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BIOMARKER:
BTK C481S
i
Other names:
BTK, Bruton Tyrosine Kinase, Bruton Agammaglobulinemia Tyrosine Kinase, Tyrosine-Protein Kinase BTK, Bruton'S Tyrosine Kinase, B-Cell Progenitor Kinase, AGMX1, ATK, BPK, Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17), Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase, Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14), Truncated Bruton Agammaglobulinemia Tyrosine Kinase, Agammaglobulinaemia Tyrosine Kinase, Agammaglobulinemia Tyrosine Kinase, PSCTK1, IGHD3, IMD1, XLA, AT
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Entrez ID:
695
Related biomarkers:
Expression
Mutation
‹
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Associations
(9)
News
Trials
Search handles
@tobyeyre82
Search handles
@tobyeyre82
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Latest
over2years
Pre-clinical data for #vecabrutinib in @BloodJournal Non-covalent BTKi inhibitory effect on C481S BTK mutants in vitro - ITK inhibitory activity (cf ibrutinib) - vecabrutinib + venetoclax synergstic But Sunesis cancelled phase II as lack of adequate efficacy in phase Ib in #CLL (@tobyeyre82)
over 2 years ago
P1 data • P2 data
|
BTK (Bruton Tyrosine Kinase)
|
BTK C481S • BTK mutation
|
Venclexta (venetoclax) • Imbruvica (ibrutinib) • vecabrutinib (SNS-062)
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