AR expression

📊AR expression in breast tumors: Unlike routine assessment of ER, PR, and HER2, current guidelines do not support the regular evaluation of AR. Most AR expression studies have used IHC with positive expression defined as staining ≥1% or 10% of the cells. (@s_santiesteban)

🧬𝗔𝗻𝗱𝗿𝗼𝗴𝗲𝗻 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿𝘀 (𝗔𝗥) 𝗶𝗻 𝗕𝗿𝗲𝗮𝘀𝘁 𝗖𝗮𝗻𝗰𝗲𝗿 🧵(1/) A high proportion of malignant breast tumors express androgen receptors, but the interaction of AR with different signaling pathways makes it difficult to interpret their tumoral activity #bcsm (@s_santiesteban)

70-85% of breast cancers express AR A difference in AR expression has consistently been found according to ER, PR, and HER2 status by IHC and molecular subtype: https://t.co/9jBuFVlEun https://t.co/EDrplpddzv (@s_santiesteban)

Androgen Receptor Expression Is a Predictor of Poor Outcome in Urothelial Carcinoma. AR is a targetable alteration - trials are currently ongoing ⁦@tompowles1⁩ ⁦@BartsECMC⁩ https://t.co/n10rRaomp5 (@b_szabados)

The impact of AR-V7 and other androgen receptor splice variant expression on outcomes of post-prostatectomy salvage #therapy. A great presentation by MD. Keisuke Otani, Congratulations!! 🎉🎊 #ASCO #GU22 @ASCO @AscoOsig @CityofHope_GU @genitouro @Samirabellil @DanaFarber_GU (@Dr_Ivanoncologo)

“3) lack of AR expression does not necessitate acquiring a NE phenotype despite concomitant mutations/deletions in PTEN and TP53, and loss of RB1, but can occur via emergence of an AR-/NE- double negative prostate cancer (DNPC)” 2/3 (@Dr_RaviMadan)

Endometrioid #Endometrialcancer has androgen receptor expression levels consistent with what is observed in prostate cancer - which makes this target very interesting to explore... #SGOMtg #gyncsm (@ShannonWestin)

We’ve known for a while that brain tumors sometimes express the androgen receptor. This is the key protein that makes prostate cancers grow but has more recently been found to make them (and some breast cancers! @cwspeers @michmer4 !) resistant to radiation @DrSpratticus 2/8 (@DanWahlMD)

Castration-recurrent #prostatecancer cells have a high level of androgen receptor expression in spite of a patient’s castrate status. #Urologists are exploring how to better inhibit the development of androgens. @jamesmohlermd discusses here: https://t.co/OCiOqJCqKI (@GRUrology)