^
    CANCER:

    Pancreatic Cancer





    Show legend
    Group by Gene:
    Include preclinical:

    gemcitabine
    		0
    DNA synthesis inhibitor
    cisplatin + gemcitabine
    temozolomide
    cisplatin
    5-fluorouracil
    capecitabine
    		1
    Thymidylate synthase inhibitor
    5-fluorouracil + capecitabine
    NUC-3373
    fluorouracil topical
    2
    Thymidylate synthase inhibitor, Topoisomerase I inhibitor
    5-fluorouracil + nanoliposomal irinotecan
    5-fluorouracil + irinotecan
    PD1 inhibitor
    pembrolizumab
    nivolumab
    		3
    PD1 inhibitor
    toripalimab-tpzi
    sintilimab
    dostarlimab-gxly
    PDR001
    4
    PD1 inhibitor, CTLA4 inhibitor
    nivolumab + ipilimumab
    5
    DNA synthesis inhibitor, Bcl2 inhibitor, Tubulin inhibitor
    gemcitabine + albumin-bound paclitaxel
    cisplatin + gemcitabine + albumin-bound paclitaxel
    PARP inhibitor
    olaparib
    		6
    PARP inhibitor
    ABT-888
    rucaparib
    NOV 1401
    erlotinib
    nimotuzumab
    		7
    EGFR inhibitor
    osimertinib
    cetuximab
    gefitinib
    8
    PD-L1 inhibitor, MEK inhibitor
    avelumab + binimetinib
    trametinib
    		9
    MEK inhibitor
    selumetinib
    binimetinib
    IMM-6-415
    D-1553
    JAB-21822
    		10
    KRAS G12C inhibitor
    adagrasib
    sotorasib
    GFH925
    ZG19018
    11
    IGF-1R inhibitor
    AMG 479
    12
    TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor
    larotrectinib
    13
    BRAF inhibitor, BRAF V600E inhibitor
    vemurafenib
    FORE-8394
    IMGS-101
    		14
    Alkylating agent
    OBI-3424
    STAR-001
    15
    MEK1 inhibitor
    cobimetinib
    16
    Gene transference, Thymidine kinase stimulant
    aglatimagene besadenovec
    17
    DNA synthesis inhibitor, DNA cross linking agent
    oxaliplatin
    18
    ZG16B inhibitor
    PBP1510
    19
    PD-L1 inhibitor, Apoptosis stimulant
    atezolizumab + pelareorep
    20
    HER2 inhibitor, HER3 inhibitor
    MCLA-128
    21
    GCR antagonist
    CORT125134
    22
    PDH inhibitor, α-KGDH inhibitor
    devimistat
    23
    Connective tissue growth factor inhibitor
    FG-3019
    24
    CLDN18.2-targeted CAR-T immunotherapy
    CT041
    IBI-345
    selpercatinib
    		25
    RET inhibitor
    BOS-172738
    pralsetinib
    26
    PD-L1 inhibitor, PARP inhibitor
    avelumab + talazoparib
    27
    FGFR inhibitor
    pemigatinib
    28
    PD-L1 inhibitor
    avelumab
    29
    HER2 inhibitor, HER2 dimerization inhibitor
    trastuzumab + pertuzumab
    30
    MEK inhibitor, BRAF inhibitor
    trametinib + dabrafenib
    31
    ALK inhibitor
    alectinib
    crizotinib
    32
    Topoisomerase I inhibitor
    irinotecan
    SSH20
    33
    mTOR inhibitor
    everolimus
    sirolimus
    34
    AKT inhibitor
    MK-2206
    ASTX029
    		35
    ERK2 inhibitor, ERK1 inhibitor
    BVD-523
    ASN007
    36
    PD1 inhibitor, Multi-tyrosine kinase inhibitor
    anlotinib + penpulimab
    anlotinib + sintilimab
    37
    PD1 inhibitor, PARP inhibitor
    nivolumab + ABT-888
    pembrolizumab + olaparib
    38
