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    BIOMARKER:

    ALK L1196M

    i
    Other names: NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
    Entrez ID:
    238
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    2years
    Report in @ESMO_Open on liquid biopsy results post TKI therapy for 116 pts with #ALK fusion+ NSCLC. G1202R resistance mutation more common in EML4-ALK fusion variant 3, L1196M more in v1. More compound and complex mutations seen with use of multiple TKIs. https://t.co/ID201mkX4C (@StephenVLiu)
    Clinical • Liquid biopsy
    |
    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
    |
    EML4-ALK fusion • ALK fusion • ALK G1202R • EML4-ALK L1196M • ALK L1196M • EML4-ALK G1202R
    over3years
    #OncoAlert Report @JTOonline @IASLC on phase II #ATOMIC study of brigatinib in #ALK NSCLC after next-gen ALK TKI therapy. RR 40%, DOR 5.3m, mPFS 7m. Responses seen with ALK resistance mutations (G1202R, I1171T, L1196M). @rdoebele @HornLeora #LCSM https://t.co/aoWJ1Gu0NP (@StephenVLiu)
    ALK (Anaplastic lymphoma kinase)
    |
    ALK mutation • ALK G1202R • ALK I1171T • ALK I1171 • ALK L1196M • ALK L1196M + ALK G1202R
    |
    Alunbrig (brigatinib)
    almost4years
    #ASCO20 Response to brigatinib (post-alectinib) noted in the presence of various #ALK resistance mutations including G1202R (1/3), L1196M (3/3), I1171N (1/2), I1171S (1/1). Well tolerated. Most common G3 tox were lipase (no pancreatitis), CK (no myalgias), HTN. #OncoAlert #LCSM (@StephenVLiu)
    ALK (Anaplastic lymphoma kinase)
    |
    ALK mutation • ALK G1202R • ALK I1171N • ALK I1171 • ALK L1196M • ALK I1171S • ALK L1196M + ALK G1202R
    |
    Alecensa (alectinib) • Alunbrig (brigatinib)