^
    CANCER:

    Uveal Melanoma





    Show legend
    Group by Gene:
    Include preclinical:

    dacarbazine
    melphalan hepatic delivery system
    		0
    DNA synthesis inhibitor
    temozolomide
    bleomycin
    cisplatin
    PD1 inhibitor
    		1
    PD1 inhibitor
    pembrolizumab
    nivolumab
    2
    MEK inhibitor
    trametinib
    selumetinib
    3
    CTLA4 inhibitor
    CTLA4 inhibitor
    ipilimumab
    4
    PD1 inhibitor, CTLA4 inhibitor
    nivolumab + ipilimumab
    pembrolizumab + ipilimumab
    5
    Bcl2 inhibitor, Tubulin inhibitor
    albumin-bound paclitaxel
    6
    gp100 inhibitor, CTLA4 inhibitor
    ipilimumab + tebentafusp-tebn
    7
    gp100 inhibitor
    tebentafusp-tebn
    AEB071
    		8
    PKC inhibitor
    IDE196
    AEB071 + AHT956
    9
    Multi-tyrosine kinase inhibitor
    cabozantinib capsule
    ponatinib
    10
    Immunotherapy
    Immunotherapy
    11
    PD-L1 inhibitor
    PD-L1 inhibitor
    12
    Chemotherapy
    TC
    CaT
    13
    FGFR inhibitor, EZH2 inhibitor
    FGFR inhibitor + EZH2 inhibitor
    14
    Tubulin polymerization promoter, Bcl2 inhibitor
    paclitaxel
    15
    HDAC inhibitor, HDAC1 inhibitor, PD1 inhibitor, HDAC2 inhibitor, HDAC3 inhibitor
    pembrolizumab + entinostat
    16
    THF dehydrogenase inhibitor, Arginine depleter, DNA synthesis inhibitor, Thymidylate synthase inhibitor
    cisplatin + pemetrexed + pegargiminase
    17
    GPNMB-targeted antibody-drug conjugate, Microtubule inhibitor
    CDX-011
    18
    cRAF inhibitor, PD1 inhibitor, MEK inhibitor, BRAF inhibitor
    pembrolizumab + binimetinib + encorafenib
    19
    MEK inhibitor, Reactive oxygen species stimulant, Apoptosis stimulant, HSP70 stimulant
    binimetinib + STA-4783
    20
    MEK2 inhibitor, MEK1 inhibitor
    REC-4881
    U0126
    21
    PI3K inhibitor, PKCβ inhibitor, AKT inhibitor
    enzastaurin
    22
    Topoisomerase II inhibitor
    zoptarelin doxorubicin
    23
    CDK inhibitor
    SNS-032
    24
    HDAC inhibitor
    JNJ 26481585
    25
    MEK inhibitor, PI3K inhibitor, mTOR inhibitor
    trametinib + GSK2126458
    26
    MEK inhibitor, mTOR inhibitor
    selumetinib + AZD8055
    27
    GNAQ inhibitor, NMT-1 inhibitor, NLRP3 inhibitor, ARF6 inhibitor
    Tris DBA
    28
    Gαq-11 protein inhibitor
    FR900359
    29
    MEK inhibitor, PKC inhibitor
    binimetinib + AEB071
    PD-0325901 + AEB071
    30
    MDM2 inhibitor, PKC inhibitor
    AEB071 + CGM097
    31
    Reactive oxygen species stimulant, Photosensitizer
    verteporfin
    32
    mTOR inhibitor, PKC inhibitor
    everolimus + AEB071
    33
    BET inhibitor
    JQ-1
    34
    Phospholipase A2 inhibitor, MEK inhibitor, Immunomodulator
    trametinib + hydroxychloroquine
    35
    Reactive oxygen species stimulant, Apoptosis stimulant, HSP70 stimulant
    STA-4783
    36
    Aurora kinase B inhibitor, Aurora kinase C inhibitor
    NMI-900
    37
    DNA synthesis inhibitor, DNA-directed DNAP inhibitor
    cytarabine
    38
    Topoisomerase I inhibitor
    camptothecin nanosomal
    39
    EphB4 inhibitor
    BHG712
    40
    CXCL12 inhibitor, Farnesyl transferase inhibitor
    tipifarnib
    41
    MEK inhibitor, Gαq-11 protein inhibitor, Purinergic receptor P2Y12 inhibitor
    MEK inhibitor + YM-254890
    No biomarker
    HLA-A*02:01
    GNAQ mutation
    GNAQ Q209L
    GNAQ G48V
    GNAQ R183Q
    GNAQ Q209P
    LDH-L
    GNA11 mutation
    MBD4 mutation
    GNA11 Q209L
    MBD4 L563T
    LDH elevation
    MBD4 deletion
    GOLM1 overexpression
    ASS1 negative
    IL6 elevation
    GNAQ G48L + FGFR4 C172G
    PCSK9 underexpression
    CXCL10 elevation
    GPNMB expression
    BRAF V600E
    GNAQ mutation + GNA11 mutation
    CYSLTR2 L129Q
    KDELR3 overexpression
    CDK9 overexpression
    BAP1 deletion
    GNRH1 expression
    BAP1 mutation
    CDK7 overexpression
    NRAS overexpression
    KRAS overexpression
    DDX43 overexpression