations in the clinic. Thrilled to participate in this study now @IASLC 🔝 as Editor’s choice @JTOonline #LCSM https://t.co/adB3FJKezV (@Tony_Calles)
over 1 year ago
EGFR (Epidermal growth factor receptor)
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EGFR mutation • EGFR L858R • EGFR exon 19 deletion
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Tagrisso (osimertinib)
over1year
Promising efficacy of 4th generation EGFR TKI after 3 weeks in NSCLC pt EGFR L858R, T790M, C797S mutations in progression post gefitinib, osimertinib and amivantamab...to be continued @GustaveRoussy @CICThoraciques (@dplanchard)
over 1 year ago
Clinical
|
EGFR (Epidermal growth factor receptor)
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EGFR mutation • EGFR L858R • EGFR T790M • EGFR C797S
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Tagrisso (osimertinib) • gefitinib • Rybrevant (amivantamab-vmjw)
over1year
Nice talk on EGFR (it’s not enough to just name the street anymore, you have to say the whole address- exon 19 del, exon 20 insertion, L858R etc) in mNSCLC by @MdCurioni @LungSummit (@PatelOncology)
over 1 year ago
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR exon 19 deletion
almost2years
🧵11 We analyze a large cohort (n=121) of putative tSCLC w/ driver mut typically found in NSCLC ➡️EGFR (ex19del > L858R in SCLC cases!) ➡️ALK ➡️ROS1 ➡️RET ➡️NTRK Need for rebiopsy of all driver+ NSCLC to look for SCLC @EGFRResisters @ALKLungCancer @ros1cancer @RetRenegades (@christine_lovly)
almost 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK (Neurotrophic receptor tyrosine kinase)
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EGFR L858R • EGFR exon 19 deletion
almost2years
F/66y ,good PS Stg IV Lung with brain mets SRS to brain Exon 21 L858R mut along with Her2 amplification on NGS How to Rx? @LeciaSequist @christine_lovly @DrSteveMartin @drgandara @geoff_oxnard @Alfdoc2 @CharuAggarwalMD @JustinGainor @PatelOncology @VivekSubbiah @Dr_R_Kurzrock (@oncologician)
almost 2 years ago
Next-generation sequencing
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HER-2 (Human epidermal growth factor receptor 2)
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HER-2 amplification • EGFR L858R
almost2years
Masterclass in EGFRx20ins NSCLC with @RamalingamMD discussing role for mobocertinib. Not enough to name the gene street anymore (EGFR), we need to house address (exon 19, exon 20ins, L858R, etc). Can determine by NGS either cfDNA or tissue. @OMIonc (@PatelOncology)
almost 2 years ago
Next-generation sequencing
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR exon 20 insertion
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Exkivity (mobocertinib)
almost2years
#ASCO22 Abstract #9006 updates CHRYSALIS-2 cohort of amivantamab + lazertinib in #EGFR NSCLC (del19/L858R) post-osimertinib, post-chemo. In 50pts immediately post osi, RR 36%. In more heavily pretreated (n=56), RR 29%. Full cohort to be reported by Dr. Catherine Shu. #LCSM (@StephenVLiu)
almost 2 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
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Tagrisso (osimertinib) • Rybrevant (amivantamab-vmjw) • Leclaza (lazertinib)
2years
AENEAS: Randomized 1L Phase III Trial of Aumolertinib Vs. Gefitinib in Met. NSCLC With EGFR Ex 19 Deletion/L858R Mut | @JCO_ASCO I can’t keep up with all new EGFRi! @NarjustDumaMD @DrMarkAwad @CharuAggarwalMD https://t.co/q4IroZuBe9 (@DrChoueiri)
2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR exon 19 deletion
|
gefitinib • Ameile (aumolertinib)
2years
⭐️ Another new drug for EGFR ✅AUMOLERTINIB 👉🏼AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as 1st-Line Therapy for Locally Advanced or Metastatic NSCLC With EGFR Exon 19 Deletion or L858R Mutations 🧬🎯@JCO_ASCO @OncoAlert https://t.co/ko2T8sUFLh (@VivekSubbiah)
2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
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gefitinib • Ameile (aumolertinib)
