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BIOMARKER:
EGFR expression
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
Dako EGFR pharmDx™ (1)
Dako EGFR pharmDx™ (1)
Associations
(46)
News
Trials
Search handles
@AndresFCardonaZ
@StephenVLiu
@ilyassahinMD
@pashtoonkasi
@tpjmd
Search handles
@AndresFCardonaZ
@StephenVLiu
@ilyassahinMD
@pashtoonkasi
@tpjmd
Filter by
Latest
11ms
A first-in-human study is assessing the safety, efficacy, and pharmacokinetics of #DK210 for patients with EGFR-expressing solid tumors. @AlexSpiraMDPhD @VCSpecialists Read more in @TargetedOnc: https://t.co/IhcjGLJ16S #MedTwitter #OncTwitter (@TheUSONetwork)
11 months ago
Clinical • PK/PD data
|
EGFR (Epidermal growth factor receptor)
|
EGFR expression
|
DK210
12ms
The first patient has been dosed with #DK210 in a first-in-human, phase 1 clinical trial for patients with EGFR-expressing advanced solid tumors. @AlexSpiraMDPhD @VCSpecialists https://t.co/y6mVGHn3bE (@TargetedOnc)
12 months ago
Clinical • Metastases
|
EGFR (Epidermal growth factor receptor)
|
EGFR expression
|
DK210
over1year
Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade. #Immunotherapy #cancer https://t.co/hSeNRN43ol (@ilyassahinMD)
over 1 year ago
Checkpoint inhibition • IO biomarker
|
EGFR (Epidermal growth factor receptor) • CD55 (CD55 Molecule) • CD59 (CD59 Molecule)
|
EGFR expression
almost2years
Hypothesis-generating: Addition of afatanib to patients c/ EGFR over-expressing met gastric cancer should be explored. Addition of IO to chemo (or in place of chemo) for periop Rx of resectable gastric cancer should be explored, esp among pts c/ MSI-H/dMMR/hPDL1CPS tumors. (@tpjmd)
almost 2 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • MSI (Microsatellite instability)
|
MSI-H/dMMR • EGFR expression • EGFR overexpression • MET overexpression • MET expression
over2years
EGFR DNA Methylation Correlates With EGFR Expression, Immune Cell Infiltration, and Overall Survival in Lung Adenocarcinoma https://t.co/cdm4HdcPEr (@AndresFCardonaZ)
over 2 years ago
Clinical • Epigenetic controller
|
EGFR (Epidermal growth factor receptor)
|
EGFR expression
over2years
Preclinical data on #HER3 in #EGFR+ NSCLC @CCR_AACR. EGFR TKI increased HER3 expression and enhanced activity of HER3-DXd (patritumab deruxtecan). Early clinical data already show HER3-DXd can overcome resistance. Role in 1L to prevent resistance? #LCSM https://t.co/FjITR5Qs6P (@StephenVLiu)
over 2 years ago
EGFR (Epidermal growth factor receptor) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
|
EGFR expression • ERBB3 expression
|
patritumab deruxtecan (U3-1402)
over2years
#PTTO2021 Great talk by Dr. @HelenaYu923 on #EGFR transformed #SCLC. Tend to lose EGFR protein expression. RB1 and TP53 predict transformation (though even when lost, SCLC transformation is a minority). Poor outcomes with IO. Can we prevent transformation with early intervention? (@StephenVLiu)
over 2 years ago
EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1)
|
EGFR expression • TP53 expression
over2years
Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling https://t.co/hOQBlqxAZf (@AndresFCardonaZ)
over 2 years ago
EGFR (Epidermal growth factor receptor) • PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1)
|
EGFR expression
almost3years
#ASCO21 In this cohort, 20 patients had tissue for IHC. Ten patients were IHC+ for EGFR/MET expression and RR to amivantamab/lazertinib was 90% with DOR 9.7m, CBR 100%, mPFS 12.5m. This is very impressive. #LCSM (@StephenVLiu)
almost 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • MET (MET proto-oncogene, receptor tyrosine kinase)
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EGFR expression • MET expression
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Rybrevant (amivantamab-vmjw) • Leclaza (lazertinib)
over3years
First, #VEGF is highly expressed in #EGFR mutant cell lines (HCC827, H3255) and TKI therapy drops VEGF mRNA while in resistant setting (H1975 with T790M), erlotinib has no impact on high VEGF levels. In EGFRmt NSCLC, VEGF secretion is EGFR dependent. (@StephenVLiu)
over 3 years ago
Preclinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR T790M • EGFR expression • EGFR overexpression • EGFR H1975
|
erlotinib
over3years
#ESMO20 HER3 is expressed in 80% of #EGFR mutant NSCLC hence this ADC approach. Patritumab is an ADC with HER3 Ab linked to a topoisomerase I payload. Here, data from escalation (n=12) and expansion (n=45) in EGFR+ NSCLC after TKI (expansion was post chemo as well). #LCSM (@StephenVLiu)
over 3 years ago
EGFR (Epidermal growth factor receptor) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
|
EGFR mutation • EGFR expression • ERBB3 expression • ERBB3 mutation
|
patritumab (U3-1287)
almost4years
2️⃣Post EGFR⛔️ as in this case 👆🏼. You have to recheck these patients. Check tumor again for HER2 expression. At baseline it’s ~<2%; often distal/rectal. Post EGFR⛔️ can go up ~upwards of 15-20%. #TargetedChat #CRCSM #colorectalcancerawarenessmonth (@pashtoonkasi)
almost 4 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2)
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HER-2 expression • EGFR expression
4years
#OncoAlert Exploration of the impact of #EGFR TKIs on the #TME @CCR_AACR. Analysis of 138 patients with EGFR+ #NSCLC who received a 1st gen EGFR TKI and had pre/post biopsies. Assayed changes in PD-L1 expression, TIL density and TME makeup. #LCSM https://t.co/7BG16yrrei (@StephenVLiu)
4 years ago
Clinical • PD(L)-1 Biomarker
|
EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1)
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PD-L1 expression • EGFR expression
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