^
    11ms
    @aadel_chaudhuri @SitemanCenter highlights interesting findings of plasma #cfDNA in AR/enhancer loci (not just AR-V7) and can infer stem-cell like and transcriptional signatures in #mCRPC prognostic of worse outcomes. Day 2 of @PCFnews @PCF_Science Coffee-Holden #PCFAcademy (@jgong15)
    AR (Androgen receptor)
    |
    AR splice variant 7
    1year
    Interesting review, AR-V7 target genes promote #prostatecancer progression by driving a more aggressive phenotype by activating multiple biological pathways. @SbrtSean @Uro_MedUniWien @DrValladaresP https://t.co/UWiLWFT2uU (@Dr_Ivanoncologo)
    Review
    |
    AR (Androgen receptor)
    |
    AR splice variant 7
    over1year
    @mishabeltran on implementing molecular tests with predictive biomarkers in clinical practice. #decipher #ARv7. #psma doesn’t do the job in all cases. #norprost #prostatecancer biomarkers symposium (@AUrbanucci)
    Clinical
    |
    AR (Androgen receptor)
    |
    AR splice variant 7
    almost2years
    We have previously shown: ONC201 Monotherapy Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Enzalutamide-Resistant Prostate Cancer https://t.co/gdEGOURnte (@weldeiry)
    AR (Androgen receptor)
    |
    AR splice variant 7
    |
    everolimus • Xtandi (enzalutamide capsule) • dordaviprone (ONC201)
    almost2years
    Addition of samotolisib to #enzalutamide shows acceptable tolerability and clinical benefit in some patients with #mCRPC, esp. those who are androgen receptor splice variant 7 negative. https://t.co/Y8AR04vLSa @ChrisSweens1 @DavidMorrismd (@CCR_AACR)
    Clinical
    |
    AR (Androgen receptor)
    |
    AR splice variant 7 • AR-V7 negative
    |
    Xtandi (enzalutamide capsule) • samotolisib (LY3023414)
    2years
    The impact of AR-V7 and other androgen receptor splice variant expression on outcomes of post-prostatectomy salvage #therapy. A great presentation by MD. Keisuke Otani, Congratulations!! 🎉🎊 #ASCO #GU22 @ASCO @AscoOsig @CityofHope_GU @genitouro @Samirabellil @DanaFarber_GU (@Dr_Ivanoncologo)
    AR (Androgen receptor)
    |
    AR expression • AR splice variant 7