    PARP1 inhibitor
    BSI 201
    39
    IL1RAP inhibitor
    CAN04
    40
    RAS inhibitor
    RMC-6236
    41
    HER2 inhibitor
    trastuzumab
    42
    Multi-tyrosine kinase inhibitor
    anlotinib
    43
    HER2 inhibitor, EGFR inhibitor
    trastuzumab + erlotinib
    44
    Hyaluronidase stimulant
    PEGPH20
    45
    PRMT5 inhibitor
    AMG 193
    MRTX1133
    		46
    KRAS G12D inhibitor
    RMC-9805
    KS-58
    47
    EGFR inhibitor, HER2 dimerization inhibitor
    erlotinib + pertuzumab
    48
    CLDN18.2 inhibitor
    ZL-1211
    49
    CEA-targeted CAR-T immunotherapy
    A2B530
    50
    MEK inhibitor, BRAF inhibitor, BRAF V600E inhibitor
    trametinib + vemurafenib
    51
    CTLA4 inhibitor
    ipilimumab
    FOLFIRI
    GEM-CAP
    LV5FU2
    CAPOX
    		52
    Chemotherapy
    FOLFIRINOX
    GTX
    FOLFOX
    OFF
    NALIRIFOX
    FOLFIRINOX + GEM-CAP
    53
    Immunotherapy
    Immunotherapy
    54
    T-lymphocyte cell therapy
    T-lymphocyte cell therapy
    Hedgehog cell-signalling pathway inhibitor
    sonidegib
    		55
    Hedgehog cell-signalling pathway inhibitor
    cyclopamine
    GANT61
    GANT1
    56
    MUC16-targeted antibody-drug conjugate
    MUC16-targeted antibody-drug conjugate
    57
    BET inhibitor, CDK inhibitor
    BET inhibitor + CDK inhibitor
    58
    B7-H3-targeted antibody-drug conjugate
    B7-H3-targeted antibody-drug conjugate
    59
    CLDN18.2-targeted antibody-drug conjugate
    CLDN18.2-targeted antibody-drug conjugate
    60
    PTPN11 inhibitor, ERK inhibitor
    PTPN11 inhibitor + ERK inhibitor
    61
    DNA synthesis inhibitor, DNA cross linking agent, Thymidylate synthase inhibitor
    5-fluorouracil + oxaliplatin
    62
    DNA synthesis inhibitor, Folate analog, Thymidylate synthase inhibitor
    gemcitabine + 5-fluorouracil + leucovorin calcium
    63
    DNA synthesis inhibitor, Thymidylate synthase inhibitor
    gemcitabine + capecitabine
    64
    Folate analog, Thymidylate synthase inhibitor
    5-fluorouracil + leucovorin calcium
    65
    Folate analog, Thymidylate synthase inhibitor, Topoisomerase I inhibitor
    5-fluorouracil + leucovorin calcium + nanoliposomal irinotecan
    66
    VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
    sunitinib
    67
    TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
    entrectinib
    68
    FGFR2 inhibitor, FGFR inhibitor, FGFR1 inhibitor, FGFR3 inhibitor, FGFR4 inhibitor
    erdafitinib
    69
    NRP1 modulator, Capillary permeability modulator
    LSTA1
    70
    cRAF inhibitor, MEK inhibitor, BRAF inhibitor
    binimetinib + encorafenib
    71
    PD1 inhibitor, MEK inhibitor
    pembrolizumab + trametinib
    72
    HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
    afatinib
    73
    CTLA4 inhibitor, PARP inhibitor
    ipilimumab + niraparib
    74
    Tubulin polymerization promoter, DNA synthesis inhibitor, Bcl2 inhibitor
    gemcitabine + paclitaxel
    75
    CASP3 stimulant, Ornithine decarboxylase inhibitor, AMD1 inhibitor, PARP inhibitor
    SBP-101
    76
