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BIOMARKER:
EGFR L718Q
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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News alerts, weekly reports and conference planners
Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR exon 19 deletion (79)
EGFR amplification (52)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
EGFR exon 19 deletion (79)
EGFR amplification (52)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
›
Associations
(3)
News
Trials
Search handles
@StephenVLiu
Search handles
@StephenVLiu
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Latest
almost4years
#OncoAlert Report on a ph I/II trial of first line osimertinib + gefitinib in #EGFR NSCLC by Dr. Rotow. Will prevention of 2nd site mutations T790M, L718Q, C797S seen in vitro translate to more benefit? Report on 27 patients shows feasibility (though 11% G3 diarrhea). #OncoAlert (@StephenVLiu)
almost 4 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR C797S • EGFR L718Q
|
Tagrisso (osimertinib) • gefitinib
almost4years
#OncoAlert Great correlatives to complement this trial including ctDNA analysis. Persistent detectable EGFR ctDNA at 6 weeks had worse PFS than those who cleared (9.8m vs 16.2m) and worse OS. Authors also characterized resistance (C797S, L718Q, squamous transformation). #LCSM (@StephenVLiu)
almost 4 years ago
EGFR (Epidermal growth factor receptor)
|
EGFR C797S • EGFR L718Q
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