BIOMARKER:

KIT exon 13 mutation

A2 | Sensitive

B | Sensitive

C3 | Sensitive

D | Sensitive

A2 | Resistant

B | Resistant

C3 | Resistant

D | Resistant

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Include preclinical:

Drug categories

Tyrosine Kinase Inhibitors

Melanoma

Gastrointestinal Stromal Tumor

imatinib

KIT exon 13 mutation|Melanoma|imatinib

ripretinib

KIT exon 13 mutation|Gastrointestinal Stromal Tumor|ripretinib

nilotinib

KIT exon 13 mutation|Melanoma|nilotinib

regorafenib

KIT exon 13 mutation|Gastrointestinal Stromal Tumor|regorafenib

sunitinib

KIT exon 13 mutation|Melanoma|sunitinib

IDRX-42

KIT exon 13 mutation|Gastrointestinal Stromal Tumor|IDRX-42