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    CANCER:

    Hormone Receptor Positive Breast Cancer





    Show legend
    Group by Gene:
    Include preclinical:

    tamoxifen
    		0
    Estrogen receptor antagonist
    tamoxifen
    tamoxifen
    CDK4 inhibitor + CDK6 inhibitor
    palbociclib
    		1
    CDK4 inhibitor, CDK6 inhibitor
    abemaciclib
    ribociclib
    palbociclib + abemaciclib
    PRT3645
    trastuzumab-qyyp
    trastuzumab-dkst
    trastuzumab-anns
    		2
    HER2 inhibitor
    trastuzumab-dttb
    trastuzumab-pkrb
    tucatinib
    trastuzumab
    Aromatase inhibitor
    		3
    Aromatase inhibitor
    exemestane
    letrozole
    anastrozole
    fulvestrant
    elacestrant
    SAR439859
    		4
    Selective estrogen receptor degrader
    SCR-6852
    SCR6106
    AZD9833
    LY3484356
    PARP inhibitor
    		5
    PARP inhibitor
    talazoparib
    ABT-888
    olaparib
    6
    PIK3CA inhibitor
    alpelisib
    RLY-2608
    7
    RANK ligand inhibitor
    denosumab
    pazopanib
    		8
    Multi-tyrosine kinase inhibitor
    ponatinib
    vandetanib
    9
    VEGF-A inhibitor
    bevacizumab
    10
    Aromatase inhibitor, Selective estrogen receptor degrader
    fulvestrant + anastrozole
    11
    mTOR inhibitor
    everolimus
    12
    Proteasome inhibitor
    ixazomib
    13
    AKT inhibitor
    capivasertib
    14
    Bcl2 inhibitor
    venetoclax
    15
    Selective estrogen receptor modulator
    toremifene
    lasofoxifene
    16
    MDM2 inhibitor
    RAIN-32
    CGM097
    17
    HDAC inhibitor, HDAC1 inhibitor, HDAC2 inhibitor, HDAC3 inhibitor
    entinostat
    18
    Notch inhibitor
    RG4733
    19
    Estrogen receptor antagonist, mTORC1 inhibitor, mTORC2 inhibitor
    tamoxifen + CB-228
    20
    CEBPB antagonist
    ST101
    21
    HER2 inhibitor, HER2 dimerization inhibitor
    trastuzumab + pertuzumab
    22
    Androgen receptor inhibitor
    enzalutamide capsule
    darolutamide
    23
    HER2-targeted antibody-drug conjugate, DNA replication inhibitor
    trastuzumab duocarmazine
    24
    Aurora kinase A inhibitor
    MLN8237
    25
    CDK7 inhibitor
    CT7001
    YPN-005
    26
    Thymidylate synthase inhibitor
    capecitabine
    27
    FGFR inhibitor
    ABSK091
    28
    HER2 inhibitor, HER3 inhibitor
    MCLA-128
    29
    eIF4A1 inhibitor, CDK4 inhibitor, CDK6 inhibitor
    abemaciclib + eFT226
    palbociclib + CR-1-31-B
    30
    Microtubule inhibitor, Notch3-targeted antibody-drug conjugate
    PF-06650808
    31
    Chemotherapy
    ACT
    TCHP
    32
    Aurora kinase inhibitor, WEE1 inhibitor
    WEE1 inhibitor + Aurora kinase inhibitor
    33
    Immunotherapy
    Immunotherapy
    34
    Aromatase inhibitor, CDK4 inhibitor, CDK6 inhibitor
    CDK4 inhibitor + CDK6 inhibitor + Aromatase inhibitor
    35
    Immunotherapy, Selective estrogen receptor degrader
    Immunotherapy + fulvestrant
    36
    FGFR inhibitor, CDK4 inhibitor, CDK6 inhibitor
    palbociclib + BAY 1163877
    37
    Aromatase inhibitor, HDAC inhibitor
    HDAC inhibitor + exemestane
    38
    FGFR inhibitor, VEGFR inhibitor, RET inhibitor, c-KIT inhibitor, PDGFR α antagonist
    lenvatinib
    neratinib
    		39
    HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
    trastuzumab + neratinib
    pyrotinib
    40
    HER2-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    fam-trastuzumab deruxtecan-nxki
    41
    Selective estrogen receptor modulator, Estrogen receptor antagonist
    Z-endoxifen hydrochloride
    42
    Androgen receptor modulator, Selective androgen receptor modulator
    enobosarm
    43
    Aromatase inhibitor, HER2 inhibitor, EGFR inhibitor
    Aromatase inhibitor + trastuzumab + lapatinib
    44
    HER2 inhibitor, EGFR inhibitor
    trastuzumab + lapatinib
    lapatinib
    45
    JAK1 inhibitor, JAK2 inhibitor
    ruxolitinib
    46
    CDK4 inhibitor, PD1 inhibitor, CDK6 inhibitor
    pembrolizumab + palbociclib
    47
    HER2-targeted antibody-drug conjugate, Microtubule inhibitor, HER2 dimerization inhibitor
    pertuzumab + ado-trastuzumab emtansine
    48