    Telomerase inhibitor, HBsAg release inhibitor, Viral replication inhibitor
    tertomotide
    77
    Notch-3 receptor inhibitor, Notch-2 receptor inhibitor
    OMP-59R5
    78
    MEK inhibitor, BRAF inhibitor, MEK2 inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
    vemurafenib + HL-085
    79
    pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib
    80
    ROS1 inhibitor, PTPN11 inhibitor, ALK inhibitor
    lorlatinib + PF-07284892
    81
    Mesothelin-targeted antibody-drug conjugate, Microtubule inhibitor
    RG7600
    82
    PD-L1 inhibitor, CTLA4 inhibitor
    durvalumab + tremelimumab
    83
    PD-L1 inhibitor, DNA synthesis inhibitor, CTLA4 inhibitor
    durvalumab + gemcitabine + tremelimumab
    84
    Phospholipase A2 inhibitor, DNA synthesis inhibitor, Immunomodulator, Bcl2 inhibitor, Tubulin inhibitor
    gemcitabine + albumin-bound paclitaxel + hydroxychloroquine
    85
    PD1 inhibitor, CSF-1R inhibitor
    nivolumab + BMS-986227
    86
    MEK inhibitor, EGFR inhibitor
    erlotinib + selumetinib
    erlotinib + PD-0325901
    87
    HER2 inhibitor, HER4 inhibitor, EGFR inhibitor, HER2 dimerization inhibitor
    afatinib + pertuzumab
    88
    PD1 inhibitor, IDO1 inhibitor
    nivolumab + BMS-986205
    89
    HER2 inhibitor, DNA synthesis inhibitor, EGFR inhibitor
    trastuzumab + erlotinib + gemcitabine
    90
    TSP1 stimulant, CD36 stimulant
    VT1021
    91
    CLDN18.2 inhibitor, CD3 agonist
    AZD5863
    ASP2138
    92
    CLDN18.2-targeted antibody-drug conjugate, Microtubule inhibitor
    EO-3021
    BMS-986476
    93
    CLDN18.2-targeted antibody-drug conjugate, DNA replication inhibitor
    SOT102
    94
    HER2-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    fam-trastuzumab deruxtecan-nxki
    95
    HER2-targeted antibody-drug conjugate, Microtubule inhibitor
    ado-trastuzumab emtansine
    96
    ROS1 inhibitor, ALK inhibitor
    lorlatinib
    97
    CD137 agonist, HER2 inhibitor
    PRS-343
    98
    ERK inhibitor
    SCH772984
    KO-947
    99
    pan-RAF inhibitor
    LY3009120
    AZ 628
    100
    CDK7 inhibitor
    YPN-005
    101
    Mesothelin-targeted CAR-T immunotherapy
    MSLN-CAR-T cell therapy
    102
    Integrin beta-6 -targeted antibody-drug conjugate, Microtubule inhibitor
    SGN-B6A
    103
    Folate analog
    leucovorin calcium
    104
    SF3B1 inhibitor, RNA splicing modulator
    SSA
    105
    WEE1 inhibitor
    SC0191
    106
    DDX5 degrader
    FL118
    107
    HER2 dimerization inhibitor
    pertuzumab
    108
    CDK4 inhibitor, CDK6 inhibitor
    palbociclib
    109
    KRAS G12C inhibitor, Nicotinamide phosphoribosyltransferase inhibitor, PAK4 inhibitor
    sotorasib + KPT-9274
    110
    Microtubule stabilizer, Tubulin polymerization promoter
    docetaxel
    111
    MAT2A inhibitor
    IDE397
    112
    Apoptosis inducer, GSK3β inhibitor
    BCN057
    113
    SOS1 inhibitor
    BI-3406
    RGT-018
    114
    Ionizing radiation emitter, FAP inhibitor
    AAA614
    115
    ROS1 inhibitor, cRAF inhibitor, Trk inhibitor, MEK inhibitor, ALK inhibitor, BRAF inhibitor, Multi-tyrosine kinase inhibitor
