^
    CANCER:

    Medulloblastoma





    Show legend
    Group by Gene:
    Include preclinical:

    0
    Hedgehog cell-signalling pathway inhibitor
    vismodegib
    sonidegib
    1
    Alkylating agent
    cyclophosphamide
    2
    Topoisomerase II inhibitor, DNA inhibitor
    etoposide oral
    3
    DNA synthesis inhibitor
    temozolomide
    4
    Casein kinase 2 inhibitor
    CX-4945
    5
    Topoisomerase II inhibitor, Alkylating agent, DNA inhibitor
    cyclophosphamide + etoposide oral
    6
    Topoisomerase II inhibitor, Tubulin polymerization promoter, Alkylating agent, DNA inhibitor
    carboplatin + cyclophosphamide + etoposide oral
    7
    Topoisomerase II inhibitor, Alkylating agent, DNA synthesis inhibitor
    cisplatin + cyclophosphamide + etoposide IV
    8
    Alkylating agent, Tubulin polymerization inhibitor, DNA synthesis inhibitor
    cisplatin + vincristine + lomustine
    cisplatin + cyclophosphamide + vincristine
    9
    Alkylating agent, DNA synthesis inhibitor
    carmustine
    10
    Chk1 inhibitor, PARP inhibitor
    olaparib + MK-8776
    11
    SMO protein inhibitor, Hedgehog cell-signalling pathway inhibitor
    IPI 926 oral
    12
    Glutamine antagonist
    JHU395
    13
    CYP51A1 inhibitor
    itraconazole
    14
    PI3K inhibitor, mTOR inhibitor
    AN2025 + sirolimus
    15
    PLK1 inhibitor
    PCM-075
    16
    HDAC inhibitor, PI3K inhibitor
    CUDC-907
    AN2025 + panobinostat
    17
    HDAC inhibitor
    panobinostat
    18
    PI3K inhibitor
    AN2025
    19
    SMO protein inhibitor
    SMO protein inhibitor
    No biomarker
    PTCH1 mutation
    PTCH1 deletion
    MYCN amplification
    SUFU deletion
    MYC expression
    SMO D477G
    SUFU mutation
    SMO D473H
    TP53 mutation
    MYC amplification