CEBPA mutation

Does this trial change your practice? Not for me as we were already giving GO with IC only for CBF-AML and not for non-CBF favorable risk #AMLsm such as NPM1-mutated or double/bZip CEBPA patients (@Dr_AmerZeidan)

I respect your opinion. The reason I named these journals b/c Yamanka factors/iPSC 1st paper Cell 2006, LIC (now LSCs) John Dick 1st paper Nature Medicine 1997, Pabst 1st paper showing cebpa mutation causing AML Nature Genetics 2001 etc...used same primers to sequence cebpa... (@FarheenaAA)

With NRAS I would prefer SCT, also what type/terminal biallelic cebpa mutation may also help Issue would be selecting the donor, should rule out Cebpa in donor and pediatric AML I would prefer to R/O inherited predisposition also(unrelated),otherwise will have to search for MUD (@vishvdeepkhush)

AML with bi-allelic mutation of CEBPA is usually CD7+ :) (@g_vassiliki)

Both CEBPA mutant AML and AML with Inv(3) often have aberrant CD7 expression. The latter often presents with preserved or elevated platelets but unfortunately has a rather dismal prognosis (@TheDoctorIsVin)

CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome | Blood | American Society of Hematology! Wow!!!!! https://t.co/V8Nli1gMTb (@syed_abutalibmd)

CEBPA mutations in AML: site matters | Blood | American Society of Hematology. Very interesting! https://t.co/S93ZfnHqHU (@syed_abutalibmd)

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML https://t.co/hhXEF0crCG #AML (@BloodJournal)

where can I get more info on cebpa? Both of my kids got AML due to Cebpa mutation. This is a familial mutation. Wondering what progress has been made so far? (@Donor4Lillian)

In examples of familial AML/MDS, mutations in CEBPA, RUNX1, GATA2, DDX41....... are present decades before overt symptoms/disease arise @AshAlizadeh @JohnPLeonardMD with some carriers asymptomatic for a lifetime - should we be surprised at all? (@fitzgi02)