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BIOMARKER:
BRAF K601E
i
Other names:
BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
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Associations
(7)
News
Trials
Search handles
@StephenVLiu
Search handles
@StephenVLiu
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Latest
1year
Unique spectrum of BRAF alts in prostate cancer! 👉3% BRAF activated, mostly rearrangements and K601E. 👉Diverse BRAF fusions detected both in tissue DNA (F1CDx) and liquid ctDNA (F1LCDx). Love the teamwork here!🙌 @neerajaiims @montypal @EAntonarakis @HTukachinsky ()
1 year ago
Circulating tumor DNA
|
BRAF (B-raf proto-oncogene)
|
BRAF fusion • BRAF K601E • BRAF K601
|
FoundationOne® CDx • FoundationOne® Liquid CDx
over3years
#OncoAlert Case in #JCOPO @ASCO_pubs of #BRAF K601E NSCLC. No response to chemo/IO or 2L docetaxel but rapid response to trametinib. Unfortunately, fairly transient (4m). Need better options, more trials for BRAF non-V600E drivers. #LCSM https://t.co/HrAnmGpChI (@StephenVLiu)
over 3 years ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF V600E • BRAF K601E • BRAF K601
|
Mekinist (trametinib) • docetaxel
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