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CANCER:
Astrocytoma
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News alerts, weekly reports and conference planners
Related cancers:
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Glioma (537
)
Anaplastic Astrocytoma (13
)
Glioma (537
)
Anaplastic Astrocytoma (13
)
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Associations
(74)
News
Trials
Search handles
@VivekSubbiah
@bpshah79
Search handles
@VivekSubbiah
@bpshah79
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Latest
9ms
Thank you Marcelo. It seems that fusion in BRAF is rare - 0.3 % in all cancers. Chiefly seen in melanoma, prostate and gastric. The only enriched cancer is pilocytic astrocytoma (85%). Does that seem right? (@bpshah79)
9 months ago
BRAF (B-raf proto-oncogene)
10ms
I’ve heard of a few in my fb astrocytoma group getting it approved via compassionate use for recurrence though don’t know their details. I’m definitely sitting at the edge of my chair with anticipation! (@elyons822)
10 months ago
1year
Diffuse Astrocytoma, MYB,MYBL1 altered (@Dr_Remisha)
1 year ago
MYBL1 (MYB Proto-Oncogene Like 1)
1year
Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation https://t.co/TFUmGJvvf7 (@VivekSubbiah)
1 year ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
1year
Fantastic, I love hearing about the progress you’re making. My daughter has (extremely unusually) a juvenile pilocytic astrocytoma with concomitant Kras and braf class iii mutations so I read your articles and tweets v closely. Thanks for sharing on Twitter (@schoolrunagain)
1 year ago
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
BRAF mutation
over1year
BRAF V600E mutation. Also seen in Pilocytic astrocytoma, PXA, Ganglioglioma, papillary craniopharyngioma, sessile serrated polyps etc (@DrSuryaReshmi95)
over 1 year ago
BRAF (B-raf proto-oncogene)
|
BRAF V600E • BRAF V600
over1year
⭐️Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation https://t.co/MtXO5hNh79 (@VivekSubbiah)
over 1 year ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
over1year
Hope this gets approved for IDH1 mutated astrocytoma soon 🤞 (@CancerFinalGirl)
over 1 year ago
IDH1 (Isocitrate dehydrogenase (NADP(+)) 1)
|
IDH1 mutation
over1year
Tuberous Sclerosis: 1. Angiomyolipoma of the kidney 2. Subependymal giant cell astrocytoma of the brain (I guess this is GFAP stain?) 3. Lymphangioleiomyomatosis of the lung 4. Angiofibroma of the skin 🧬TSC1 gene on ch 9, TSC2 gene on ch16 (@LeenQ10)
over 1 year ago
TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1) • GFAP (Glial Fibrillary Acidic Protein)
over1year
Pleomorphic xanthoastrocytoma. BRAF mutation and homozygous CDKN2A and/or B deletion. (@GustavoGaravag4)
over 1 year ago
BRAF (B-raf proto-oncogene) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A)
|
BRAF mutation • CDKN2A deletion • CDKN2A mutation
over1year
Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation @JCOPO_ASCO @OncoAlert https://t.co/ZTMuhGaHFs (@VivekSubbiah)
over 1 year ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation https://t.co/iohL3nwSC1 (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
Intravascular thrombi; IDH wildtype astrocytoma, most likely CNS WHO grade 4 and therefore GBM (depending on presence of necrosis, MVP, p-TERT mutation, EGFR amp, and/or chr7+/chr10-). (@CheySlocum)
almost 2 years ago
EGFR (Epidermal growth factor receptor) • TERT (Telomerase Reverse Transcriptase) • MVP (Major Vault Protein)
|
EGFR mutation • TERT mutation • IDH wild-type
almost2years