    repotrectinib + VS-6766
    116
    Bcl2 inhibitor, Tubulin inhibitor
    albumin-bound paclitaxel
    117
    Proteasome inhibitor
    ixazomib
    bortezomib
    118
    HER3 inhibitor
    MM-121
    119
    Microtubule stabilizer, Tubulin polymerization promoter, Sortilin inhibitor
    TH 1902
    120
    XPO1 inhibitor, KRAS G12C inhibitor
    sotorasib + selinexor
    121
    XPO1 inhibitor, KRAS inhibitor
    selinexor + MRTX1257
    122
    MDM2 inhibitor
    Nutlin-3
    123
    ATR inhibitor
    BAY 1895344
    124
    c-MET-targeted antibody-drug conjugate, DNA replication inhibitor
    TR1801-ADC
    125
    pan-RAF inhibitor, Src kinase inhibitor
    BAL3833
    126
    MYC inhibitor
    WB100
    127
    STAT3 inhibitor
    BBI608
    128
    IAP inhibitor, PARP inhibitor
    olaparib + APG-1387
    129
    Menin-MLL inhibitor
    BMF-219
    130
    ALPP-targeted antibody-drug conjugate, ALPPL2-targeted antibody-drug conjugate, Microtubule inhibitor
    SGN-ALPV
    131
    Tubulin inhibitor, TROP-2-targeted antibody-drug conjugate
    hIMB1636-MMAE
    132
    ERK2 inhibitor, PTPN11 inhibitor, ERK1 inhibitor
    ASN007 + ERAS-601
    133
    Alkylating agent, undefined TAA/TSA-targeted antibody-drug conjugate
    FGX15-147-based ADC
    134
    Microtubule inhibitor, TROP-2-targeted antibody-drug conjugate, EGFR-targeted antibody-drug conjugate
    DM001
    135
    Bcl-xL degrader, KRAS G12C inhibitor
    sotorasib + DT2216
    136
    BET inhibitor, CDK4 inhibitor, CDK6 inhibitor
    palbociclib + JQ-1
    137
    KRAS G12C inhibitor, MEK2 inhibitor, MEK1 inhibitor
    sotorasib + IMM-1-104
    138
    SOS1 inhibitor, MEK inhibitor
    trametinib + BI-3406
    139
    KRAS G12D inhibitor, BET inhibitor, BRD4 degrader
    MRTX1133 + BI 894999 + dBET6
    140
    BET inhibitor, MEK inhibitor
    BI 894999 + LNP3794
    141
    KRAS G12D degrader
    ASP3082
    142
    KRAS Q61H inhibitor
    RMC-0708
    143
    eIF4A1 inhibitor
    eFT226
    144
    MEK inhibitor, mTOR inhibitor, mTORC2 inhibitor
    trametinib + Torin1
    145
    TNKS inhibitor, PARP inhibitor
    JPI-547
    146
    c-MET-targeted antibody-drug conjugate, EGFR-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    DM005
    147
    MUC1-targeted antibody-drug conjugate, HER3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    DM002
    148
    HDAC inhibitor, Arginine depleter
    panobinostat + pegargiminase
    149
    KRAS G12C inhibitor, PDK1 inhibitor
    sotorasib + VRx-510
    150
    Ornithine decarboxylase inhibitor, COX inhibitor, SSAT activator
    eflornithine / sulindac
    151
    SLC44A4-targeted antibody-drug conjugate, Microtubule inhibitor
    ASG 5ME
    152
    KRAS G12D inhibitor, HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
    afatinib + MRTX1133
    153
    TLR3 agonist, VP35 protein inhibitor
    rintatolimod
    154
    ERK inhibitor, AKT inhibitor
    ONC201
    155
    DR5-targeted antibody-drug conjugate, Microtubule inhibitor
    Oba01
    156
    Microtubule inhibitor, EGFR-targeted antibody-drug conjugate