    PD-L1 inhibitor, PI3K inhibitor, AKT inhibitor
    atezolizumab + RG7440
    49
    MDMX inhibitor, MDM2 inhibitor
    ALRN-6924
    50
    VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
    sunitinib
    51
    Estrogen receptor antagonist, GnRH agonist
    tamoxifen + goserelin acetate
    52
    CDK4 inhibitor, PI3K inhibitor, mTOR inhibitor, mTORC1 inhibitor, CDK6 inhibitor, mTORC2 inhibitor
    palbociclib + PF-05212384
    53
    Aromatase inhibitor, HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
    pyrotinib + letrozole
    54
    PIK3CA inhibitor, Estrogen receptor antagonist
    tamoxifen + GDC-0032
    55
    DNA synthesis inhibitor, DNA cross linking agent, Apoptosis inhibitor, Microtubule inhibitor
    INT230-6
    56
    PD-L1 inhibitor, CDK4 inhibitor, CDK6 inhibitor
    atezolizumab + abemaciclib
    57
    Aromatase inhibitor, mTOR inhibitor
    everolimus + exemestane
    58
    CDK4 inhibitor, CDK6 inhibitor, Serine protease inhibitor, TMPRSS2 inhibitor
    palbociclib + nafamostat
    59
    Serine protease inhibitor, TMPRSS2 inhibitor
    nafamostat
    60
    CDK4 inhibitor, Sonic hedgehog inhibitor, Stem cell inhibitor, Apoptosis stimulant, CDK6 inhibitor
    palbociclib + GZ17-6.02
    61
    PD1 inhibitor
    nivolumab
    pembrolizumab
    62
    ERK2 inhibitor, ERK1 inhibitor
    BVD-523
    63
    RSK inhibitor
    PMD-026
    64
    Immunostimulant, Free radical stimulant, Oxidative stress enhancer
    SM-88
    65
    Selective estrogen receptor degrader, WEE1 inhibitor
    ZN-c3 + ZN-c5
    66
    CDK4 inhibitor, CDK6 inhibitor, WEE1 inhibitor
    palbociclib + ZN-c3
    67
    WEE1 inhibitor
    ZN-c3
    68
    Estrogen receptor antagonist, CDK4 inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
    palbociclib + OP-1250
    69
    PKC inhibitor
    AEB071
    MK-8776
    LY 2603618
    		70
    Chk1 inhibitor
    CHIR-124
    PD-407824
    PF-00477736
    71
    Chk1 inhibitor, Chk2 inhibitor
    ACR-368
    AZD-7762
    72
    ATR inhibitor
    M6620
    73
    LATS kinase inhibitor
    VT02956
    74
    MYC inhibitor
    MYCi975
    75
    Tubulin polymerization promoter
    carboplatin
    76
    IAP inhibitor
    IGM-9427
    77
    USP8 inhibitor
    DC-U4106
    78
    ATR inhibitor, TROP-2-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    sacituzumab govitecan-hziy + BAY 1895344
    79
    Selective estrogen receptor activator, Cell death stimulant, Unfolded protein response activator
    TEQ103
    80
    PRMT5 inhibitor
    GSK3326595
    81
    PI3K inhibitor
    SB02024
    AN2025
    82
    PD1 inhibitor, PI3Kδ inhibitor
    camrelizumab + linperlisib
    83
    Microtubule inhibitor, LIV-1-targeted antibody-drug conjugate
    BRY812
    84
    CDK4 inhibitor, CDK6 inhibitor, CDK9 inhibitor
    palbociclib + AZD4573
    85
    XPO1 inhibitor, Nuclear export inhibitor
    KPT-8602
    86
    PLK1 inhibitor
    PCM-075
    87
    ATR inhibitor, HER3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    U3-1402 + BAY 1895344
    88
    Androgen receptor antagonist
    apalutamide
    89
    Selective androgen receptor modulator
    EP0062
    90
    Estrogen receptor antagonist, Selective estrogen receptor degrader
    OP-1250
    GDC-9545
    91
    CDK2 inhibitor, CDK4 inhibitor, CDK6 inhibitor
    RGT-419B
    92
    CDK4 inhibitor, CDK6 inhibitor, PDK1 inhibitor
    palbociclib + VRx-510
    ribociclib + VRx-510
    93
    BET inhibitor
    ZEN-3694
    94
    pan-CLK inhibitor, DYRK inhib
    SM08502
    95
    CDK6 degrader, CDK4 degrader
    BTX-9341
    96
    NEDD8 activating enzyme inhibitor
    MLN4924
    97
    CDK4 inhibitor, CDK6 inhibitor, MDM2 inhibitor
    palbociclib + CGM097
    98
    PLK1 inhibitor, PIK3CA inhibitor
    alpelisib + PCM-075
    99
    DRD1 partial agonist
    levo-tetrahydropalmatine
    100
    TrxR inhibitor, AKT inhibitor
    MK-2206 + D9
    101
    SF3B1 inhibitor, RNA splicing modulator
    SSA
    102
    ER-α 36 modulator
    SNG-162
    103
    PI3Kα H1047R mutation inhibitor, CDK4 inhibitor, CDK6 inhibitor
    palbociclib + STX-478
    104
