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BIOMARKER:
BTK mutation
i
Other names:
BTK, Bruton Tyrosine Kinase, Bruton Agammaglobulinemia Tyrosine Kinase, Tyrosine-Protein Kinase BTK, Bruton'S Tyrosine Kinase, B-Cell Progenitor Kinase, AGMX1, ATK, BPK, Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17), Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase, Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14), Truncated Bruton Agammaglobulinemia Tyrosine Kinase, Agammaglobulinaemia Tyrosine Kinase, Agammaglobulinemia Tyrosine Kinase, PSCTK1, IGHD3, IMD1, XLA, AT
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Entrez ID:
695
Related biomarkers:
Expression
Mutation
‹
BTK C481S (9)
BTK C481 (2)
BTK C481R (2)
BTK C481R + BTK L528W (1)
BTK C481S + BTK R665W + BTK L845F + BTK S707Y (1)
BTK C481S + PLCG2 D1140G (1)
BTK C481S + PLCG2 D1140N (1)
BTK C481S + PLCG2 L845F (1)
BTK C481Y (1)
BTK L528W + BTK C481 (1)
BTK R665W (1)
BTK T474I (1)
BTK C481S + MYD88 mutation (0)
BTK L845F (0)
BTK S707Y (0)
BTK C481S (9)
BTK C481 (2)
BTK C481R (2)
BTK C481R + BTK L528W (1)
BTK C481S + BTK R665W + BTK L845F + BTK S707Y (1)
BTK C481S + PLCG2 D1140G (1)
BTK C481S + PLCG2 D1140N (1)
BTK C481S + PLCG2 L845F (1)
BTK C481Y (1)
BTK L528W + BTK C481 (1)
BTK R665W (1)
BTK T474I (1)
BTK C481S + MYD88 mutation (0)
BTK L845F (0)
BTK S707Y (0)
›
Associations
(3)
News
Trials
Search handles
@dgermain21
@thomaseliotlew
@tobyeyre82
Search handles
@dgermain21
@thomaseliotlew
@tobyeyre82
Filter by
Latest
over1year
Brilliant work Abdel-Wahab #ASH22 #CLL Kinase dead (d) BTK mutations, like L528W, seen esp with PIRTO/ZANU dBTK restore BCR signalling by ^^ interaction with LYN, HCK, SYK others (scaffolding) PROTAC degrad of BTK active across muts, pt data too Will these muts guide sequencing? (@thomaseliotlew)
over 1 year ago
BTK (Bruton Tyrosine Kinase) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • SYK (Spleen tyrosine kinase)
|
BTK mutation
over2years
Pre-clinical data for #vecabrutinib in @BloodJournal Non-covalent BTKi inhibitory effect on C481S BTK mutants in vitro - ITK inhibitory activity (cf ibrutinib) - vecabrutinib + venetoclax synergstic But Sunesis cancelled phase II as lack of adequate efficacy in phase Ib in #CLL (@tobyeyre82)
over 2 years ago
P1 data • P2 data
|
BTK (Bruton Tyrosine Kinase)
|
BTK C481S • BTK mutation
|
Venclexta (venetoclax) • Imbruvica (ibrutinib) • vecabrutinib (SNS-062)
over3years
And lastly, one could model the probability that a mutation in DNMT3A is in CHIP clone (common) vs. T-cell lymphoma (highly recurrent), compared to BTK mutation in CHIP clone (rare/unreported) vs B-cell lymphoma (highly recurrent). Context is key. (@dgermain21)
over 3 years ago
DNMT3A (DNA methyltransferase 1) • BTK (Bruton Tyrosine Kinase)
|
DNMT3A mutation • BTK mutation
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