^
    CANCER:

    Prostate Cancer





    Show legend
    Group by Gene:
    Include preclinical:

    olaparib
    rucaparib
    		0
    PARP inhibitor
    niraparib
    talazoparib
    IMP4297
    PARP inhibitor
    histrelin acetate
    triptorelin
    		1
    GnRH agonist
    leuprorelin depot
    leuprolide acetate
    leuprolide 6-month depot
    goserelin acetate
    enzalutamide capsule
    darolutamide
    		2
    Androgen receptor inhibitor
    bicalutamide
    SID 3712502
    enzalutamide capsule + EPI-7170
    Androgen receptor inhibitor
    leuprolide acetate + nilutamide
    histrelin acetate + nilutamide
    		3
    Androgen receptor antagonist, GnRH agonist
    goserelin acetate + nilutamide
    triptorelin + nilutamide
    leuprolide acetate + apalutamide
    abiraterone acetate + triptorelin
    		4
    CYP17A1 inhibitor, GnRH agonist
    abiraterone acetate + leuprolide acetate
    abiraterone acetate + histrelin acetate
    abiraterone acetate + goserelin acetate
    abiraterone acetate
    		5
    CYP17A1 inhibitor
    abiraterone acetate
    abiraterone acetate
    CYP17A1 inhibitor
    6
    Topoisomerase II inhibitor
    mitoxantrone
    etoposide IV
    7
    GnRH antagonist
    degarelix
    relugolix
    pembrolizumab
    		8
    PD1 inhibitor
    nivolumab
    PD1 inhibitor
    atezolizumab
    		9
    PD-L1 inhibitor
    avelumab
    durvalumab
    PD-L1 inhibitor
    apalutamide
    		10
    Androgen receptor antagonist
    EPI-7386
    BMS-641988
    11
    Microtubule inhibitor
    cabazitaxel
    12
    PD1 inhibitor, CTLA4 inhibitor
    nivolumab + ipilimumab
    13
    Topoisomerase II inhibitor, DNA inhibitor, DNA synthesis inhibitor
    cisplatin + etoposide oral
    14
    Bone resorption factor inhibitor, Osteoclast inhibitor
    zoledronic acid
    15
    Immunostimulant, Prostatic acid phosphatase inhibitor
    sipuleucel-T
    16
    Tubulin polymerization promoter, Microtubule inhibitor
    carboplatin + cabazitaxel
    17
    Ionizing radiation emitter, PSMA inhibitor
    PNT2002
    lutetium Lu 177 vipivotide tetraxetan
    18
    Androgen receptor degrader
    ARV-110
    AC0176
    19
    PI3K inhibitor, AKT inhibitor
    RG7440
    20
    mTOR inhibitor
    everolimus
    mTOR inhibitor
    21
    CTLA4 inhibitor
    ipilimumab
    22
    Androgen receptor inhibitor, PARP inhibitor
    talazoparib + enzalutamide capsule
    23
    PLK1 inhibitor
    PCM-075
    24
    Immunostimulant
    RV001
    25
    PD1 inhibitor, PARP inhibitor
    nivolumab + rucaparib
    pembrolizumab + olaparib
    26
    PD-L1 inhibitor, PARP inhibitor
    avelumab + talazoparib
    27
    Androgen receptor inhibitor, mTOR inhibitor, DNA PK inhibitor
    enzalutamide capsule + CC-115
    28
    PARP inhibitor, AKT inhibitor
    olaparib + capivasertib
    29
    HER2 inhibitor, HER2 dimerization inhibitor
    trastuzumab + pertuzumab
    30
    Tubulin polymerization promoter
    carboplatin
    31
    PI3Kβ inhibitor
    GSK2636771
    32
    MEK inhibitor
    trametinib
    PD-0325901
    33
    VEGFR inhibitor, PARP inhibitor
    olaparib + cediranib
    34
    DNA synthesis inhibitor
    cisplatin
    35
    PI3Kβ inhibitor, PD1 inhibitor
    pembrolizumab + GSK2636771
    36
    CYP11A1 inhibitor
    ODM-208
    docetaxel
    		37
    Microtubule stabilizer, Tubulin polymerization promoter
    carboplatin + docetaxel
    docetaxel
    leuprolide acetate + bicalutamide
    triptorelin + flutamide
    bicalutamide + triptorelin
    		38
    Androgen receptor inhibitor, GnRH agonist
    goserelin acetate + flutamide
    bicalutamide + goserelin acetate
    histrelin acetate + flutamide
    bicalutamide + histrelin acetate
    leuprolide acetate + flutamide
    39
    GnRH antagonist, CYP17A1 inhibitor