2years
Not sure why PD-L1 <1% is pos and PD-L1>50% is neg. Different than IMP010 & from what we know from other studies. If approved wonder if adjuvant NSCLC landscape,after 4 cycles of platinum: EGFRmt (x19,L858R): osi PD-L1<1%: pembro PD-L1 1-49%: atezo or pembro PD-L1 >50%: atezo (@PatelOncology)
2 years ago
Clinical
|
PD-L1 (Programmed death ligand 1)
|
EGFR L858R
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Keytruda (pembrolizumab) • Tecentriq (atezolizumab)
2years
#TTLC22 Dr. @politikaterina reviews acquired resistance to #EGFR TKIs. Similar mechanisms of resistance to osimertinib and 1G/2G TKIs but different frequencies. Interestingly, some resistance mutations seem allele specific - C797S more with del19 and L718 more in L858R. #LCSM (@StephenVLiu)
2 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR C797S
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Tagrisso (osimertinib)
over2years
Interesting discussion here at #gotoWLC regarding situations with multiple drivers. What do you do with a FISH positive ROS1 and EGFR L858R? What do you do with 2 pathogenic EGFR? The panel is leaning into @JoelNealMD for guidance. #LCSM (@KellyMercierPh1)
over 2 years ago
EGFR (Epidermal growth factor receptor) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
EGFR L858R • ROS1 positive
over2years
Mostly included common #EGFR mutations (del19, L858R) but ~5% others. About 35% of patients had brain metastases. Prior TKI required, 30% had two lines of TKI therapy. #ESMOasiaweek21 (@StephenVLiu)
over 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
over2years
Enrolled 234 pts with EGFR del19 or L858R. All had an R0 resection, 99% with lobectomy, balanced by stage (40% stage II, 60% stage III). Received gefitinib 250mg qday x 2y or 4 cycles of cisplatin + vinorelbine. More G3+ tox with chemo, more rash/diarrhea with gefitinib. #LCSM (@StephenVLiu)
over 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
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cisplatin • gefitinib • vinorelbine tartrate
over2years
In most #EGFR NSCLC studies, exon 19 deletion associated with better outcomes than exon 21 L858R. This single center analysis explores co-mutations in tumor suppressor genes between the two. Could KEAP1 alterations be playing a role in EGFR mutant NSCLC? https://t.co/FTMW7hF1uV (@StephenVLiu)
over 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • KEAP1 (Kelch Like ECH Associated Protein 1)
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EGFR mutation • EGFR L858R • EGFR exon 19 deletion • KEAP1 mutation
over2years
#ESMO21 Symposium on #EGFR mutations with Drs. @dplanchard @AlexSpiraMDPhD, Keith Kerr, and Johan Vansteenkiste highlights the differences between del19, L858R, and exon 20 insertions and the evolving treatment landscape. Increasingly complex and increasingly effective. #LCSM (@StephenVLiu)
over 2 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R
over2years
#ESMO21 Here, 60/40 split of #EGFR del19/L858R. No difference here in PFS. mPFS 20m with osi and 22m with osi/bev. Overall PFS HR 0.862 by BICR. Interesting to contrast to BEVERLY and other erlotinib-based studies. #LCSM @myESMO (@StephenVLiu)
over 2 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
|
erlotinib
over2years
#ESMO21 #LCSM Dr Piccirillo presenting thePh3 BEVERLY-trial: Italian random open-label, trial of bevacizumab (BEV) plus erlotinib (E) vs E alone as 1L treat for EGFR-mut a NSCLC. 180 pts random: 80 vs 80 55% of pts had ex19Del and 41% L858R mutation (@APassaroMD)
over 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR exon 19 deletion
|
Avastin (bevacizumab) • erlotinib
almost3years
Small sample size but interesting report in @JTOonline on 4 patients with de novo T790M/L858R #EGFR NSCLC with acquired resistance to osimertinib. Mechanisms of resistance identified: C797S, C797S/L798I, #MET amp and MTOR L1433S. #LCSM @IASLC @OncoAlert https://t.co/7mg1KB0n8H (@StephenVLiu)
