^
    almost2years
    @DrHendifar @PancPathologist have had success w/ #ALK fusion in metastatic #PDAC following #FOLFIRINOX responsive to #alectinib then acquired alectinib-resistant ALK mutations G1202R and V1180L on G360, then w/benefit to 3rd-gen ALK inh #lorlatinib https://t.co/JnI2dntOfv #pancsm ()
    ALK (Anaplastic lymphoma kinase)
    |
    ALK fusion • ALK mutation • ALK G1202R • ALK V1180L
    |
    Guardant360® CDx
    |
    5-fluorouracil • Alecensa (alectinib) • Lorbrena (lorlatinib) • leucovorin calcium