    abiraterone acetate + degarelix
    40
    Topoisomerase II inhibitor, Tubulin polymerization promoter, DNA inhibitor
    carboplatin + etoposide oral
    41
    PD-L1 inhibitor, Androgen receptor inhibitor
    atezolizumab + enzalutamide capsule
    42
    PIK3CA inhibitor, PARP inhibitor, PI3Kδ inhibitor
    rucaparib + copanlisib
    43
    PSMA-targeted antibody-drug conjugate, Tubulin inhibitor
    JNJ-8177
    44
    Androgen receptor degrader, Androgen receptor inhibitor
    ONCT-534
    45
    PD-L1 inhibitor, Multi-tyrosine kinase inhibitor
    atezolizumab + cabozantinib tablet
    46
    PARP2 inhibitor, PARP1 inhibitor, CYP17A1 inhibitor
    abiraterone / niraparib
    47
    PD1 inhibitor, Androgen receptor inhibitor
    pembrolizumab + enzalutamide capsule
    48
    IGF-2 inhibitor, Androgen receptor inhibitor, IGF1 inhibitor
    enzalutamide capsule + BI-836845
    49
    Ionizing radiation emitter, Androgen receptor inhibitor, PSMA inhibitor
    enzalutamide capsule + lutetium Lu 177 vipivotide tetraxetan
    50
    Ionizing radiation emitter, PD1 inhibitor, PSMA inhibitor
    pembrolizumab + lutetium Lu 177 vipivotide tetraxetan
    51
    CYP17A1 inhibitor, Androgen receptor inhibitor, Androgen receptor antagonist
    enzalutamide capsule + abiraterone acetate + apalutamide
    52
    STEAP1-targeted antibody-drug conjugate, Microtubule inhibitor
    RG7450
    53
    Alkylating agent
    cyclophosphamide
    STAR-001
    54
    Topoisomerase II inhibitor, DNA synthesis inhibitor
    etoposide IV + bleomycin
    55
    B7-H3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    DS-7300
    56
    Tubulin polymerization promoter, PARP inhibitor
    PARP inhibitor + carboplatin
    57
    PD-L1 inhibitor, PI3K inhibitor, AKT inhibitor
    atezolizumab + RG7440
    58
    STAT3 inhibitor, PD1 inhibitor
    pembrolizumab + BBI608
    59
    GnRH antagonist, CYP17A1 inhibitor, Androgen receptor antagonist
    abiraterone acetate + degarelix + bicalutamide implant
    60
    Topoisomerase II inhibitor, Microtubule stabilizer, Tubulin polymerization promoter, Bcl2 inhibitor
    paclitaxel + docetaxel + etoposide IV
    61
    Ferroptosis inducer
    RSL3
    erastin
    62
    Glutathione peroxidase 4 inhibitor, Ferroptosis inducer
    ML210
    63
    EZH1 inhibitor, EZH2 inhibitor
    CPI-0209
    64
    CDK4 inhibitor, CDK6 inhibitor
    abemaciclib
    palbociclib
    65
    Bcr-abl tyrosine kinase inhibitor
    INNO-406
    66
    FGFR2 inhibitor, FGFR inhibitor, FGFR1 inhibitor, FGFR3 inhibitor, FGFR4 inhibitor
    erdafitinib
    erdafitinib + Debio 1347
    67
    CXCL12 inhibitor, Farnesyl transferase inhibitor
    tipifarnib
    68
    AKT inhibitor
    MK-2206
    capivasertib
    69
    p53 reactivator
    APR-246
    APR-548
    70
    DNA replication inhibitor, PSMA-targeted antibody-drug conjugate
    MEDI3726
    ADCT-212
    71
    FGFR inhibitor, Androgen receptor inhibitor
    enzalutamide capsule + Debio 1347
    72
    CYP17A1 inhibitor, Androgen receptor inhibitor
    enzalutamide capsule + abiraterone acetate
    73
    Androgen receptor inhibitor, Microtubule inhibitor, PSMA-targeted antibody-drug conjugate
    enzalutamide capsule + PSMA ADC
    74
    CYP17A1 inhibitor, PI3K inhibitor, AKT inhibitor
    abiraterone acetate + RG7440
    75
    GnRH stimulant, CYP17A1 inhibitor, Androgen receptor antagonist
    abiraterone acetate + bicalutamide implant + leuprorelin depot
    76
    Microtubule stabilizer, Tubulin polymerization promoter, Microtubule inhibitor
    docetaxel + cabazitaxel
    77
    Ionizing radiation emitter
    radium Ra-223 dichloride
    78
    CD3 agonist, PSMA inhibitor
    JNJ-63898081
    79
    Chk1 inhibitor, Chk2 inhibitor
    ACR-368
    80
