^
    almost2years
    Malignant Neutrophilia! Netrophilia + BCR-ABL p210 = CML BCR-ABL p230 = CML Lots of neutrophils! Not chronic neutrophilic leukemia ( which has CSF3R utation) CSF3R mutation = CNL Nuetrophilia minimal dysplasia ASXL1, NRAS, SETBP1, SRSF2 and TET2 = Atypical CML Dysplasia (@AaronGoodman33)
    ABL1 (ABL proto-oncogene 1) • NRAS (Neuroblastoma RAS viral oncogene homolog) • BCR (BCR Activator Of RhoGEF And GTPase) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • SRSF2 (Serine and arginine rich splicing factor 2) • CSF3R (Colony Stimulating Factor 3 Receptor) • SETBP1 (SET Binding Protein 1)
    over2years
    Malignant Neutrophilia! @doctorpemm Chronic neutrophilic leukemia Neutrophilia no dysplasia CSF3R mut Rx = Ruxolitnib->allo aCML BCR-ABL - Neutrophilia+dysplasia STBP1/ASXL1 Rx = HMA->allo CML BCR-ABL+ (p230!) Rx = imatinib Myeloma with neutrophilia Paraneoplastic⬆️GCSF (@AaronGoodman33)
    ASXL1 (ASXL Transcriptional Regulator 1) • CSF3R (Colony Stimulating Factor 3 Receptor)
    |
    imatinib