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    BIOMARKER:

    EGFR L718Q

    i
    Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
    Entrez ID:
    1956
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    almost3years
    #OncoAlert Report on a ph I/II trial of first line osimertinib + gefitinib in #EGFR NSCLC by Dr. Rotow. Will prevention of 2nd site mutations T790M, L718Q, C797S seen in vitro translate to more benefit? Report on 27 patients shows feasibility (though 11% G3 diarrhea). #OncoAlert (@StephenVLiu)
    EGFR (Epidermal growth factor receptor)
    |
    EGFR C797S • EGFR L718Q
    |
    Tagrisso (osimertinib) • gefitinib
    almost3years
    #OncoAlert Great correlatives to complement this trial including ctDNA analysis. Persistent detectable EGFR ctDNA at 6 weeks had worse PFS than those who cleared (9.8m vs 16.2m) and worse OS. Authors also characterized resistance (C797S, L718Q, squamous transformation). #LCSM (@StephenVLiu)
    EGFR (Epidermal growth factor receptor)
    |
    EGFR C797S • EGFR L718Q