    BET inhibitor, CDK4 inhibitor, CDK6 inhibitor
    palbociclib + ZEN-3694
    abemaciclib + ZEN-3694
    105
    CDK4 inhibitor, CDK6 inhibitor, Bcl2 inhibitor
    palbociclib + APG-2575
    106
    β-catenin inhibitor, Tubulin polymerization promoter, CBP inhibitor, Microtubule inhibitor, Bcl2 inhibitor
    paclitaxel + eribulin mesylate
    107
    PIK3CA inhibitor, CDK4 inhibitor, mTOR inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
    everolimus + alpelisib + abemaciclib + LY3484356
    108
    pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib
    109
    AMPK activator
    metformin
    110
    MCL1 inhibitor, Bcl-xL inhibitor
    S63845 + A-1331852
    111
    PI3K inhibitor, Bcl-xL inhibitor, AKT inhibitor
    RG7440 + A-1331852
    112
    Topoisomerase II inhibitor, Selective estrogen receptor modulator, Selective estrogen receptor α inhibitor, PKCβ inhibitor
    doxorubicin hydrochloride + Z-endoxifen
    113
    HER3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
    U3-1402
    114
    CDK4 inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
    palbociclib + SAR439859
    115
    PIK3CA inhibitor, CDK4 inhibitor, CDK6 inhibitor
    abemaciclib + RLY-2608
    palbociclib + RLY-2608
    116
    CDK19 inhibitor, CDK4 inhibitor, CDK6 inhibitor, CDK8 inhibitor
    palbociclib + Senexin B
    palbociclib + SNX-631
    ER positive
    ER rs2234693
    ER Y537S
    ER Y537N
    ESR1 mutation
    ESR1 rs9322354
    ESR1 rs1801132
    ER mutation
    ER D538G
    ESR1 rs2228480
    ER-L
    ER overexpression
    HR positive
    HER-2 amplification
    HER-2 overexpression
    HER-2 underexpression
    HER-2 mutation
    HER-2 positive
    BRCA1 mutation
    BRCA2 mutation
    BRCA2 overexpression
    BRCA1 L1780P
    HSD17B2 overexpression
    IGFBP7 overexpression
    HR positive + HER-2 positive
    PIK3CA mutation
    PIK3CA H1047R
    PIK3CA E545K
    FGFR1 amplification
    FGFR2 overexpression
    FGFR1 overexpression
    FGFR2 amplification
    FGFR2 mutation
    FGFR1 mutation
    TP53 wild-type
    GATA3 mutation
    SIRT3 expression
    NOS2 underexpression
    EPRS1 expression
    FTO expression
    CTDSP1 expression
    BIN3 expression
    PTCH1 mutation
    NEFH mutation
    USH2A mutation
    PIK3CA mutation + HR positive
    ASXL1 mutation
    SLC3A2-NRG1 fusion
    PIK3CA mutation + ER mutation
    RBPMS expression
    SLBP expression
    KDR V297I
    AKT1 E17K
    CCNB2 expression
    WSB2 expression
    PTEN mutation
    FOXD1 expression
    RET overexpression
    CCNE1 mutation
    LLGL2 underexpression + SLC7A5 underexpression
    SLC7A5 underexpression
    BCL2 positive
    LLGL2 underexpression
    AR positive
    EZH2 rs2302427C>G
    PRMT5 overexpression
    NOTCH3 expression
    TK1 elevation
    PTEN Hypermethylation
    CCNE1 overexpression
    TP53 mutation
    CCNE1 expression
    AKT1 overexpression
    EZH2 rs201135441C>T
    PTEN underexpression
    AR overexpression
    76-gene signature
    SEMA7A overexpression
    ARID1A deletion
    FOXA1 mutation
    MAP3K1 mutation
    SF3B1 K666E
    SF3B1 K666Q
    SF3B1 K700E
    FGF3 mutation
    PLK1 overexpression
    NPY1R underexpression
    SPRED2 deletion
    MYC amplification
    PAK4 deletion
    CDKN2A deletion
    NOTCH4 expression
    NOTCH1 expression + NOTCH4 expression
    NOTCH1 expression
    EGFR overexpression
    APBB1 expression
    LAMTOR5 overexpression
    PPP3CA expression
    SOX2 overexpression
    AGR2 elevation
    TRIM3 overexpression
    SALL4 overexpression
    NODAL overexpression
    IL6R overexpression
    RUNX3 underexpression
    SOX9 overexpression
    35-gene signature
    NCOR2 overexpression
    RB1 deletion
    PC3X elevation
    CDKN2A overexpression
    PRO-C3 elevation
    MDM2 amplification
    MIR497HG deletion
    ERBB3 expression
    AGR2 overexpression
    CCND1 overexpression
    CHID1 overexpression
    CCND1 amplification
    CDK2 overexpression
    HPGD underexpression
    PALB2 mutation
    APC mutation
    AURKA overexpression
    RSF1 amplification
    CDK6 overexpression
    PIK3R1 mutation
    RFC3 overexpression + ER positive