almost 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR T790M • EGFR C797S
|
Tagrisso (osimertinib)
3years
Need help with a #lungcancer patient 66 y/o F , non smoker Stage4- pleural effusion adenoca 2 EGFR mutations EXON 20 c.2303G>T (p.S768I) Exon 21: c.2573T>G (p.L858R) Tx options? Tagrisso? @PatelOncology @JackWestMD @HosseinBorghaei (@BijoyTelivala)
3 years ago
Clinical • Pleural effusion
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR S768I
|
Tagrisso (osimertinib)
3years
@drharshvardhan @ProfBhargava corona virus behaving like cancer as regards mutations.Egfr L858R lung cancer when treated with Gefirinib, under pressure evolves and develops second mutation T790M after 10 months.Virus evades vaccine by developing new mutants but within weeks. (@drshyam_aggarwa)
3 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR T790M
3years
It'd be interesting to know the cfDNA VAF of EGFR L858R compared to the others (N-myc amp, p53, PI3KCA), which may shed light on how much lung adeno v. small cell clonality you have. I agree Chemo-Osi sounds more appealing than Chemo-IO (@ChadPecot)
3 years ago
MYCN (MYCN Proto-Oncogene BHLH Transcription Factor)
|
EGFR L858R
over3years
Phase I trial of Osi + Ram in EGFR T90M EGFR MT #NSCLC, 25 pts treated, including those with brain mets. On-therapy loss of EGFR Ex 19 del/L858R, correlated with longer PFS, but on-treatment loss of T790M did not. @CCR_AACR @HelenaYu923 @dplanchard @http://bit.ly/2LpwqWD (@CharuAggarwalMD)
over 3 years ago
Clinical • P1 data
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R • EGFR T790M
over3years
The day of @US_FDA approvals! now osimertinib for ADJUVANT therapy in high-risk NSCLC & EGFR ex. 19 deletions/ ex. 21 L858R mutations test. Efficacy based on ADURA trial (DFS HR 0.17) @JackWestMD @LeciaSequist @DrMarkAwad @drgandara @n8pennell @OncoAlert https://t.co/pca5KJC6y0 (@DrChoueiri)
over 3 years ago
Clinical • FDA event
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
|
Tagrisso (osimertinib)
over3years
60/Male Adenocarcinoma of lung pT3N2 (max 4.7cm), R0 Stage IIIB LVI present EGFR L858R+ Took Adj Chemo with Pem+Carbo 4 cycles(Yes Carbo!) Later, Recieved Adj RT (60Gy) Came for adjuvant Osimertinib opinion What is your opinion? @JackWestMD @sujithonco @ChowdaryStalin (@ksivaprasadk)
over 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
|
Tagrisso (osimertinib)
over3years
Really should be clinical trial but if not Chemo/ RT for N2 multistation disease with EGFR L858R and close follow up. Discuss PACIFIC with the caveats clearly explained and honestly would recommend against it as it really does not represent this population well at all 🤷🏽♀️#lcsm (@DevikaDasMD)
over 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
over3years
A colleague asked this Q- i don’t know the answer. It is a Flaw-ADAURA Q. Can #LCSM help? Elderly fit pt with N2 multistation + NSCLC, EGFR L858R. What do we do? @LeciaSequist @n8pennell @JackWestMD @benlevylungdoc @PatelOncology @Alfdoc2 and if he still talks to me @StephenVLiu (@DrSteveMartin)
over 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
almost4years
#ASCO20 The phase III #ADAURA trial included patients with resected stage IB, II or IIIA NSCLC (with or without adjuvant chemotherapy) with an #EGFR deletion 19 or L858R mutation. CNS imaging and post-op CT required before entry. #OncoAlert #LCSM (@StephenVLiu)
almost 4 years ago
Clinical • P3 data
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
4years
Just got call for input on patient with inoperable St IIIA NSCLC who is TOO SCARED to leave the house for CRT!! Turns out tumor is EGFR L858R pos and colleague is considering Osimertinib. Is palliative but I can’t blame him. Expect others have similar challenging cases. (@DrHaigentz)
4 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR L858R
|
Tagrisso (osimertinib)
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