TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • SRSF2 (Serine and arginine rich splicing factor 2) • RAS (Rat Sarcoma Virus)

TP53 mutation • DNMT3A mutation • TET2 mutation • SRSF2 mutation

1year

Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury. https://t.co/ulTvq2IAdD #Lysozymenephropathy #EMH #MPNglomerulopathy #ASXL1 #RAS| #CKD #CMML excellent collaboration @MPAlexanderMD Nate Gipe @MayoClinicSOM Nelson Leung! (@MrinalPatnaik)

1 year ago

Clinical

ASXL1 (ASXL Transcriptional Regulator 1)

1year

Have you ever wondered what is the real impact of #PHF6 mutations in myeloid diseases? Then take a look at our latest article 😬! #AML #MDS #CMML @AlmanzaLeukMD @GeorginaGener @garciamanero @MDAndersonNews https://t.co/twlj1ydAKe (@AlexBataller)

1 year ago

PHF6 (PHD Finger Protein 6)

PHF6 mutation

1year

#CMML patients in 20-30% of cases demonstrate prominent plasmacytoid dendritic cell nodules that are CD 123/303 positive. This is very uncommon in #MPN (@MrinalPatnaik)

1 year ago

Clinical

CD123 (Interleukin 3 Receptor Subunit Alpha)

1year

It is very uncommon to see thrombocytosis and meg clustering in #CMML Are the MPN drivers clearly negative? Can you request IHC for CD123/303, dual esterase stain and a PB monocyte repartitioning flow? Happy to help with logistics. (@MrinalPatnaik)

1 year ago

CD123 (Interleukin 3 Receptor Subunit Alpha)

1year

Frontline Tx of TP53 mutated AML & AML after previous HMA’s for MDS/CMML are two of the highest unmet needs w/o a true SOC. Clinical trials are imperative here 👇 (@LeukDocJZ)

1 year ago

Clinical

TP53 (Tumor protein P53)

TP53 mutation

1year

65 ECOG 1 with #CMML CBC-wbc13,Hb10.1,Plt 791, Monocyte-2.7 Kary-N FISH-N NGS- SETBP1-33%, ASXL1 16 % Feels fine Tx-Observation vs HMA Vs Hydrea vs Referal for allo? @MrinalPatnaik @Dr_AmerZeidan @NicoGagelmann @nihardesai7 Mayo Mol Model- Int risk1 (@BijoyTelivala)

1 year ago

Next-generation sequencing

ASXL1 (ASXL Transcriptional Regulator 1) • SETBP1 (SET Binding Protein 1)

hydroxyurea

over1year

1/23 is World #BPDCN Day. Many of us have come together nucleating around this one molecule, CD123, on the cell surface of BPDCN (and #AML, #CMML, #MDS, #ALL, others). Below from https://t.co/00EY6hVsyh (@lane_andy)

over 1 year ago

CD123 (Interleukin 3 Receptor Subunit Alpha)

over1year

Juvenile myelomonocytic leukemia; moving forward. https://t.co/ndtDKhKUmv #JMML #Ras #KMT2A @MayoCancerCare (@MrinalPatnaik)

over 1 year ago

KMT2A (Lysine Methyltransferase 2A)

over1year

@NicholasShortMD presents an update on triplet tx w/ aza/ven/gilt in newly dx FLT3-mutated AML or R/R AML or HR MDS/CMML -> aza d1-7, gilt 80-120 mg d1-28 (less myelosupp w/ 80 mg dose), ven 1-28 (hold early if <5% blasts d14) -> 27 newly dx and 20 R/R pts. #leusm #ASH22 1/2 (@MarkGeyerMD)

over 1 year ago

Clinical

FLT3 (Fms-related tyrosine kinase 3)

FLT3 mutation

Venclexta (venetoclax) • azacitidine

over1year

Proliferative CMML that is R/R or intolerant to HMA and/or Hydrea. While we don’t have mutational restrictions for enrollment we anticipate responses in #RAS pathway mutant #CMML #NRAS #KRAS #CBL #PTPN11 #NF1 (@MrinalPatnaik)

over 1 year ago

KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • NF1 (Neurofibromin 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11)

KRAS mutation • NRAS mutation • RAS mutation

hydroxyurea

over1year

Role of ASXL1 in Hematopoiesis and Myeloid Diseases [Sep 29, 2022] Gao et al. Experimental Hematology @ISEHSociety https://t.co/ZiU0fEAk6p #PrecisionMedicine #camoldx #HOXA #CMML HT @MrinalPatnaik (@mtmdphd)

over 1 year ago

ASXL1 (ASXL Transcriptional Regulator 1)

over1year

In #CMML pDC nodules are mostly mature, in pDC-AML range frm immature (CD34+,CD123 bright,CD303 dim/-) to mature (CD34-,CD123 bright,CD303+) By flow, MPDCP defined as ≥2% of non-erythroids in BM or🩸👇🏻by @drwenbin_xiao @rosslevinemd in @BloodJournal https://t.co/lCPIcyMATi (@sanamloghavi)

over 1 year ago

CD123 (Interleukin 3 Receptor Subunit Alpha) • CD34 (CD34 molecule)

over1year

Thanks for referencing our work. Interestingly, RUNX1 mut enriched in pDC-AML, ~60-80% but rare in pDC-CMML or BPDCN. (@drwenbin_xiao)

over 1 year ago

RUNX1 (RUNX Family Transcription Factor 1)

almost2years

A “rabbit head”on CD45/SS, left shift by decreased CD10 & CD13/CD16, monocytosis, aberrant expression of CD56 &/or CD23, and increased CD14/CD16 are CMML flow signatures. A good cytometrist will be 1st to tell you that monocytosis is CMML. (@Hemester1)

almost 2 years ago

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • NCAM1 (Neural cell adhesion molecule 1) • CD14 (CD14 Molecule) • MME (Membrane Metalloendopeptidase) • FCER2 (Fc Fragment Of IgE Receptor II)

NCAM1 expression

almost2years

Flow Cytometry to Diagnose CMML! CD14/CD16 -> monocytes divided into 3 categories: CD14+/CD16- = classical (M01) CD14low/CD16+ = intermediate (M02) CD14-/CD16+ = non-classical (M03) M01 subset >94% = CMML! Sensitivity = 90.6% Specificity = 95.1% https://t.co/4bLoiyYnrO (@AaronGoodman33)

almost 2 years ago

CD14 (CD14 Molecule)

almost2years

Genes: TP53multihi FLT3 and MLL. Ok! No words for TP53, we do know it always impacts (well always when its frequency is not exceptional, i.e.. CMML and TP53...). (@t_swiftr)

almost 2 years ago

TP53 (Tumor protein P53)

almost2years

#EHA22 #mdssm Wiseman: Cusatuzab (anti-CD70) under study in AML, but planned study in MDS/CMML withdrawn. (@hemedoc)

almost 2 years ago