🎯🧬Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation https://t.co/YItXLXO6yJ (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
⭐️Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation @JCOPO_ASCO https://t.co/rx2Q1IHlrI (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
⭐️Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation 🧬🎯@JCOPO_ASCO #BrainTumorAwarenessMonth @OncoAlert https://t.co/MKufdJmW9p (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
⭐️Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1 N546K Mutation https://t.co/W4Ch7h3jhk (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
🚨⭐️Hot off the press in time for #BrainTumorAwarenessMonth 👉🏼Activity of Pemigatinib in Pilocytic Astrocytoma & FGFR1 N546K Mutation #PrecisionMedicine 🧬🎯! Loved working w budding future neurology resident @stephencaponemd @JCOPO_ASCO @OncoAlert https://t.co/HinpzGGpIn (@VivekSubbiah)
almost 2 years ago
FGFR1 (Fibroblast growth factor receptor 1)
|
FGFR1 mutation
|
Pemazyre (pemigatinib)
almost2years
MSH3-Associated Polyposis 🧰1st reported in 2016 in 2 families each w/2 affected siblings 🧰Colorectal & duodenal adenomas, colorectal cancer, gastric cancer, & an early-onset astrocytoma 🧰IHC absence of MSH3 🧰Tumors had eMAST 🧰PMID: 27476653 #ColorectalCancerAwarenessMonth (@HHampel1)
almost 2 years ago
MSH3 (MutS Homolog 3)
2years
IDH mutant astrocytoma . need to do NGS and DNA methylation profile to look for CDKN2A homozygos deletion or other specific alterations. (@RawiaMo57385655)
2 years ago
Next-generation sequencing • Epigenetic controller
|
CDKN2A (Cyclin Dependent Kinase Inhibitor 2A)
|
CDKN2A deletion
2years
➡️ORR ✅FGFR fusions =25.0% ✅FGFR mutations =23.1% ✅partial responses in ➡️cholangiocarcinoma, head and neck, pancreatic, gallbladder, uterine, urothelial carcinoma, recurrent pilocytic astrocytoma, & non-small cell lung cancer @OncoAlert (@VivekSubbiah)
2 years ago
Clinical
|
FGFR (Fibroblast Growth Factor Receptor)
|
FGFR mutation • FGFR fusion
2years
✅Partial responses were achieved in cholangiocarcinoma, head and neck,, pancreatic, gallbladder, uterine, urothelial carcinoma, recurrent pilocytic astrocytoma, & non-small cell lung cancer w FGFR alterations (@VivekSubbiah)
2 years ago
Clinical
|
FGFR (Fibroblast Growth Factor Receptor)
almost3years
MSH3-Associated Polyposis 🧰1st reported in 2016 in 2 families each w/2 affected siblings 🧰Colorectal & duodenal adenomas, colorectal cancer, gastric cancer, & an early-onset astrocytoma 🧰IHC absence of MSH3 🧰Tumors had eMAST 🧰PMID: 27476653 #ColorectalCancerAwarenessMonth (@HHampel1)
almost 3 years ago
MSH3 (MutS Homolog 3)
3years
What Is the Role of CDKN2A/B Homozygous Deletion in IDH–Mutant Astrocytoma? Dr. Sani H. Kizilbash answers in-depth for #ASCODailyNews https://t.co/9d4MtW0szA #BTSM (@ASCO)
3 years ago
CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B)
|
CDKN2A deletion
over3years
KIAA1549-BRAF fusion in pilocytic astrocytoma. Beautiful example of the fusion in IGV (integrated genomics viewer). #MolPathMonday #MolPath #neuropath (@LJTafeMD)
over 3 years ago
BRAF (B-raf proto-oncogene) • KIAA1549
|
KIAA1549-BRAF fusion • BRAF fusion
over3years
We have a new patient in @colontown with a MKRN1-BRAF fusion. Anyone come across this one? Would targeted therapy against BRAFV600E work in this case? https://t.co/YLIJBSKBdt https://t.co/WeLMBQm9KG Found in pilocytic astrocytoma (@manjuggm)
over 3 years ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF V600E • BRAF V600 • BRAF fusion
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