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    BIOMARKER:

    BRIP1 mutation

    i
    Other names: BRCA1 Interacting Protein C-Terminal Helicase 1, BRCA1-Associated C-Terminal Helicase 1, BRCA1/BRCA2-Associated Helicase 1, ATP-Dependent RNA Helicase BRIP1, Fanconi Anemia Group J Protein, BACH1, FANCJ, BRCA1-Binding Helicase-Like Protein BACH1, BRCA1-Interacting Protein 1, Protein FACJ, BRCA1 Interacting Protein C-terminal Helicase 1
    Entrez ID:
    83990
    Related biomarkers:
    Expression
    Mutation
    Others
    Related tests:
    1year
    CHMP recommends naraparib/abi for 1st line CRPC with BRCA1/2 mutations only, based on MAGNITUDE, but this had a wider HRR biomarker panel (ATM, BRIP1, CDK12, CHEK2, FANCA, HDAC2, PALB2). Are these just passengers?⬆️ momentum for BRCA for PARPi in CRPC https://t.co/ZjbyXDxo27 (@tompowles1)
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PALB2 (Partner and localizer of BRCA2) • CDK12 (Cyclin dependent kinase 12) • BRCA (Breast cancer early onset) • CHEK2 (Checkpoint kinase 2) • FANCA (FA Complementation Group A) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • HDAC2 (Histone deacetylase 2)
    |
    BRCA2 mutation • BRCA1 mutation • CDK12 mutation • CHEK2 mutation • BRIP1 mutation • FANCA mutation
    over3years
    MHO: Need to look beyond the mere presence of mutations in this setting. As pointed out (☝️): Need to know if BRIP1 is mono / biallelic (w. #pancsm being a BRCA ass #cancer). If mono-allelic, high chance of being a mere bystander. Not sure about MEK inhibition in #pancsm (👇) (@BenWestphalen)
    BRCA Biomarker
    |
    BRCA (Breast cancer early onset) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1)
    |
    BRIP1 mutation