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BIOMARKER:
BCL2 expression
i
Other names:
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2
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Entrez ID:
596
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
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Associations
(9)
News
Trials
Search handles
@AaronGoodman33
@DocMCotant
@Fer_martinmoro
@Rfonsi1
@graham74GC
@hemedoc
@kevinpunie
@michaelwangmd
@mtmdphd
Search handles
@AaronGoodman33
@DocMCotant
@Fer_martinmoro
@Rfonsi1
@graham74GC
@hemedoc
@kevinpunie
@michaelwangmd
@mtmdphd
Filter by
Latest
10ms
Hot off the press, our paper on interactions between COO and MYC/BCL2 expression in patients with relapsed LBCL undergoing ASCT. Thankful to my mentors at @MDAndersonNews Dr. Issa Khouri @Transplant_Doc @RichardChamplin and others #bmtsm #lymphoma #lymsm https://t.co/zoqRFsEd3G (@Taha_CancerDoc)
10 months ago
Clinical • IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
1year
Hey @myelomaMD ! Greetings from Brazil! Does BCL-2 expression on IHQ correlates with t(11;14) in MM? Is it able to predict response to venetoclax based therapy? Thank you! (@drvillefort)
1 year ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression
|
Venclexta (venetoclax)
over1year
#ASH22 #leusm Renders: GPR56 expression helps identify LSC. Mcl-1 expressed in differentiating cells while BCL2 more exclusively expressed in LSC of Ven responders, and thus BCL2:MCL-1 (assessed by MACS-Score) in LSC may be a biomarker to predict response. (@hemedoc)
over 1 year ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • MCL1 (Myeloid cell leukemia 1) • ADGRG1 (Adhesion G Protein-Coupled Receptor G1)
|
BCL2 expression • MCL1 expression
over1year
Double expression of MYC/BCL2 in PCNSL is related with worse PFS (not OS), less relevant if MATRIx + auto-SCT as frontline #lymphoma #ASH22 (@Fer_martinmoro)
over 1 year ago
IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MYC expression • MYC expression + BCL2 expression
over1year
Multicentre UK study showing double Myc / Bcl2 expressor primary CNS lymphoma associated with worse PFS (trend to OS) even in MATRix treated patients. Congrats to @Jessica_Okosun and her team. #ASH22 #lymsm (@graham74GC)
over 1 year ago
Clinical
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MYC expression
over1year
Oncology Board Review A 65 year old with HTN is diagnosed with stage IV (marrow involvement) DLBCL, double expresser (MYC+, BCL2+). IPI = 3. ECOG = 1. What's the most apprioeate treatment regimen? (ASCT = autologous stem cell transplantation) (@AaronGoodman33)
over 1 year ago
Review
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MYC expression
over1year
#DLBCL News: @gilles_salles, MD from @MSKCancerCenter discusses #MYC and #BCL2 Expression Impact Outcomes Post #FrontlineTreatment With #PV in DLBCL || For more of the top and trending #DLBCL videos visit: https://t.co/QCpxfDsNKd #medtwitter #hematology #research #onctwitter (@AggregoOncology)
over 1 year ago
IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MYC expression
almost2years
In this study by Quentmeier from Germany, anaplastic large cell lymphoma & primary effusion lymphoma, stood out by high expression of MCL1 & low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in cell lines in both lymphomas. https://t.co/AQ0NOdIgVz (@michaelwangmd)
almost 2 years ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MCL1 expression
|
AZD5991
over2years
#ASH21 #leusm Diaz-Flores: poor responders express high BCL2 as well as other antiapoptosis mediators including BCL-XL and MCL-1 (which raises concern whether Venetoclax will be able to entirely overcome Ino resistance in this population) (@hemedoc)
over 2 years ago
BCL2 (B-cell CLL/lymphoma 2) • MCL1 (Myeloid cell leukemia 1) • BCL2L1 (BCL2-like 1)
|
BCL2 expression
|
Venclexta (venetoclax)
over2years
#ASH21 #leusm Diaz-Flores: CD22 low / BCL2 high expression associated with poor response to Inotuzumab. This study used samples from COG AALL1621, age 1-21 (@hemedoc)
over 2 years ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CD22 (CD22 Molecule)
|
BCL2 overexpression • BCL2 expression
|
Besponsa (inotuzumab ozogamicin)
over2years
@myelomaMD presents final PH3 BELLINI data of venetoclax-Velcade/dex vs placebo-Vd in relapsed refractory #myeloma . Data supports further development with a biomarker-driven approach in t(11;14) and high BCL2 expressors. #ASH21 (@theMMRF)
over 2 years ago
Clinical • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression
|
Venclexta (venetoclax) • bortezomib
over2years
Vd +/- Venetoclax in patients with relapsed or refractory multiple myeloma (RRMM) (BELLINI): a Ph3 DB-RCT [Oct 29, 2020] @myelomaMD et al. @TheLancetOncol https://t.co/e983VJhIjV #NCT02755597 #mmsm #PrecisionMedicine Fig 3 PFS in (A) t(11;14) & (B) high BCL2 gene expression (@mtmdphd)
over 2 years ago
Clinical • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression
|
Venclexta (venetoclax)
over2years
Multiple myeloma with t(11;14)‐associated immature phenotype has lower CD38 expression and higher BCL2 dependence. Patients with t(11;14) have: - Lower CD38 - Lower CD138 - Higher PAX5 & CD79A - Higher BCL2/BCL2L1 ratio #mmsm https://t.co/dBc3Cco9ca (@Rfonsi1)
over 2 years ago
Clinical • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CD38 (CD38 Molecule) • BCL2L1 (BCL2-like 1) • PAX5 (Paired Box 5) • SDC1 (Syndecan 1)
|
CD38 expression • BCL2 expression
over2years
@AaronGoodman33 48yo lady w EGD showing gastric ulcer but incidental duodenal mucosal nodule bx follicular NHL of duodenal type; expressed CD20, coexpress CD10, BCL-2. Ki-67 was pos at less than 5%. CT CAP negative; bone marrow bx neg. Do you/followers think needs treatment? (@DocMCotant)
over 2 years ago
BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • MME (Membrane Metalloendopeptidase)
|
BCL2 expression • CD20 expression
over2years
Lymphoma Poll 70 year old with stage IV DLBCL. Expresses MYC and BCL2. Not double hit. Involvement of numerous extra-nodal sites including kidneys. LDH is elevated. Renal function normal. ECOG 2. Do you recommend CNS prophylaxis? @WomenInLymphoma (@AaronGoodman33)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MYC expression
almost3years
#ASCO21 #VERONICA fulvestrant +/- #venetoclax in 2/3L advanced ER+/HER2- #breastcancer 🔹similar CBR between arms (11.8 vs 13.7 mo) 🔹mPFS 2.7 vs 1.9 mo 🔹🚫predictive value of bcl-2 expression 🔹📈G3-4 AEs with combination Rx @OncoAlert #GeoffreyLindeman @ABhealer108 (@kevinpunie)
almost 3 years ago
IO biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2)
|
HER-2 negative • BCL2 expression
|
Venclexta (venetoclax)
over3years
I have just learned some myeloma cells have high BCL2 expression and BCL2 promotes survival of plasma cells. (@kitagawa_yukiko)
over 3 years ago
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression
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