    PSMA-targeted CAR-T immunotherapy
    AUTO7
    81
    CD3 agonist, STEAP1 inhibitor
    AMG 509
    82
    Androgen receptor inhibitor, ERK inhibitor, AKT inhibitor
    darolutamide + ONC201
    83
    Adenosine A2A receptor antagonist, Androgen receptor antagonist
    apalutamide + AZD4635
    84
    Adenosine A2A receptor antagonist
    AZD4635
    85
    Bcr-abl tyrosine kinase inhibitor, mTOR inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib + AZD8055
    86
    CDK7 inhibitor
    YPN-005
    SY‑079
    87
    DOT1L inhibitor
    EPZ-5676
    EPZ004777
    88
    SLC44A4-targeted antibody-drug conjugate, Microtubule inhibitor
    ASG 5ME
    89
    MAPK inhibitor, p38 inhibitor
    SB202190
    90
    pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib
    91
    MEK2 inhibitor, MEK1 inhibitor
    U0126
    92
    PI3K inhibitor
    MEN1611
    93
    BTK inhibitor
    ibrutinib
    94
    Androgen receptor inhibitor, AKT inhibitor
    enzalutamide capsule + capivasertib
    95
    AKT2 inhibitor, AKT1 inhibitor
    BAY 1125976
    96
    Androgen receptor antagonist, TMPRSS2 inhibitor
    GT0918
    97
    Thymidylate synthase inhibitor
    5-fluorouracil
    98
    B7-H3-targeted antibody-drug conjugate, DNA replication inhibitor
    MGC018
    99
    ROR1 inhibitor
    UC-961
    100
    MEK1 inhibitor
    cobimetinib
    101
    Ionizing radiation emitter, CD37 inhibitor
    177Lu-satetraxetan-lilotomab
    102
    HER3 inhibitor, α radiation emission
    Ac-225 ErbB3 targeted radiotherapy
    103
    Aurora kinase A inhibitor
    MLN8237
    104
    Androgen receptor inhibitor, AR-V7 degrader
    enzalutamide capsule + HSK38008
    105
    AR-V7 degrader
    HSK38008
    106
    GPC-1-targeted antibody-drug conjugate
    anti-GPC-1 ADC
    107
    AXL-targeted antibody-drug conjugate, Microtubule inhibitor
    BA3011
    108
    CEACAM5-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    IMMU-130
    109
    ZG16B inhibitor
    PBP1510
    110
    PIK3CA inhibitor, Androgen receptor inhibitor, PI3Kδ inhibitor
    copanlisib + darolutamide
    111
    mTORC1 inhibitor
    mTORC1 inhibitor
    112
    Immunotherapy
    Immunotherapy
    113
    GnRH stimulant
    GnRH stimulant
    114
    Src kinase inhibitor, PARP inhibitor
    PARP inhibitor + Src kinase inhibitor
    115
    ATM kinase inhibitor
    ATM kinase inhibitor
    No biomarker
    BRCA2 mutation
    PTEN deletion
    PTEN mutation
    BRCA2 deletion
    BRCA2 positive
    PTEN negative
    PTEN N323fs*21
    PTEN overexpression
    BRCA2 biallelic inactivation
    BRCA2 A902fs*2
    PTEN expression
    BRCA2 underexpression
    BRCA2 amplification
    BRCA2 exon 11 deletion
    PTEN underexpression
    AR splice variant 7 negative
    AR wild-type
    AR mutation
    AR T878A
    AR overexpression
    AR H875Y
    AR elevation
    AR T878S + AR H875Y
    AR T878A + AR H875Y
    AR T878S
    AR L702H
    AR positive
    AR splice variant 7
    AR amplification
    AR F877L + AR T878A
    AR W741L
    AR W741C
    AR expression
    AR F877L
    AR T877A
    AR F876L
    AR splice variant 7 expression
    AR splice variant 9
    AR D891H
    AR H100Q
    AR L329W
    FANCL mutation
    BRCA1 mutation
    BRCA1 positive
    BRCA1 biallelic inactivation
    BRCA1 deletion
    BRCA1 underexpression
    PD-L1 overexpression
    PD-L1 expression
    ATM positive
    ATM mutation
    ATM deletion
    ATM underexpression
    ATM biallelic inactivation
    MSI-H/dMMR
    FOLH1 expression
    FOLH1 positive
    FOLH1 overexpression
    HRD
    CD8 expression
    SPOP mutation
    CDK12 mutation
    PALB2 mutation
    FANCA mutation
    MLH1 mutation
    BRCA2 deletion + ATM mutation
    CDK12 deletion
    FANCA deletion
    WRN mutation
    CYP17A1 expression
