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BIOMARKER:
BRAF mutation
i
Other names:
BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
Oncomine™ Dx Target Test (10)
Idylla™ ctNRAS-BRAF Mutation Test
Lung Cancer 8-Gene Kit
Oncomine™ Dx Target Test (10)
Idylla™ ctNRAS-BRAF Mutation Test
Lung Cancer 8-Gene Kit
Associations
(129)
News
Trials
Search handles
@ADesaiMD
@APassaroMD
@AaronGoodman33
@Abdallah81MD
@AndresC27622123
@AnkitmanglaMD
@ArndtVogel
@AshaKarippot
@BenWestphalen
@BijoyTelivala
@CathyEngMD
@CharuAggarwalMD
@DrBetofMDPhD
@DrBonillaOnc
@DrDrAprilRose
@DrJNaidoo
@DrOlaLandgren
@DrRiyazShah
@DrSanjayPopat
@DrSteveMartin
@DrVijayPatil11
@DrYukselUrun
@Dr_Ivanoncologo
@Dr_R_Kurzrock
@DrewMoghanaki
@EvanHallMD
@FilipJankuMD
@FunchainMD
@G_LipositsMD
@IbrahimSahinMD1
@JulienMazieres
@Kristel_GT
@KristenCiombor
@LeciaSequist
@Melanoma_doctor
@Mi_onc
@MichalisLiontos
@Myeloma_Doc
@NReguart
@NimaSharifiMD
@OlofssonBagge
@OmidHamidMD
@OncoloJo
@PAscierto
@PatrickCMa1
@RenoHemonc
@RielyMD
@RonenStoff
@SalemGIOncDoc
@StephenVLiu
@SyedMAhmedMDPhD
@Tony_Calles
@UmutDisel
@VanMorrisMD
@VivekSubbiah
@ad1600
@ahmadalhader
@beatalleukemia
@boutrosand
@cancerassassin1
@cczielinski
@davidhenrymd
@dipeshuprety4
@doctorC369
@dplanchard
@jasonlukemd
@malkadav
@mtmdphd
@navstruck
@neerajaiims
@ninashah33
@pashtoonkasi
@pawel_sobczuk
@rajshekharucms
@rbryanbell
@rschilsky
@ryanhuey
@smbenlazar
@weldeiry
Search handles
@ADesaiMD
@APassaroMD
@AaronGoodman33
@Abdallah81MD
@AndresC27622123
@AnkitmanglaMD
@ArndtVogel
@AshaKarippot
@BenWestphalen
@BijoyTelivala
@CathyEngMD
@CharuAggarwalMD
@DrBetofMDPhD
@DrBonillaOnc
@DrDrAprilRose
@DrJNaidoo
@DrOlaLandgren
@DrRiyazShah
@DrSanjayPopat
@DrSteveMartin
@DrVijayPatil11
@DrYukselUrun
@Dr_Ivanoncologo
@Dr_R_Kurzrock
@DrewMoghanaki
@EvanHallMD
@FilipJankuMD
@FunchainMD
@G_LipositsMD
@IbrahimSahinMD1
@JulienMazieres
@Kristel_GT
@KristenCiombor
@LeciaSequist
@Melanoma_doctor
@Mi_onc
@MichalisLiontos
@Myeloma_Doc
@NReguart
@NimaSharifiMD
@OlofssonBagge
@OmidHamidMD
@OncoloJo
@PAscierto
@PatrickCMa1
@RenoHemonc
@RielyMD
@RonenStoff
@SalemGIOncDoc
@StephenVLiu
@SyedMAhmedMDPhD
@Tony_Calles
@UmutDisel
@VanMorrisMD
@VivekSubbiah
@ad1600
@ahmadalhader
@beatalleukemia
@boutrosand
@cancerassassin1
@cczielinski
@davidhenrymd
@dipeshuprety4
@doctorC369
@dplanchard
@jasonlukemd
@malkadav
@mtmdphd
@navstruck
@neerajaiims
@ninashah33
@pashtoonkasi
@pawel_sobczuk
@rajshekharucms
@rbryanbell
@rschilsky
@ryanhuey
@smbenlazar
@weldeiry
Filter by
Latest
9ms
Nice shoutout to Dr @RonaYaeger trial Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer NCT05710406 public post w/ more info https://t.co/hbemZq4P6a #gdugi2023 (@fireflyann)
9 months ago
Surgery
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
Researchers are studying several alterations in pancreatic cancer, among them the BRAF mutation. One type of BRAF mutation may provide a target for treatment in pancreatic cancer patients, explains Dr. Michael Pishvaian @MPishvaian. https://t.co/jSMKge2aYR (@letswinpc)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
Hussein A. Tawbi, MD, PhD, and Allison Betof Warner, MD, PhD, discuss treatments for a patient with BRAF mutation–negative #melanoma. #melsm | @MDAndersonNews @StanfordCancer @DrBetofMDPhD https://t.co/iMqVhUSeET (@TargetedOnc)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
Researchers are studying several alterations in pancreatic cancer, among them the BRAF mutation. One type of BRAF mutation may provide a target for treatment in pancreatic cancer patients, explains Dr. Michael Pishvaian @MPishvaian. https://t.co/jSMKge2aYR #TumorBoardTuesday (@letswinpc)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
The @lustgartenfdn recently highlighted #BCCPC collaborator @MPishvaian's work leading a study targeting a BRAF mutation in patients with #PancreaticCancer at @JohnsHopkins Great work Dr. Pishvaian! https://t.co/L9ojMLrRjh (@OHSUpancreatic)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
