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BIOMARKER:
ALK translocation
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EML4-ALK fusion (27)
ALK fusion (23)
EML4-ALK variant 3 (8)
STRN-ALK fusion (5)
ALK-HIP1 fusion (4)
EML4-ALK L1196M (4)
FN1-ALK fusion (4)
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
EML4-ALK variant 1 (3)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
RANBP2-ALK fusion (3)
SLC8A1-ALK fusion (3)
ALK-EML4_V5 (2)
ALK-HLA-DRB1 fusion (2)
CAD-ALK fusion (2)
CARS1‐ALK fusion (2)
CLTC-ALK fusion (2)
CMTR1-ALK fusion (2)
DCTN1-ALK fusion (2)
EML4-ALK C1156Y (2)
EML4-ALK G1202R (2)
EML4-ALK G1269A (2)
EML4-ALK I1171S (2)
EML4-ALK variant 2 (2)
HIP1-ALK I1171N (2)
KIF5B-ALK fusion (2)
LMO7-ALK fusion (2)
ACVR1-ALK fusion (1)
ALK-DCHS1 fusion (1)
ALK-EML4_V1 (1)
ALK-EML4_V2 (1)
ALK-EML4_V3 (1)
ALK-EML4_V5a (1)
ALK-KIF5B fusion (1)
ALK-LIMS1 fusion (1)
ALK-PPFIBP1 fusion (1)
ALK-ROS1 fusion (1)
CCDC6-ALK fusion (1)
CCDC85A-ALK fusion (1)
CLIP4-ALK fusion (1)
COX7A2L-ALK fusion (1)
CTNND1-ALK fusion (1)
CUX1-ALK fusion (1)
Chr t(2;17)(p23;q23) CLTC/ALK (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
EML4-ALK + ALK-PEX13 (1)
EML4-ALK E13;A20 (1)
EML4-ALK F1174C (1)
EML4-ALK I1171T (1)
EML4-ALK S1206Y (1)
EML4-ALK fusion + ALK-FEZ2 fusion (1)
EML4-ALK fusion + ALK-SSH2 fusion (1)
EML4-ALK fusion + ARID2-ALK fusion (1)
EML4-ALK fusion + CDK15-ALK fusion (1)
EML4-ALK variant 3a (1)
EML4-ALK variant 3b (1)
EML4_E13-ALK_E19 fusion (1)
EML4_E20-ALK_E19 fusion (1)
EML4_E6-ALK_E18(V3) (1)
EML6-ALK fusion + FBXO11-ALK fusion (1)
ERC1-ALK fusion (1)
GHR-ALK fusion (1)
HIVEP1-ALK fusion (1)
KANK4-ALK fusion (1)
KIDINS220-ALK fusion (1)
KIF13A-ALK fusion (1)
KLC1-ALK fusion (1)
KLHL31-LRRC1-ALK fusion (1)
LINC01173-ALK fusion + LOC388942-ALK fusion (1)
LOC101927285-ALK fusion (1)
LTBP1-ALK fusion (1)
LTBP1-ALK fusion + HIP1-ALK fusion (1)
LTBP1_E2-ALK_E11 fusion (1)
MPRIP-ALK fusion (1)
MRPS9-ALK fusion (1)
MYH9-ALK + ALK-WDR43 (1)
NBEA-ALK fusion + EML4-ALK fusion (1)
NKAIN2-ALK fusion (1)
NPM-ALK fusion (1)
PRKCB-ALK fusion (1)
PTH2R-ALK fusion (1)
RANBP2-ALK + TMEM217-ALK (1)
SDK1-ALK fusion (1)
SETD2-ALK fusion + EML4-ALK fusion (1)
SPECC1L‑ALK fusion (1)
STRN exon 2-ALK exon 20 fusion (1)
TFG-ALK fusion (1)
TNIP2-ALK fusion (1)
TOGARAM2-ALK fusion (1)
UGP2-ALK fusion (1)
CDK15-ALK fusion (0)
EML6-ALK fusion (0)
FBXO11-ALK fusion (0)
EML4-ALK fusion (27)
ALK fusion (23)
EML4-ALK variant 3 (8)
STRN-ALK fusion (5)
ALK-HIP1 fusion (4)
EML4-ALK L1196M (4)
FN1-ALK fusion (4)
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
EML4-ALK variant 1 (3)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
RANBP2-ALK fusion (3)
SLC8A1-ALK fusion (3)
ALK-EML4_V5 (2)
ALK-HLA-DRB1 fusion (2)
CAD-ALK fusion (2)
CARS1‐ALK fusion (2)
CLTC-ALK fusion (2)
CMTR1-ALK fusion (2)
DCTN1-ALK fusion (2)
EML4-ALK C1156Y (2)