    MLH1 deletion
    PALB2 deletion
    BRCA2 mutation + ATM mutation
    WRN expression
    CYP17A1 V366M
    MSH2 negative + MSH6 negative
    MSH2 mutation + MSH6 mutation
    RB1 mutation
    PSMA1 overexpression
    BRCA1 mutation + ATM mutation
    TUBB1 rs151352
    CYP2C8 rs1341164
    SPOP mutation + CHD1 deletion
    ATR mutation
    BLM mutation
    PMS1 expression
    RAD51B mutation
    MLL2 mutation
    FANCE expression
    POLR2L expression
    CD19 overexpression
    PAX5 overexpression
    BRCA1 mutation + TP53 mutation
    BRCA2 mutation + TP53 mutation
    MSH2 deletion
    CYB5A rs1790834
    IGF1 overexpression
    TUBB3 overexpression
    FANCM mutation
    BRCA2 mutation + SPOP mutation
    MSI-H + MSH2 expression + MSH6 expression
    FANCI mutation
    CHEK1 mutation
    CHEK2 mutation
    AFP elevation
    MSI-H/dMMR + TMB-H
    FANCG mutation
    RAD50 mutation
    FANCF mutation
    PMS2 mutation + MLH1 mutation
    MSH2 mutation + MSH6 mutation + BRCA1 mutation
    HDAC2 mutation
    STEAP1 expression
    LRP1B mutation
    AKT1 mutation + AR mutation
    SND1-BRAF fusion
    CPM elevation
    Apolipoprotein B elevation
    TMB-H
    YBX1 rs10493112
    PD-L2 overexpression
    PD-1 overexpression
    BRIP1 mutation
    ATRX mutation
    HER-2 amplification
    BARD1 mutation
    RAD54L mutation
    RAD51D mutation
    RAD51C mutation
    SNAI2 deletion
    CD276 overexpression
    KDM5D overexpression
    RB1 deletion
    RB deletion
    CYP2C8 rs1058932
    RB1 expression
    PSMA1 expression
    KDM5D amplification
    CD276 expression
    TSG gene expression signature
    AR-V7 positive
    DDR
    AR-V7 expression
    AR-V7 negative
    AR-V7 mutation
    AXL expression
    PPP2R2A mutation
    CEACAM5 expression
    HDAC5 deletion
    SNHG1 deletion
    ROR1 expression
    SRF overexpression
    WNT5A overexpression + FZD2 overexpression
    BRAF V595E
    ERBB3 expression
    HSD3B1 1245A>C
    TSPYL1 P62S
    TMPRSS2-ERG fusion
    AR expression + CYP17A1 expression
    AKR1C3 expression
    MYC amplification
    ETS rearrangment
    ERG overexpression
    ETV1 overexpression
    SLC44A4 expression
    RAC1 deletion
    GAS5 underexpression
    SPINK1 overexpression
    HMGA2 overexpression
    STK11 expression
    ESRP1-RAF1 fusion
    SLC45A3-BRAF fusion
    ZRANB1 overexpression
    BTK overexpression
    TP53 mutation
    CFLAR expression
    BRAF mutation
    GPC1 overexpression
    AKT1 mutation
    KDM4B overexpression
    NRAS G12D
    PHLPP1 deletion
    ZFHX3 deletion
    SPARC amplification
    SOX2 expression
    NOTCH1 deletion
    SLC3A2 expression
    CHD1 deletion
    GPX4 expression
    SLC7A11 expression
    MYCN amplification
    ALCAM elevation
    Chr del(10)
    ATM mutation + CDK12 mutation
    ACSM3 overexpression
    BRCA2 deletion + RB1 deletion
    ACSM1 overexpression
    FLT3 overexpression
    IL2R overexpression
    ARG1 overexpression
    SALL4 positive + POU5F1 positive + KIT positive + PLAA positive
    BRCA2 mutation + CHEK2 mutation
    BRCA2 mutation + CDK12 mutation
    BRCA1 mutation + BRCA2 mutation
    FGF4 amplification + HRAS Q61R + TP53 672+2T>G
    ZEB1 expression
    SNAI1 expression
    ADAMTS1 expression
    KLK4 expression
    KLK2 expression
    KIT mutation
    AR-V7 overexpression
    PIK3CA amplification
    KDM6A amplification
    EZH2 amplification
    DNMT3A amplification
    PREX2 amplification
    PIK3CB amplification
    IRF8 expression
    FOXA mutation
    FSCN1 elevation
    FGF3 amplification + HRAS Q61R + TP53 672+2T>G
    CYP11B1 rs4736349
    FGF19 amplification + HRAS Q61R + TP53 672+2T>G
    NEIL3 deletion
    TP53 R175H
    PTGR1 elevation + HRD
    miR-572 overexpression
    TP53 deletion
    ZG16B positive