CDH1 mutation

Signet-Ring / Poorly Cohesive adenocarcinoma of pancreas, No CDH1 mutations in this highly aggressive pancreatic cancer variant (unlike gastric signet ring cell cancers). Great images. (@RZitwer)

I can give you just one point and it's on Hereditary Diffuse Gastric Cancer, because CDH1 mutation. The rest is just Ancestry-Based-TeReo-Speculative Medicine. (@MarshallButters)

Check out our poster on CDH1 mutated bladder cancer 👉217 tumors 👉65% plasmacytoid histology 👉Unique genomic landscape:🔼TMB, MSI, MTOR activation, 🔽FGFR3 GAs 👉Resistant to ICB #ASCO23 @FoundationATCG @MoffittNews @KyleRoseMD @SpiessPhilippe @PGrivasMDPhD @FDavaro @EPDavaro (@UrogerliMD)

CDH1-mutated #urothelialcarcinoma could define a distinct disease characterized by fewer responses to 1L IO monotherapy vs standard chemo @FoundationATCG @GTumors @SpiessPhilippe @PGrivasMDPhD @UrogerliMD @MyUniSR @urotoday @ASCO #GU23 (@AndreaNecchi)

Just to pause and reflect: Gastric signet ring cell CA in a 11 yo kid, negative for CDH1 mutation, no other known genetic syndromes....poor kid also has to deal with ADHD and autism spectrum disorder.. too unfortunate!! @GastricCancerFD @ASCO @cityofhope @DrRaviSalgia @USGIPS (@mannanrifat03)

Difficulty navigating a diagnosis of #CDH1 mutation? 👉Patient Resources for Hereditary Diffuse Gastric Cancer https://t.co/CxsnTiOwLV #HDGC @NoStomach4Cancr @StoCANcer @StomachCancer_ @GastricCancerFD @feedthecure (@JeremyLDavisMD)

Does germline #CDH1 mutation raise the risk of colon polyps or colon cancer? We addressed this question in a new publication: https://t.co/TVM4DA7P6u @MonicaPassiMD @NIDDKgov @NCIResearchCtr @NoStomach4Cancr #HDGC #StomachCancerAwareness (@JeremyLDavisMD)

Lobular #BreastCancer is molecularly different from IDC. #ctDNA mutations in CDH1, ERBB2, PTEN were associated with ILC. Similarly, CDH1 was co-mutated with PIK3CA, ERBB2 and ET resistance alterations in a cohort of ~7000 #MBC patients #bcsm #LiquidBiopsy https://t.co/Tx2fmuhug3 (@LGerratana)

Lobular #BreastCancer was associated with #ctDNA mutations in CDH1, ERBB2 and PTEN. Similarly, in an independent cohort of ~7000 #MBC patients, CDH1 was co-mutated with targetable (PIK3CA, ERBB2) and endocrine resistance alterations. #bcsm #LiquidBiopsy https://t.co/Tx2fmuhug3 (@LGerratana)

Presenting our work on CDH1 mutations and risk of colon cancer. @burkegastrodoc @LadyKatherineM1 @margaretmalley @jsommov @DavidLiskaMD @MargaretOMalley @AmCollegeGastro #ACG2022 (@Chatterjee_MD)

#TumorBoardTuesday I definitely like the germline genetic testing plan. I occasionally see a gastric cancer patient with a family history of lobular breast cancer and I wonder - CDH1 mutation? @HHampel1 (@MPishvaian)

Removal of the stomach is often necessary to prevent #stomachcancer due to #CDH1 gene mutation. Read how two patient’s stomachs were kept alive in a novel study led by @JeremyLDavisMD @NCICCR_Foregut @NIHClinicalCntr https://t.co/9VRAzi3srz #StomachCancerAwareness (@NCIResearchCtr)

Sasa Woodruff (@trowelandfork) speaks about her challenging decision to undergo a total gastrectomy after finding out she carries a germline CDH1 mutation. The signet ring cell gastric cancers in this setting can be focal & microscopic. This is what #pathologists are looking for: https://t.co/hpFanY1hlx (@Aiims1742)

Video 2 from MCC GI Onc Video Library! Robotic total gastrectomy for #CDH1 mutation and early gastric cancer by @jose_pimiento3 @DavidPointerMD @SocSurgOnc @NoStomach4Cancr @IkomaMD @JeremyLDavisMD @SeanP_Dineen @SyedAAhmad5 @JournalofGISurg https://t.co/phr3v1sg67 (@DenboJw)

Just out and a must read! A comprehensive review of CDH1 mutations and hereditary gastric cancer by Drs. Gamble @LaurenGambleMD and Davis @JeremyLDavisMD from .@NCICCR_SurgOnc .@NCI_SurgOncFel Congrats Lauren! https://t.co/XUkO1wx7S0 via @JAMASurgery part of @JAMANetwork (@TKhan_GS)

Removal of the stomach is often necessary to prevent #stomachcancer due to #CDH1 gene mutation. Read how two patient’s stomachs were kept alive in a novel study led by @JeremyLDavisMD @NCICCR_Foregut @NIHClinicalCntr https://t.co/9VRAzil3Q9 (@NCIResearchCtr)

TCGA analysis of early onset and traditional GC. Note the frequency of CDH 1 and TP53 mutations. Morphologic and molecular analysis of early‐onset gastric cancer https://t.co/3Px0AcSR41 @JournalCancer @uc_ccb @UCCOM_MedSci @agrothey (@SyedAAhmad5)