    HTI-1511
    157
    CEACAM5-targeted antibody-drug conjugate, Microtubule inhibitor
    SAR408701
    158
    GPC-1-targeted antibody-drug conjugate
    anti-GPC-1 ADC
    159
    Microtubule inhibitor, TROP-2-targeted antibody-drug conjugate
    LCB84
    160
    AXL-targeted antibody-drug conjugate, Microtubule inhibitor
    BA3011
    161
    CA6-targeted antibody-drug conjugate, Microtubule inhibitor
    SAR566658
    162
    c-MET-targeted antibody-drug conjugate, Microtubule inhibitor
    SHR-A1403
    163
    Chk1 inhibitor, Chk2 inhibitor, Bcl2 inhibitor, Bcl-xL inhibitor, Bcl-w inhibitor
    ACR-368 + ABT 263
    164
    BRAF inhibitor
    GDC 0879
    165
    PI3Kβ inhibitor, ERK inhibitor
    SCH772984 + AZD8186
    No biomarker
    KRAS wild-type
    KRAS G12C
    KRAS mutation
    KRAS G12D
    KRAS G12R
    KRAS G12V
    KRAS G12
    KRAS amplification
    KRAS exon 2 mutation
    KRAS G13D
    KRAS Q61H
    KRAS G12D + KRAS G12V
    KRAS deletion
    KRAS G12D + Chr del(9)(p21)
    KRAS V12
    TMB-H
    TMB-L
    BRAF V600E
    BRAF V600
    BRAF 486_490 del
    BRAF mutation
    BRAF L485-P490 deletion
    BRAF delNVTAP
    CLDN18.2 expression
    CLDN18.2 positive
    CLDN18.2 underexpression
    CLDN18.2 overexpression
    HER-2 expression
    HER-2 positive
    HER-2 overexpression
    HER-2 amplification
    BRCA2 mutation
    MSI-H/dMMR
    NRG1 mutation
    NRG1 fusion
    MSI-L/dMMR
    BRCA2 1153insT
    BRCA2 I2315T
    NRG1 fusion
    PALB2 mutation
    BRCA1 mutation
    RET fusion
    ELAVL1 expression
    CCL11 overexpression
    ATM mutation
    PD-L1 expression
    FGFR fusion
    SMAD4 positive
    FGFR mutation
    SMAD4 deletion
    PD-L1 overexpression
    SMAD4 mutation
    SMAD4 expression
    NTRK3 fusion
    MSLN expression
    CDA underexpression + SLC29A1 overexpression
    EGFR exon 19 mutation
    BRAF N486-P490del + TP53 V157G
    BRAF mutation + TP53 mutation
    BRIP1 L680fs*9
    FGFR1 T141R
    FGFR1 fusion
    NTRK1 fusion
    EGFR expression
    MSI-H/dMMR + TMB-H + PD-L1 overexpression
    STK11 mutation
    STK11 D194E
    CDA underexpression + SLC29A1 underexpression
    MSI-H/dMMR + TMB-H + PD-L1 negative
    TPR-NTRK1 fusion
    BRIP1 mutation
    MSLN positive
    EGFR T790M
    TROP2 expression + EGFR expression
    EGFR overexpression
    SEL1L-NTRK1 fusion
    ASXL1 mutation + ATM mutation
    MUC16-L
    CCL4-L
    LGALS1 elevation
    ANGPT2-L
    FASLG elevation
    MTAP deletion
    FGFR2 fusion
    SPARC overexpression
    ACTA2 overexpression
    PD-1 overexpression
    MMP2 overexpression
    STAT3 overexpression
    IFNG overexpression
    AKR1C3 overexpression
    PD-L1 expression + TMB-H + FANCA deletion
    MYCN amplification
    ATP1B1-NRG1 fusion
    APP-NRG1 fusion
    PTEN mutation
    BRAF V600E + CDKN2A deletion + MYCN amplification
    KRAS mutation + PD-L1 expression
    BRCA2 mutation + CHEK2 mutation
    PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L
    HRD
    TP53 mutation + KRAS mutation
    TMB-H + PD-L1 underexpression
    KANK4-ALK fusion
    BRCA1 mutation + TMB-H