Researchers are studying several alterations in pancreatic cancer, among them the BRAF mutation. One type of BRAF mutation may provide a target for treatment in pancreatic cancer patients, explains Dr. Michael Pishvaian (@MPishvaian). https://t.co/jSMKge2aYR (@letswinpc)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
🗣️:🇺🇲/👥: 👨⚕️🩸🦀 🤔 Peripheral flow cytometry for a possibility of firstly hairy cell leukemia and than marginal zone lymphoma. Bone marrow Asp&biopsy for BRAF mutation, and further differantiate possible causes. If one of them watch & wait might be a rational solution. (@Dr_MSU)
9 months ago
Biopsy
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
#FeatureFriday Today on #FeatureFriday, we are featuring a tweet by Dr. Vivek Subbiah [@VivekSubbiah]on a recent discovery that was made after a decade-long investigation into the relationship between Papillary Craniopharyngiomas and the BRAF mutation. #MedTwitter (@4baseCare)
10 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
Excellent presentation from @Antonio_arc95 discussing BRAF mutated metastatic melanoma in @SMEOMX resident session with @MKWongMDPhD . Learning valuable lessons from Dr. Wong and great cases with fellow residents from @incanMX and other institutions @incmnszmx @cmn20noviembre (@javiercboj)
10 months ago
Clinical • Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
Novel Combination Strategies in BRAF-Mutant Metastatic Colorectal Cancer: @marshalj23, @CathyEngMD, @GIcancerDoc, @aparna1024, and Stacey A. Cohen, MD, discuss. https://t.co/MtWjp9rG9r via @onclive (@RueschCenter)
10 months ago
Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
Today in Mexico City we launched the combination of encorafenib and binimetinib approved for adult patients with inoperable or metastatic melanoma positive at BRAF V600 mutation – @PAscierto #cancer #binimetinib #encorafenib #vemurafenib #oncodaily https://t.co/cdug6hYNaV (@oncodaily)
10 months ago
Clinical • Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
|
Zelboraf (vemurafenib) • Mektovi (binimetinib) • Braftovi (encorafenib)
10ms
Congratulations to our newly graduated fellow Dr. Albert Han on winning 🥇 prize at the @ahnsinfo poster competition examining expression differences in dedifferentiated BRAF-mutated papillary #thyroidcancer Awesome work! @MDAndersonNews (@JenniferWangMD)
10 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
Precision oncology for BRAF-mutant cancers with BRAF and MEK inhibitors: from melanoma to tissue-agnostic therapy @myESMO @ESMO_Open https://t.co/OV3yNXZnho (@VivekSubbiah)
10 months ago
Pan tumor
|
BRAF mutation
10ms
Excellent talk on BRAF mutated #mCRC given by Prof. @erikamartin3lli at #WCGIC2023. (@G_LipositsMD)
10 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
WATCH: @AlexSpiraMDPhD shares new dose escalation data from the first-in-human Phase 1 KIN-2787 study of the pan-RAF inhibitor exarafenib in patients with BRAF-altered solid tumors or NRAS-mutant melanoma. #melsm #Oncology https://t.co/5PNRZzBpRn (@OncLive)
10 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • NRAS mutation
|
exarafenib (KIN-2787)
10ms
BRAF mutation Seen in melanoma (40-60%) papillary thyroid carcinoma (45%), colonic adenocarcinoma (10-15%), hairy cell leukemia (~100%) lung adenocarcinoma, epithelioid glioblastoma, and hematologic malignancies, including hairy cell leukemia, LCH, ECD (@Sthanu5)
10 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
10ms
🚨 Featured in Best of #JCO #ASCO23 edition: Combination Dabrafenib and Trametinib vs Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant #Melanoma: The DREAMseq Trial—ECOG-ACRIN EA6134 Listen to the podcast: https://t.co/NzCxcbjBSy @jmkirkwood #melsm (@JCO_ASCO)
10 months ago
Clinical • Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
|
Opdivo (nivolumab) • Mekinist (trametinib) • Yervoy (ipilimumab) • Tafinlar (dabrafenib)
10ms
