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    BIOMARKER:

    CDK12 mutation

    i
    Other names: CDK12, Cyclin Dependent Kinase 12, Cdc2-Related Kinase, Arginine/Serine-Rich, Cell Division Cycle 2-Related Protein Kinase 7, Cell Division Protein Kinase 12, CDC2-Related Protein Kinase 7, Cyclin-Dependent Kinase 12, CRKRS, CRK7, CDC2 Related Protein Kinase 7, HCDK12, CrkRS, CRKR
    Entrez ID:
    51755
    Related biomarkers:
    Mutation
    CNA
    Related tests:
    1year
    CHMP recommends naraparib/abi for 1st line CRPC with BRCA1/2 mutations only, based on MAGNITUDE, but this had a wider HRR biomarker panel (ATM, BRIP1, CDK12, CHEK2, FANCA, HDAC2, PALB2). Are these just passengers?⬆️ momentum for BRCA for PARPi in CRPC https://t.co/ZjbyXDxo27 (@tompowles1)
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PALB2 (Partner and localizer of BRCA2) • CDK12 (Cyclin dependent kinase 12) • BRCA (Breast cancer early onset) • CHEK2 (Checkpoint kinase 2) • FANCA (FA Complementation Group A) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • HDAC2 (Histone deacetylase 2)
    |
    BRCA2 mutation • BRCA1 mutation • CDK12 mutation • CHEK2 mutation • BRIP1 mutation • FANCA mutation
    over3years
    In case you missed it: a retrospective multicenter study to identify patients with advanced prostate cancer who harbored somatic loss-of-function CDK12 mutations from PCCTC investigators @EAntonarakis and Maha Hussain and colleagues: https://t.co/2pRObdMZuL (@ThePCCTC)
    Retrospective data
    |
    CDK12 (Cyclin dependent kinase 12)
    |
    CDK12 mutation