    TSC2 mutation
    EGFR mutation + TP53 mutation
    CDA underexpression
    KRAS wild-type + BRAF V600E
    PD-L1 expression + MSI-H/dMMR
    MSI-H/dMMR + TMB-H
    KANK4-RAF1 fusion
    GOPC-ROS1 fusion + CTNNB1 S45F
    KRAS G12V + TP53 mutation + APC mutation
    RNF43 mutation
    PIK3CA mutation
    MAP2K2 mutation
    MAP2K1 mutation
    MUC1 underexpression
    ARID1A mutation
    TP53 mutation
    MUC4 underexpression
    C3M/PRO-C3 ratio elevation
    CDH1 expression
    NRAS mutation
    CUX1-BRAF fusion
    IGFBP3 elevation
    IGFBP2-L
    IGF2 elevation
    IGF1 elevation
    CD36 overexpression + CD47 overexpression
    MSH2 mutation
    FANCF mutation
    BRCA1 mutation + BRCA2 mutation
    SLC29A1 overexpression
    EPHB4 expression
    UGT1A1*28 + UGT1A1*6
    HLA-A*02
    NOTCH3 overexpression
    NTRK2 fusion
    CHEK2 mutation
    IL1RAP overexpression
    MAP2K2 H123Q
    PTEN underexpression
    MSI-H/dMMR + TMB-L
    MUC1 overexpression
    MUC16 expression
    TP53 R172H
    MAP2K2 G132S
    MAP2K2 G132D
    GemPred signature
    IFNG gene signature overexpression
    DDR
    HRD signature
    CDKN2A mutation
    CDKN2A deletion
    PDZK1IP1 overexpression
    CIC deletion
    ATXN1L deletion
    SF3B1 K700E
    ERBB3 expression
    DDX5 overexpression
    GLI1 expression
    SIRT1 overexpression
    MUC13 overexpression
    BRCA mutation
    FAM83D overexpression
    VASH2 overexpression
    TLR3 overexpression
    PRKAB1 overexpression
    PRKAG1 overexpression
    ATF6 overexpression
    WFDC3 overexpression
    TNFRSF10B overexpression
    NFKB1 overexpression
    RIPK2 overexpression
    CD276 expression
    SLC3A2-NRG1 fusion
    SORT1 expression
    CEACAM5 expression
    GPC1 overexpression
    TM4SF1 overexpression
    TROP2 expression
    PTGR1 elevation + HRD
    AXL expression
    CAV1 overexpression
    MET overexpression
    AREG overexpression
    MYC overexpression
    GNA13 deletion + KRAS mutation
    KRAS mutation + TP53 mutation + GNA13 deletion
    EREG overexpression
    ALPP expression
    CA6 expression
    USP42 mutation
    ITGB6 expression
    ALPG expression
    BRCA2 mutation + AKR1C3 overexpression
    BRCA1 mutation + AKR1C3 overexpression
    HGF elevation
    GNA13 deletion + TP53 mutation
    PDZK1IP1 expression
    TRPV6 overexpression
    MACC1 overexpression
    RAS mutation
    FGFR1-G3BP2 fusion
    TLE2 overexpression
    ANIB1 overexpression
    LINC01559 underexpression
    TROP2 overexpression
    SLC44A4 expression
    SMAD7 overexpression
    NFATC1 overexpression
    ASS1 underexpression
    EGFR expression + MET expression
    GATA6 underexpression
    FAP expression
    ERBB3 expression + MUC1 expression
    MYC amplification
    SLC4A4-ROS1 fusion
    PTEN mutation + MSI-H/dMMR
    miR-135-b expression
    miR-200-b expression
    miR-139-5p expression
    miR-200-a expression
    CHEK1 overexpression
    BCL2L1 overexpression
    LAMC2 overexpression
    GATA6 expression
    miR-200-c expression
    miR-141 expression
    miR-429 expression
    miR-155 expression
    MET amplification