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CANCER:

Gastroesophageal Junction Adenocarcinoma





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Group by Gene:
nivolumab
pembrolizumab
sintilimab
0
PD1 inhibitor
tislelizumab
camrelizumab
pucotenlimab
dostarlimab-gxly
1
DNA synthesis inhibitor, Thymidylate synthase inhibitor
cisplatin + capecitabine
2
Thymidylate synthase inhibitor
5-fluorouracil
capecitabine
3
VEGFR-2 inhibitor
ramucirumab
rivoceranib
HER2 inhibitor
trastuzumab
trastuzumab-dkst
trastuzumab-dttb
4
HER2 inhibitor
trastuzumab-anns
trastuzumab-qyyp
trastuzumab-pkrb
Zercepac (trastuzumab biosimilar)
KN026
Her-VAXX
5
Thymidine phosphorylase inhibitor
trifluridine / tipiracil
6
Topoisomerase I inhibitor
irinotecan
zolbetuximab
7
CLDN18.2 inhibitor
TST001
AB011
8
DNA synthesis inhibitor, DNA cross linking agent, Thymidylate synthase inhibitor
5-fluorouracil + oxaliplatin
capecitabine + oxaliplatin
9
DNA synthesis inhibitor, DNA cross linking agent
oxaliplatin
10
Thymidylate synthase inhibitor, Topoisomerase I inhibitor
5-fluorouracil + irinotecan
11
FGFR2b inhibitor
AMG 552
PD-L1 inhibitor
atezolizumab
12
PD-L1 inhibitor
sugemalimab
durvalumab
avelumab
13
PD1 inhibitor, CTLA4 inhibitor
nivolumab + ipilimumab
cadonilimab
14
DKK1 protein inhibitor
DKN-01
15
TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor
larotrectinib
16
VEGFR-2 inhibitor, HER2 inhibitor
trastuzumab + ramucirumab
17
CLDN18.2-targeted CAR-T immunotherapy
CT041
IBI-345
pembrolizumab + trastuzumab
pembrolizumab + margetuximab
18
HER2 inhibitor, PD1 inhibitor
tislelizumab + ZW25
trastuzumab + camrelizumab
trastuzumab + tislelizumab
19
DKK1 protein inhibitor, PD1 inhibitor
tislelizumab + DKN-01
pembrolizumab + DKN-01
20
HER2 inhibitor, HER2 dimerization inhibitor
trastuzumab + pertuzumab
21
MEK inhibitor, BRAF inhibitor
trametinib + dabrafenib
22
RET inhibitor
selpercatinib
23
VEGFR-2 inhibitor, PD1 inhibitor
camrelizumab + rivoceranib
pembrolizumab + ramucirumab
24
FGFR inhibitor
infigratinib
25
Tubulin polymerization promoter
carboplatin
26
VEGFR-2 inhibitor, HER2 inhibitor, CD47 inhibitor
trastuzumab + ramucirumab + ALX148
27
HER2 inhibitor, HER3 inhibitor
MCLA-128
28
PD-L1 inhibitor, Multi-tyrosine kinase inhibitor
durvalumab + cabozantinib tablet
anlotinib + APL-502
29
VEGFR inhibitor, FGFR1 inhibitor, PD1 inhibitor
toripalimab-tpzi + surufatinib
30
PD1 inhibitor, LAG-3 inhibitor
sintilimab + IBI110
31
PD1 inhibitor, Multi-tyrosine kinase inhibitor
nivolumab + regorafenib
32
PD1 inhibitor, CTLA4 inhibitor, CD47 inhibitor
cadonilimab + AK117
33
ATR inhibitor
M6620
34
HER2 inhibitor, γδ TCR modulator
Undisclosed allogeneic Vγ9Vδ2 HER2-TAC T
35
NK cell stimulant
CYNK-101
FLOT
IP
DP
FP
CAPOX
36
Chemotherapy
CaT
DOF
TCF
FOLFOX
FOLFIRI
TPF
37
Immunotherapy
Immunotherapy
38
Tubulin polymerization promoter, Bcl2 inhibitor
paclitaxel
disitamab vedotin
39
HER2-targeted antibody-drug conjugate, Microtubule inhibitor
JNJ-0683
ado-trastuzumab emtansine
40
Tubulin polymerization promoter, Bcl2 inhibitor, Thymidylate synthase inhibitor
paclitaxel + capecitabine
paclitaxel + 5-fluorouracil
41
Microtubule stabilizer, Tubulin polymerization promoter, Thymidylate synthase inhibitor
carboplatin + docetaxel + 5-fluorouracil
42
Microtubule stabilizer, Tubulin polymerization promoter
docetaxel
43
Microtubule stabilizer, Tubulin polymerization promoter, DNA synthesis inhibitor, Thymidylate synthase inhibitor
cisplatin + docetaxel + 5-fluorouracil
44
Microtubule stabilizer, Tubulin polymerization promoter, Topoisomerase I inhibitor
docetaxel + irinotecan
45
PD-L1 inhibitor, CTLA4 inhibitor
durvalumab + tremelimumab
46
HER2-targeted antibody-drug conjugate, Topoisomerase I inhibitor
fam-trastuzumab deruxtecan-nxki
SHR-A1811
47
CLDN18.2-targeted antibody-drug conjugate, Microtubule inhibitor
AZD0901
48
TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
entrectinib
49
CD137 agonist, HER2 inhibitor
PRS-343
50
VEGFR-2 inhibitor, Caprin-1 inhibitor
ramucirumab + TRK-950
51
PD-L1 inhibitor, HER2 inhibitor, CTLA4 inhibitor
KN046 + KN026
52
PD-L1 inhibitor, VEGF-A inhibitor, TGF-β R2 kinase inhibitor
bevacizumab + SHR-1701
53
TIGIT inhibitor, PD1 inhibitor
zimberelimab + AB154
54
HER2 inhibitor, HER4 inhibitor, PD1 inhibitor, EGFR inhibitor
camrelizumab + pyrotinib
55
Protein synthesis inhibitor, HER2 inhibitor
MT-5111
56
c-MET inhibitor
AMG 102
No biomarker
HER-2 negative
HER-2 positive
HER-2 amplification
HER-2 overexpression
HER-2 expression
HER-2 underexpression
HER-2 positive + HER-2 amplification
HER-2 mutation
HER-2 expression + HER-2 amplification
HER-2 expression + HER-2 D769H
HER-2 expression + HER-2 L869R
MSI-H/dMMR
PD-L1 expression
PD-L1 overexpression
HER-2 negative + PD-L1 expression
CLDN18.2 expression + HER-2 negative
CLDN18.2 positive + HER-2 negative
CLDN18.2 positive
CLDN18.2 overexpression
CLDN18.2 expression
HER-2 positive + PD-L1 expression
PD-L1 expression + HER-2 overexpression
HER-2 amplification + PD-L1 expression
DKK1 overexpression
FGFR2b expression
FGFR2b overexpression
FGFR2 amplification
FGFR2b positive
FGFR2b overexpression + HER-2 negative
NTRK3 fusion
ATR mutation
MSI-H/dMMR + MLH1 negative + PMS2 negative
CAPRIN-1 expression
TP53 mutation
HER-2 expression + TMB-H
TMB-H
PD-1 expression
NTRK1 fusion
NTRK2 fusion
RET fusion
BRAF V600E
ATM mutation
ATRX mutation
IFNG 6-gene signature
MET expression
MET amplification
HER-2 overexpression + PTEN deletion