EML4-ALK G1202R (2)
EML4-ALK G1269A (2)
EML4-ALK I1171S (2)
EML4-ALK variant 2 (2)
HIP1-ALK I1171N (2)
KIF5B-ALK fusion (2)
LMO7-ALK fusion (2)
ACVR1-ALK fusion (1)
ALK-DCHS1 fusion (1)
ALK-EML4_V1 (1)
ALK-EML4_V2 (1)
ALK-EML4_V3 (1)
ALK-EML4_V5a (1)
ALK-KIF5B fusion (1)
ALK-LIMS1 fusion (1)
ALK-PPFIBP1 fusion (1)
ALK-ROS1 fusion (1)
CCDC6-ALK fusion (1)
CCDC85A-ALK fusion (1)
CLIP4-ALK fusion (1)
COX7A2L-ALK fusion (1)
CTNND1-ALK fusion (1)
CUX1-ALK fusion (1)
Chr t(2;17)(p23;q23) CLTC/ALK (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
EML4-ALK + ALK-PEX13 (1)
EML4-ALK E13;A20 (1)
EML4-ALK F1174C (1)
EML4-ALK I1171T (1)
EML4-ALK S1206Y (1)
EML4-ALK fusion + ALK-FEZ2 fusion (1)
EML4-ALK fusion + ALK-SSH2 fusion (1)
EML4-ALK fusion + ARID2-ALK fusion (1)
EML4-ALK fusion + CDK15-ALK fusion (1)
EML4-ALK variant 3a (1)
EML4-ALK variant 3b (1)
EML4_E13-ALK_E19 fusion (1)
EML4_E20-ALK_E19 fusion (1)
EML4_E6-ALK_E18(V3) (1)
EML6-ALK fusion + FBXO11-ALK fusion (1)
ERC1-ALK fusion (1)
GHR-ALK fusion (1)
HIVEP1-ALK fusion (1)
KANK4-ALK fusion (1)
KIDINS220-ALK fusion (1)
KIF13A-ALK fusion (1)
KLC1-ALK fusion (1)
KLHL31-LRRC1-ALK fusion (1)
LINC01173-ALK fusion + LOC388942-ALK fusion (1)
LOC101927285-ALK fusion (1)
LTBP1-ALK fusion (1)
LTBP1-ALK fusion + HIP1-ALK fusion (1)
LTBP1_E2-ALK_E11 fusion (1)
MPRIP-ALK fusion (1)
MRPS9-ALK fusion (1)
MYH9-ALK + ALK-WDR43 (1)
NBEA-ALK fusion + EML4-ALK fusion (1)
NKAIN2-ALK fusion (1)
NPM-ALK fusion (1)
PRKCB-ALK fusion (1)
PTH2R-ALK fusion (1)
RANBP2-ALK + TMEM217-ALK (1)
SDK1-ALK fusion (1)
SETD2-ALK fusion + EML4-ALK fusion (1)
SPECC1L‑ALK fusion (1)
STRN exon 2-ALK exon 20 fusion (1)
TFG-ALK fusion (1)
TNIP2-ALK fusion (1)
TOGARAM2-ALK fusion (1)
UGP2-ALK fusion (1)
CDK15-ALK fusion (0)
EML6-ALK fusion (0)
FBXO11-ALK fusion (0)
›
Related tests:
Lung Cancer 8-Gene Kit
Lung Cancer 8-Gene Kit
Associations
(9)
News
Trials
Search handles
@CharuAggarwalMD
@FordePatrick
@Jbauml
@UroDocAsh
@ViktorGruenwald
@VinciusLorandi1
@montypal
Search handles
@CharuAggarwalMD
@FordePatrick
@Jbauml
@UroDocAsh
@ViktorGruenwald
@VinciusLorandi1
@montypal
Filter by
Latest
over1year
Pt in her early 40s, extensively metastatic lung cancer, “no target” on a few diff attempts at DNA seq (editorializing - please don’t biopsy bone for lung cancer diagnosis!) or liquid biopsy, repeat tissue biopsy & RNA seq = EML4-ALK translocation! Christmas came early! #lcsm (@FordePatrick)
over 1 year ago
Liquid biopsy
|
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
ALK translocation
over1year
Very nice tool for selecting treatment for both ALK and ROS translocations #NSCLC #lungcancer #gbot https://t.co/Otzs3Gqr6A (@VinciusLorandi1)
over 1 year ago
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
over1year
Very nice tool for selecting treatment for both ALK and ROS translocations #NSCLC #lungcancer #gbot https://t.co/Otzs3GpTh2 (@VinciusLorandi1)