New @ALLIANCE_org A022004 trial led by .@RonaYaeger @MSKCancerCenter compares treatment w/encorafenib & cetuximab to usual care to reduce chance of cancer recurrence after standard surgery & chemotherapy in pts w/BRAF-mutated stage IIB-III #coloncancer: https://t.co/F1Oxrw98ah (@ALLIANCE_org)
10 months ago
Clinical • Surgery
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
|
Erbitux (cetuximab) • Braftovi (encorafenib)
11ms
This was helpful, particularly the cell + blood cancer explanation. Our child must be a unicorn, because she's BRAF neg and cobi didn't work... Luckily a CSF1R mutation was found, and it turned out to be targetable. Complete response to pexidartinib. (@onecolleen)
11 months ago
Clinical
|
BRAF (B-raf proto-oncogene) • CSF1R (Colony stimulating factor 1 receptor)
|
BRAF mutation
|
Turalio (pexidartinib)
11ms
WATCH: @AlexSpiraMDPhD shares new dose escalation data from the first-in-human Phase 1 KIN-2787 study of the pan-RAF inhibitor exarafenib in patients with BRAF-altered solid tumors or NRAS-mutant melanoma. #melsm #Oncology https://t.co/CICBP59rzb (@OncLive)
11 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • NRAS mutation
|
exarafenib (KIN-2787)
11ms
Dr Zeynep Eroglu @MoffittNews presents study of dab/tram +/- Navitoclax in BRAF mutated #melanoma. Interesting biological rationale. Good use of ETCTN mechanism to explore combo. Some unique stats (not designed to directly compare cohorts) given small N. #ASCO23 1/ (@EvanHallMD)
11 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
|
navitoclax (ABT 263)
11ms
Not only that, it is never BRAF mutated, AND, it does not respond to immune checkpoint inhibitors. Everyone who has a uveal melanoma with metastases should participate in a clinical trial. (@davideyoungmd)
11 months ago
Clinical • Checkpoint inhibition • IO biomarker
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
11ms
BRAF mutations and fusions in a real-world cohort of non-small cell lung cancer patients [Sep 12, 2022] Niu et al. #ESMO22 Abstract 1107P https://t.co/l8uUlYKK6P #PrecisionMedicine #lcsm @Bannermdandersn @TempusLabs (@mtmdphd)
11 months ago
Clinical • Real-world evidence • Real-world
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
11ms
BRAF mutations and fusions in a real-world cohort of non-small cell lung cancer patients [Sep 12, 2022] Niu et al. #ESMO22 Abstract 1107P https://t.co/l8uUlYKK6P #PrecisionMedicine #lcsm @Bannermdandersn @TempusLabs (@mtmdphd)
11 months ago
Clinical • Real-world evidence • Real-world
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
11ms
BRAF mutations and fusions in a real-world cohort of non-small cell lung cancer patients [Sep 12, 2022] Niu et al. #ESMO22 Abstract 1107P https://t.co/l8uUlYLhWn #PrecisionMedicine #lcsm @Bannermdandersn @TempusLabs (@mtmdphd)
11 months ago
Clinical • Real-world evidence • Real-world
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
11ms
WATCH: @AlexSpiraMDPhD shares new dose escalation data from the first-in-human Phase 1 KIN-2787 study of the pan-RAF inhibitor exarafenib in patients with BRAF-altered solid tumors or NRAS-mutant melanoma. #melsm #Oncology https://t.co/n1jCKm0JEJ (@OncLive)
11 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • NRAS mutation
|
exarafenib (KIN-2787)
11ms
The @myESMO preceptorship on colorectal cancer is going on. @grikamartinelli is now covering treatment for BRAF mutant and HER2 amplified tumors (@AndresC27622123)
11 months ago
HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene)
|
BRAF mutation • HER-2 amplification
11ms
🎥@rutkowskip1972 shares promising results on vemurafenib + cobimetinib for BRAF-mutated melanoma. The study shows extended OS and PFS compared to vemurafenib alone: 👉 https://t.co/168Ujoli2Z 👈 #MelSM #ESMOSarcomaandrarecancers23 @myESMO (@VJOncology)
11 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
|
Zelboraf (vemurafenib) • Cotellic (cobimetinib)
11ms
The debate is on for the management of BRAF-mutated ATC at the #ITOG meeting with @DrMCabanillas presenting our @MDAndersonNews data! Excited to see what trials this international collaborative will develop for aggressive #thyroidcancer (@DrAManiakas)
