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BIOMARKER:
CDKN2A negative
i
Other names:
CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf, Cyclin-dependent kinase inhibitor 2A
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News alerts, weekly reports and conference planners
Entrez ID:
1029
Related biomarkers:
Expression
Mutation
CNA
Others
‹
›
Associations
(5)
News
Trials
Search handles
@VivekSubbiah
Search handles
@VivekSubbiah
Filter by
Latest
10ms
Very promising activity observed with BCA101 + pembro in p16 negative cps 1-19% 1st line R/M HNSCC. Exceptional presentation by @HeadNeckMD at #ASCO23 (@AhernandoCalvo)
10 months ago
CDKN2A negative
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
2years
Urothelial carcinoma, microcystic subtype. Almost becoming tubular morphology (described before). IHC GATA3 and KRT7. p63 positive, PAX8/CDX2/p16 negative. #gupath @Williamson_SR @LiangChengMD @GladellPaner @rovingatuscap (@AkgulMd)
2 years ago
KRT7 (Keratin-7) • CDX2 (Caudal Type Homeobox 2) • TP63 (Tumor protein 63) • GATA3 (GATA binding protein 3) • PAX8 (Paired box 8)
|
CDKN2A negative • PAX8 positive
2years
Genetic restoration of p16ink4A suppresses mesothelioma in preclinical models, underpinning the rationale for targeting CDK4 and CDK6 in p16ink4A-negative mesothelioma. We developed a multicentre, stratified, phase 2 trial to test this hypothesis 3/5 (@VivekSubbiah)
2 years ago
P2 data
|
CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6)
|
CDKN2A negative
2years
This study met its primary endpoint, showing promising clinical activity of abemaciclib in patients with p16ink4A-negative mesothelioma who were previously treated with chemotherapy, and warrants its further investigation in a randomised study as a targeted stratified therapy 5/5 (@VivekSubbiah)
2 years ago
Clinical
|
CDKN2A (Cyclin Dependent Kinase Inhibitor 2A)
|
CDKN2A negative
|
Verzenio (abemaciclib)
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