over 1 year ago
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
almost2years
👏 to Holger and colegues. New classification of RCC: 👉New morphological entity: eosinophilic & cystic RCC 👉New molecular-defined RCC: ELOC-mutated, ALK-translocation, SMARCB1, TFEB-altered, FH-deficient 👉New: pRCC is 1 entity only https://t.co/bdjyk1OBPf (@ViktorGruenwald)
almost 2 years ago
ALK (Anaplastic lymphoma kinase) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • TFEB (Transcription Factor EB 2)
|
ALK translocation
over2years
Our series supports organ sparing therapy for patients with localized inflammatory myofibroblastic tumors of the bladder. Extirpative surgery only for refractory cases; crizotinib for metastatic disease with ALK translocation https://t.co/EJ3co2O1Ut @pjhensley11 @CurtisPettaway1 (@UroDocAsh)
over 2 years ago
Clinical
|
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
|
Xalkori (crizotinib)
over2years
Our real world analysis of the prevalence of ALK translocations. While rare, 21.6% of young pts with lung cancer had an ALK mutation. Biomarker panel testing is necessary and urgent at diagnosis. #LCSM #ALK hahttps://www.oncotarget.com/article/28114/text/#.YY0laOE_zMo.twitter (@EricBernicker)
over 2 years ago
Clinical • Real-world evidence
|
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
over2years
About 5% of tumors are ALK which are generally tic inversions or translocations in #lungcancer says @GRSimonMD with cochairs @edgardo_ny @LuisERaez1 and Dr Chiappori @OncLiveSOSS #ipc #lcsm @AdventHealth @MoffittNews (@donnashort)
over 2 years ago
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
3years
NEED HELP: writing commentary on ALK-directed tx in non-NSCLC tumors. Anytone know if @theNCI MATCH trial arm for ALK translocation has been reported? Per websute seems like accrual complete in 2015. Also for @EORTC CREATE, anyone know where the non-PRCC type1 arms are published? (@montypal)
3 years ago
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
over3years
These curves are the difference in OS outcomes based on out of pocket costs for #LungCancer w/ #EGFR Mt or #ALK translocations. Small numbers, but these data are very instructive. We need to support our pts better @EGFRResisters @ALKLungCancer @alk_fusion @ASCO_pubs #JCOOP #LCSM (@CharuAggarwalMD)
over 3 years ago
Clinical
|
EGFR (Epidermal growth factor receptor) • ALK (Anaplastic lymphoma kinase)
|
ALK fusion • ALK translocation
almost4years
We now have two FDA approved treatments for the 1L management of NSCLC harboring an ALK translocation. This is an interesting one - the toxicity profile of the two drugs is very different in my experience, so there could be a role for both here. (@Jbauml)
almost 4 years ago
FDA event
|
ALK (Anaplastic lymphoma kinase)
|
ALK translocation
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