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    BIOMARKER:

    PTEN underexpression

    i
    Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM
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    Include preclinical:
    Chronic Lymphocytic Leukemia
    Hormone Receptor Positive Breast Cancer
    Pancreatic Cancer
    Chronic Myeloid Leukemia
    Breast Cancer
    Prostate Cancer
    ibrutinib
    tamoxifen
    trametinib + dabrafenib
    imatinib
    AZD1775
    copanlisib + darolutamide