^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    EGFR H1975

    i
    Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
    Entrez ID:
    1956
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over3years
    First, #VEGF is highly expressed in #EGFR mutant cell lines (HCC827, H3255) and TKI therapy drops VEGF mRNA while in resistant setting (H1975 with T790M), erlotinib has no impact on high VEGF levels. In EGFRmt NSCLC, VEGF secretion is EGFR dependent. (@StephenVLiu)
    Preclinical
    |
    EGFR (Epidermal growth factor receptor)
    |
    EGFR mutation • EGFR T790M • EGFR expression • EGFR overexpression • EGFR H1975
    |
    erlotinib