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    BIOMARKER:

    BRCA1 mutation + BRCA2 mutation

    i
    Other names: BRCA2, BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, Breast cancer 2, early onset, BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
    Entrez ID:
    672; 675
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Association of location of BRCA1 and BRCA2 mutations with benefit from olaparib and bevacizumab maintenance in high-grade ovarian cancer: Phase III PAOLA-1/ENGOT-ov25 trial subgroup exploratory analysis - ScienceDirect https://t.co/JyiMoQ8qGH (@0109Ayumi)
    Clinical
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    |
    BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
    |
    Avastin (bevacizumab) • Lynparza (olaparib)
    over2years
    Olaparib in early #breastcancer Excellent practical Q/A tips - for Germline BRCA1 and/or BRCA2 Mutation Carriers https://t.co/8OlrKzCsXo @JCOOP_ASCO @ASCO @OncoAlert (@jamecancerdoc)
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    |
    BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
    |
    Lynparza (olaparib)
    over2years
    @Priyabhard of @WeillCornellGS is an #SABCS21 Basic Science Scholar for "Obesity is associated with DNA damage in the breast epithelium of BRCA1 and BRCA2 mutation carriers: A role for estrogens & strategies for prevention," P2-06-03 Wednesday, Dec. 8, 5 p.m. #meetthescholars (@SABCSSanAntonio)
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    |
    BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
    over3years
    Interesting manuscript on >2800 #pancsm patients in @myESMO @ESMO_Open : 124 patients (4,2%) carried a mutation in BRCA1/2 or PALB2. Mut were associated w distinct mol profile potentially predictive for response to ICI. @weldeiry @agrothey @OncoAlert 🚨 https://t.co/dZXWP9JR5f (@BenWestphalen)
    Clinical • BRCA Biomarker
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PALB2 (Partner and localizer of BRCA2)
    |
    BRCA2 mutation • BRCA1 mutation • PALB2 mutation • BRCA1 mutation + BRCA2 mutation
    over3years
    Good news: #PARP inhibition is an effective treatment for patients with metastatic #BreastCancer and gPALB2 or sBRCA1/2 mutations @OncoAlert @ASCO_pubs @judygarber5 @DrEricWiner #bcsm #OncoAlert https://t.co/Z2uRxVXUbb (@AlexTihonoff)
    Clinical • BRCA Biomarker • PARP Biomarker
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    |
    BRCA2 mutation • BRCA1 mutation • PALB2 mutation • BRCA1 mutation + BRCA2 mutation