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BIOMARKER:
CCND1 amplification
i
Other names:
CCND1, BCL1, D11S287E, PRAD1, U21B31, Cyclin D1
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Entrez ID:
595
Related biomarkers:
Expression
Mutation
Others
‹
›
Associations
(10)
News
Trials
Search handles
@FaltasLab
@antgiorda
@neerajaiims
Search handles
@FaltasLab
@antgiorda
@neerajaiims
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Latest
11ms
Congrats Bishoy & team @FaltasLab, for unraveling intricate interactions between endogenous and Rx induced mutagenic mechanisms and ecDNA in the context of #bladdercancer evolution->CDK4/6 inhibitors like abemaciclib seems promising in UC with CCND1 ecDNA amplification… https://t.co/XQP9af3REc (@neerajaiims)
11 months ago
CCND1 (Cyclin D1)
|
CCND1 amplification
|
Verzenio (abemaciclib)
11ms
Importantly, we identified that 67% of CCND1 amplification events in UC tumors were due to ecDNA events. We confirmed that #bladdercancer harbors the highest proportion of circular ecDNA-based CCND1 amplification in thousands of TCGA/PCAWG human cancers (@FaltasLab)
11 months ago
CCND1 (Cyclin D1)
|
CCND1 amplification
12ms
No responses with Palbociclib in nonbreast tumors with a CCND1, 2, or 3 amplification in NCI-MATCH. These data do not support further investigation of single-agent palbo in tumors with CCND1, 2, or 3 amplification. Other CDKi under study in this setting https://t.co/HcumvQml68 (@antgiorda)
12 months ago
CCND1 (Cyclin D1)
|
CCND1 amplification
|
Ibrance (palbociclib)
12ms
Are tumors with amplification of CCND1, 2 or 3 sensitive to CDK4/6 inhibitor #Palbociclib? Clark et al test this hypothesis but their results do not support Palbociclib use in non-breast tumors containing a CCND1, 2 or 3 amplification. https://t.co/5HrLEiSamZ @AngieDemichele (@CCR_AACR)
12 months ago
CCND1 (Cyclin D1)
|
CCND1 amplification
|
Ibrance (palbociclib)
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