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DRUG:
ficerafusp alfa (BCA101)
i
Other names:
BCA101, FmAb2, BCA 101, BCA-101
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Associations
(3)
News
Trials
Company:
Biocon
Drug class:
EGFR inhibitor, TGFβ inhibitor
Related drugs:
‹
cetuximab (347)
osimertinib (301)
erlotinib (235)
afatinib (227)
gefitinib (194)
panitumumab (123)
lapatinib (107)
neratinib (102)
pyrotinib (79)
brigatinib (50)
icotinib (45)
aumolertinib (39)
amivantamab-vmjw (25)
furmonertinib (14)
mobocertinib (12)
lazertinib (12)
BGB-283 (12)
tarloxotinib bromide (7)
WZ4002 (7)
CH7233163 (6)
H002 (6)
nimotuzumab (6)
BLU-945 (6)
ASLAN001 (6)
BBT-176 (5)
CL-387785 (5)
GB263T (5)
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BPI-361175 (1)
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abivertinib (1)
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S-222611 (1)
HMPL-813 (1)
SI-B001 (1)
ASK120067 (1)
SH-1028 (1)
HLX07 (1)
Hemay022 (1)
KD019 (1)
ABT-101 (0)
AC480 (0)
AG1478 (0)
BBT-207 (0)
BC3448 (0)
BMS690514 (0)
CM93 (0)
CUDC-101 (0)
EGF-PTI (0)
DF9001 (0)
DK210 (0)
STI-001 (cetuximab biosimilar) (0)
FHND9041 (0)
HLX35 (0)
HS-10375 (0)
antroquinonol (0)
zalutumumab (0)
IAE0972 (0)
IBI-334 (0)
JANX008 (0)
JNJ-26483327 (0)
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rindopepimut (0)
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XZP-5809 (0)
simotinib (0)
ZN-e4 (0)
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cetuximab biosimilar (0)
cipatinib (0)
ABT-806 (0)
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PF-06747775 (0)
JNJ-64041757 (0)
KBP-5209 (0)
SKLB-1028 (0)
AZD8931 (0)
M7824 (9)
luspatercept-aamt (4)
CU01 (1)
AMUN-003 (0)
BMS-986416 (0)
BPB-101 (0)
CRB-601 (0)
JS201 (0)
JYB1907 (0)
Oxy210 (0)
PM8001 (0)
SAR439459 (0)
SD 093 (0)
SD 208 (0)
TQB2858 (0)
TQB2868 (0)
sotatercept (0)
ZGGS18 (0)
GT90001 (0)
AGEN1423 (0)
KER-050 (0)
GC 1008 (0)
cetuximab (347)
osimertinib (301)
erlotinib (235)
afatinib (227)
gefitinib (194)
panitumumab (123)
lapatinib (107)
neratinib (102)
pyrotinib (79)
brigatinib (50)
icotinib (45)
aumolertinib (39)
amivantamab-vmjw (25)
furmonertinib (14)
mobocertinib (12)
lazertinib (12)
BGB-283 (12)
tarloxotinib bromide (7)
WZ4002 (7)
CH7233163 (6)
H002 (6)
nimotuzumab (6)
BLU-945 (6)
ASLAN001 (6)
BBT-176 (5)
CL-387785 (5)
GB263T (5)
rociletinib (5)
BDTX-189 (5)
AEE788 (4)
BDTX-1535 (4)
BI-4020 (4)
tomuzotuximab (4)
JIN-A02 (4)
TAS2940 (4)
VRN11 (4)
MET306 (4)
EGF816 (4)
AFM24 (3)
BLU-701 (3)
GC-1118A (3)
MCLA-129 (3)
necitumumab (3)
befotertinib (3)
S95026 (3)
ASP8273 (3)
DZD9008 (3)
SZMD4 (3)
AZD3759 (3)
ACE2016 (2)
BI-732 (2)
BLU-451 (2)
Bay846 (2)
ERAS-801 (2)
OBX02-011 (2)
olmutinib (2)
QL1203 (2)
CLN-081 (2)
14aj (1)
ABN202 (1)
ABP 494 (cetuximab biosimilar) (1)
APL-103 (1)
BAY 2927088 (1)
BPI-15086 (1)
BPI-361175 (1)
Compound 6a (1)
abivertinib (1)
KKI04 (1)
PH001 (1)
TAS3351 (1)
TRX-221 (1)
WSD0922 (1)
JMT101 (1)
S-222611 (1)
HMPL-813 (1)
SI-B001 (1)
ASK120067 (1)
SH-1028 (1)
HLX07 (1)
Hemay022 (1)
KD019 (1)
ABT-101 (0)
AC480 (0)
AG1478 (0)
BBT-207 (0)
BC3448 (0)
BMS690514 (0)
CM93 (0)
CUDC-101 (0)
EGF-PTI (0)
DF9001 (0)
DK210 (0)
STI-001 (cetuximab biosimilar) (0)
FHND9041 (0)
HLX35 (0)
HS-10375 (0)
antroquinonol (0)
zalutumumab (0)
IAE0972 (0)
IBI-334 (0)
JANX008 (0)
JNJ-26483327 (0)
JS111 (0)
MM-151 (0)
MP412 (0)
MTX-211 (0)
NX-019 (0)
PF-08046052 (0)
PLB1004 (0)
PM1080 (0)
QLH11811 (0)
rindopepimut (0)
SR13668 (0)
SYN004 (0)
Sym013 (0)
TAK-186 (0)
TAK-285 (0)
TAS-121 (0)
TAVO412 (0)
TQ-B3456 (0)
