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BIOMARKER:
AKT1 mutation
i
Other names:
AKT1, AKT, PKB, PRKBA, RAC, V-akt murine thymoma viral oncogene homolog 1
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Entrez ID:
207
Related biomarkers:
Expression
Mutation
CNA
Others
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Associations
(6)
News
Trials
Search handles
@neerajaiims
Search handles
@neerajaiims
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almost2years
Agree with importance of accurately defining AKT1 and PIK3CA status in mCRPC and yes seems like there is a spectrum of oncogenic addiction. e.g. MMRd/MSI-H tumors often accrue AKT1/PIK3CA mutations, but they are likely to have plenty of redundancy. https://t.co/czhdQVKRdy (@ResearchWyatt)
almost 2 years ago
PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MSI (Microsatellite instability) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)
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MSI-H/dMMR • PIK3CA mutation • AKT1 mutation
3years
#GU21 @ASCO Updated results from IPATential trial metastatic CRPC #ProstateCancer 👉Pts with genomic mutations in PIK3CA/AKT1/PTEN had a ⬆️ magnitude of rPFS benefit with ipat + abi than without👇https://t.co/sfPU49vbh1 @OncoAlert @urotoday Next trial need genomic selection (@neerajaiims)
3 years ago
Clinical
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PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)
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PIK3CA mutation • PTEN mutation • AKT1 mutation
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