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BIOMARKER:
BRCA wild-type
i
Other names:
BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset, BRCA2, BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, Breast cancer 2, early onset
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News alerts, weekly reports and conference planners
Entrez ID:
672
;
675
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRCA2 mutation (200)
BRCA1 mutation (196)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA2 A902fs*2 (3)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA2 mutation + CHEK2 mutation (2)
BRCA2 mutation + TP53 mutation (2)
BRCA2 rearrangement (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
APC mutation + BRCA2 mutation (1)
BRCA2 1153insT (1)
BRCA2 5396insC (1)
BRCA2 I2315T (1)
BRCA2 L557* (1)
BRCA2 N255fs + D252fs (1)
BRCA2 Y1655* + TP53 mutation (1)
BRCA2 biallelic inactivation (1)
BRCA2 mutation + ATM mutation (1)
BRCA2 mutation + CDK12 mutation (1)
BRCA2 mutation + SPOP mutation (1)
BRCA2 mutation + TP53 D816Y (1)
CHEK2 mutation + ATM mutation + BRCA2 mutation (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
BRCA2 E260fs (0)
BRCA2 N255_R259delinsIK (0)
BRCA2 N255fs (0)
BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)
BRCA2 mutation (200)
BRCA1 mutation (196)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA2 A902fs*2 (3)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA2 mutation + CHEK2 mutation (2)
BRCA2 mutation + TP53 mutation (2)
BRCA2 rearrangement (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
APC mutation + BRCA2 mutation (1)
BRCA2 1153insT (1)
BRCA2 5396insC (1)
BRCA2 I2315T (1)
BRCA2 L557* (1)
BRCA2 N255fs + D252fs (1)
BRCA2 Y1655* + TP53 mutation (1)
BRCA2 biallelic inactivation (1)
BRCA2 mutation + ATM mutation (1)
BRCA2 mutation + CDK12 mutation (1)
BRCA2 mutation + SPOP mutation (1)
BRCA2 mutation + TP53 D816Y (1)
CHEK2 mutation + ATM mutation + BRCA2 mutation (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
BRCA2 E260fs (0)
BRCA2 N255_R259delinsIK (0)
BRCA2 N255fs (0)
BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)
›
Associations
(19)
News
Trials
Search handles
@ErikaHamilton9
@RenoHemonc
@benjiwal
Search handles
@ErikaHamilton9
@RenoHemonc
@benjiwal
Filter by
Latest
10ms
Second-line maintenance therapy with niraparib improved overall survival vs active surveillance in patients with recurrent BRCA wild-type ovarian cancer. @rcoledude #ovca #ASCO23 https://t.co/MNEYhPArVr (@OncLive)
10 months ago
Clinical
|
BRCA (Breast cancer early onset)
|
BRCA wild-type
|
Zejula (niraparib)
10ms
Second-line maintenance therapy with niraparib improved overall survival vs active surveillance in patients with recurrent BRCA wild-type ovarian cancer. @rcoledude #ovca #ASCO23 https://t.co/Ggf2NEur0I (@OncLive)
10 months ago
Clinical
|
BRCA (Breast cancer early onset)
|
BRCA wild-type
|
Zejula (niraparib)
1year
True mCRPC pts are dwindling as most of them are started on ADT + NHT. For second line progression - BRCA/ CHEK2 m-> switch to single agent PARPi vs add it on top of NHT? For BRCA WT -Add PARPi and continue NHT? (@RenoHemonc)
1 year ago
Clinical
|
BRCA (Breast cancer early onset) • CHEK2 (Checkpoint kinase 2)
|
BRCA wild-type
1year
Question for the experts: 54 yo woman with right TNBC pT2N1M0, BRCA wt. Met her after surgery 😒. @hoperugo @darioT_ @PTarantinoMD @Dr_RShatsky @fnacevedo @CesarGSanchezR @SuyogCancer (@benjiwal)
1 year ago
Surgery
|
BRCA (Breast cancer early onset)
|
BRCA wild-type
over1year
I do think in the TNBC, wild type BRCA space that have high TMB the use of immunotherapy has been disappointing. This is the space that clearly needs to most amount of work. (@DrARS77)
over 1 year ago
TMB (Tumor Mutational Burden) • BRCA (Breast cancer early onset)
|
TMB-H • BRCA wild-type
over1year
A phase II trial shows promising results with the PARP ihibitor talazoparib in patients with wild-type BRCA1/2 advanced #breastcancer https://t.co/J8nPPVWJ4b #fondazionebonadonna #oncology #cancerreseach @BianchiniGP @mauricallari @CarmenCriscit (@FondazioneBona1)
over 1 year ago
Clinical
|
BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PARP1 (Poly(ADP-Ribose) Polymerase 1)
|
BRCA wild-type
|
Talzenna (talazoparib)
over1year
12/18 #TumorBoardTuesday #BCSM 🌟We are now in the realm of ADCs! Because our 👩🏾 was: 🧬gBRCA wild type 🔬Her2 1+ 🔥#ProTip 👉🏽This is when I would send off genomic profiling if I hadn’t already. Then I have it. If I have a 🦄, I am ready to consider those agents in 3rd Line (@LauraSalamaMD)
over 1 year ago
HER-2 (Human epidermal growth factor receptor 2)
|
BRCA wild-type
over1year
@seemagulia1 @TataMemorial publish the only IPD metaanalysis PARP-inhibitors first-line ovarian cancer! Highly impactful results, clear benefit BRCA-mut or HRD-pos pts, but NOT in BRCA-wt/HRD-neg pts! @jamecancerdoc @AnaOaknin @myESMO @ASCOPost @sujithonco https://t.co/eXGgl26gAt (@ACTREC_TMC)
over 1 year ago
Retrospective data
|
BRCA (Breast cancer early onset)
|
BRCA wild-type
almost2years
Excited to see if BET + PARP can sensitize BRCA wt tumors to talazoparib. Looking at pts who have seen saci as well. #ASCO22 #bcsm (@ErikaHamilton9)
almost 2 years ago
Clinical
|
BRCA (Breast cancer early onset) • PARP1 (Poly(ADP-Ribose) Polymerase 1)
|
BRCA wild-type
|
Talzenna (talazoparib)
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