TQB3804 (0)
TY-9591 (0)
U3-1565 (0)
Undisclosed EGFR inhibitor (0)
XZP-5809 (0)
simotinib (0)
ZN-e4 (0)
AST1306 (0)
SY101 (0)
Ami-LC (0)
EMB-01 (0)
cetuximab biosimilar (0)
cipatinib (0)
ABT-806 (0)
MEHD7945A (0)
RO5083945 (0)
TL007 (0)
EMD 72000 (0)
PF-06747775 (0)
JNJ-64041757 (0)
KBP-5209 (0)
SKLB-1028 (0)
AZD8931 (0)
M7824 (9)
luspatercept-aamt (4)
CU01 (1)
AMUN-003 (0)
BMS-986416 (0)
BPB-101 (0)
CRB-601 (0)
JS201 (0)
JYB1907 (0)
Oxy210 (0)
PM8001 (0)
SAR439459 (0)
SD 093 (0)
SD 208 (0)
TQB2858 (0)
TQB2868 (0)
sotatercept (0)
ZGGS18 (0)
GT90001 (0)
AGEN1423 (0)
KER-050 (0)
GC 1008 (0)
›
Associations
(3)
News
Trials
Search handles
Search handles
Filter by
Latest
10ms
👍 BCA101 🙌 combined with Pembrolizumab video https://t.co/bj62xHP0HP shows positive results in treating metastatic Head and Neck cancer. @HeadNeckMD promising combo therapy brings hope for improved outcomes. #CancerResearch #BCA101 #Pembrolizumab #HeadAndNeckCancer #ASCO23 (@oncologytube)
10 months ago
Video • Metastases
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
11ms
Encouraging anti-tumor activity for patients w/metastatic head & neck squamous cell carcinoma who are HPV-negative and treated with bifunctional EGFR/TGFβ inhibitor BCA101 w/pembrolizumab. Dose expansion results reported by @DanaFarber's Glenn Hanna, MD, (@HeadNeckMD) at #ASCO23. (@DanaFarberNews)
11 months ago
Clinical • Metastases
|
EGFR (Epidermal growth factor receptor) • TGFB1 (Transforming Growth Factor Beta 1)
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
11ms
Very promising activity observed with BCA101 + pembro in p16 negative cps 1-19% 1st line R/M HNSCC. Exceptional presentation by @HeadNeckMD at #ASCO23 (@AhernandoCalvo)
11 months ago
CDKN2A negative
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
11ms
@HeadNeckMD presenting BCA101 and pembrolizumab combination data in r/m hnscc. (@YilmazMDPhD)
11 months ago
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
11ms
📢 ASCO 2023 🎉 🔬 "BCA101 - The Potential of BCA101 in Cancer Treatment," sheds light on the cutting-edge research and innovative therapeutic strategies presented by 👨⚕️ Dr. @YilmazMDPhD at #ASCO23. @CleClinicMD #BCA101 #HeadandNeckCancer #ASCO23 📎 https://t.co/JkQq8a7T0V (@oncologytube)
11 months ago
ficerafusp alfa (BCA101)
12ms
Amazing work by BICARA team. Oral presentation @ASCO2023. BCA101 Pembrolizumab for metastatic HNSCC. New horizons. @HeadNeckMD @MoffittNews https://t.co/YsPtArgV30 (@JMuzaffarMD)
12 months ago
Metastases
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
over1year
@HeadNeckMD at #ESMO22: BCA101, first-in-class bifunctional EGFR/TGFβ fusion protein, is well tolerated and clinically active +/- pembro in pts with advanced solid tumors. - 1/40 (2,5%) PR, 13/40 (33%) SD in BCA101 pts. - 4/13 (31%) PR, DCR of 9/13 (69%) in BCA101 +/- pembro pts. (@wearemedsir)
over 1 year ago
Clinical
|
EGFR (Epidermal growth factor receptor) • TGFB1 (Transforming Growth Factor Beta 1)
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
over3years
well this is interesting.. option for those w/ dual KRAS & HER2 mutations? Study of Safety & Tolerability of BCA101 Alone & in Combination W/ Pembrolizumab in Patients W/ EGFR-driven Advanced Solid Tumors 292 pts, Phase 1 PI: @FilipJankuMD @MDAndersonNews https://t.co/dP5IFyqPiO (@fireflyann)
over 3 years ago
Clinical • PD(L)-1 Biomarker
|
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase)
|
HER-2 mutation
|
Keytruda (pembrolizumab) • ficerafusp alfa (BCA101)
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