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    BIOMARKER:

    PIK3CA amplification

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K




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    Include preclinical:
    Squamous Cell Carcinoma of Head and Neck
    HER2 Positive Breast Cancer
    Chordoma
    Lung Cancer
    Prostate Cancer
    Non Small Cell Lung Cancer
    Gastric Cancer
    everolimus
    alpelisib + tipifarnib
    PF-05212384 + trastuzumab-pkrb
    alpelisib
    LX-086
    tipifarnib
    GDC-0032
    palbociclib + alpelisib
    nivolumab
    GDC-0941
    EZH2 inhibitor
    PI3K inhibitor + EZH2 inhibitor