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    BIOMARKER:

    DDX41 mutation

    i
    Other names: DDX41, DEAD-Box Helicase 41, ABS, DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41, Probable ATP-Dependent RNA Helicase DDX41, DEAD Box Protein Abstrakt Homolog, DEAD Box Protein 41, Abstrakt, MGC8828, DEAD-Box Protein Abstrakt, Putative RNA Helicase, MPLPF
    Entrez ID:
    51428
    11ms
    Interesting data on germline DDX41 mut MDS @BloodJournal #MDSsm #leusm Prognosis not influenced by Multihit TP53 or CUX1 (7q locus- common in Biallelic DDX41 mut MDS) mutations. Particularly sensitive to HMA (no data on LEN) 🧐 curiouser… (@drsangeetmd)
    TP53 (Tumor protein P53) • CUX1 (cut like homeobox 1) • DDX41 (DEAD-Box Helicase 41)
    |
    DDX41 mutation
    11ms
    This is great! I’ve had 2 almost identical patients with DDX41 mutated AML in the last month. At least 1 of them I suspect a germline mutation (@ClarkCutrer)
    Clinical
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    DDX41 (DEAD-Box Helicase 41)
    |
    DDX41 mutation
    1year
    Can you observe pts with high grade #MDS or #AML with mutated #DDX41? Check out our experience. ⁦@MayoCancerCare⁩ ⁦@BloodCancerJnl⁩ Observation and treatment in DDX41-mutated acute myeloid leukemia and myelodysplastic syndrome https://t.co/z6M4actvZS (@AlkaliDr)
    Clinical
    |
    DDX41 (DEAD-Box Helicase 41)
    |
    DDX41 mutation
    1year
    MDS with DDX41-mutation defines a unique subtype of myeloid neoplasm that is distinct from other myeloid neoplasms | ⁦@BloodJournal⁩ | #leusm https://t.co/SMbAVrLphH (@BldCancerDoc)
    DDX41 (DEAD-Box Helicase 41)
    |
    DDX41 mutation