11 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
12ms
Molecular Biology & Treatment of Malignant Melanoma w/ BRAF V600 Mutations [Feb 28, 2014] @mullane_michael @JPCRR https://t.co/bf8HSIZxV7 #melsm #PrecisionMedicine (@mtmdphd)
12 months ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
12ms
Lifirafenib plus mirdametinib produced a tolerable safety profile and antitumor activity in patients with BRAF- or KRAS-mutant advanced or refractory solid tumors. @bensolomon1 @PeterMacCC #oncology #AACR23 https://t.co/qWYDxlVeWv (@OncLive)
12 months ago
Clinical • Metastases
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
KRAS mutation • BRAF mutation
|
mirdametinib (PD-0325901) • lifirafenib (BGB-283)
1year
Lifirafenib plus mirdametinib produced a tolerable safety profile and antitumor activity in patients with BRAF- or KRAS-mutant advanced or refractory solid tumors. @bensolomon1 @PeterMacCC #oncology #AACR23 https://t.co/tVk091WZsM (@OncLive)
1 year ago
Clinical • Metastases
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
KRAS mutation • BRAF mutation
|
mirdametinib (PD-0325901) • lifirafenib (BGB-283)
1year
✅ out JCO After Hours Podcast🎙️ w/ @ShannonWestin 🗣️ We discuss how Dr. Atkins’ DREAMSeq #ClinicalTrial helped define standard of care treatment in metastatic #BRAF mutant #melanoma w/ @ad1600 @DrGarySchwartz #melsm #ImmunoOnc (@JCO_ASCO)
1 year ago
Clinical • IO biomarker • Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
1year
BGB-3245 Demonstrates Efficacy in Solid Tumors With a Mutation in the MAPK Pathway - mostly BRAF https://t.co/AyidGZwZfm via @targetedonc (@DrBonillaOnc)
1 year ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
|
brimarefenib (BGB-3245)
1year
Happening soon at #AACR23: Reinhard Dummer takes the stage to report on KEYMAKER-U02 substudy 02C for stage IIIB-D melanoma. Take a look at phase 3 (COMBI -i) research from @HTawbi_MD et al on the potential in biomarkers in BRAF V600-mutant melanoma: https://t.co/MRLbZ635OE #JITC (@jitcancer)
1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
1year
Fantastic work by you & the study team. Will be interesting to use this in BRAF mutated AML (@beatalleukemia)
1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
1year
Congratulations Andy Futreal @MDAndersonNews for your induction as a Fellow of the @AACR Academy for seminal contributions to genomics. My patients benefit each day from your groundbreaking work discovering BRAF mutations in #melanoma and cloning BRCA1 and BRCA2. (@mcquadeMDLAc)
1 year ago
Clinical
|
BRAF (B-raf proto-oncogene) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
|
BRCA1 mutation • BRAF mutation
1year
This all BRAF targeting in multiple tumors started here 👉Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations | NEJM 9/10 @NEJM https://t.co/2HuCJEjfxR (@VivekSubbiah)
1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
|
Zelboraf (vemurafenib)
1year
First win for #precisionmedicine in rare cancer patients from the ROAR trial 3/10👉 Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600–Mutant Anaplastic Thyroid Cancer @JCO_ASCO @ASCO lead to FDA approval in this deadly cancer #AACR23… https://t.co/lP5WSL0nDc (@VivekSubbiah)
1 year ago
Clinical • FDA event • Metastases
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
|
Mekinist (trametinib) • Tafinlar (dabrafenib)
1year
Update on BRaf mutated NSCLC by @dplanchard #ELCC23 @OncoAlert (@JulienMazieres)
1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
1year
Nice review BRAF mutations in NSCLC #LCSM by @dplanchard #ELCC23 @myESMO (@NReguart)
1 year ago
Review
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
1year
#ELCC23 #LCSM @dplanchard discussing new advances in BRAF and METex14 mutations in #lungcancer A talk not to be missed @myESMO (@APassaroMD)
1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF mutation
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