^




    Show legend
    Group by Gene:
    Include preclinical:

    melphalan hepatic delivery system
    temozolomide
    		0
    DNA synthesis inhibitor
    dacarbazine
    mitomycin
    cisplatin
    bleomycin
    PD1 inhibitor
    		1
    PD1 inhibitor
    pembrolizumab
    nivolumab
    2
    MEK inhibitor
    trametinib
    selumetinib
    3
    CTLA4 inhibitor
    CTLA4 inhibitor
    ipilimumab
    4
    PD1 inhibitor, CTLA4 inhibitor
    nivolumab + ipilimumab
    pembrolizumab + ipilimumab
    5
    gp100 inhibitor, CTLA4 inhibitor
    ipilimumab + tebentafusp-tebn
    6
    Bcl2 inhibitor, Tubulin inhibitor
    albumin-bound paclitaxel
    7
    Alkylating agent
    cyclophosphamide
    8
    MEK inhibitor, BRAF inhibitor
    trametinib + dabrafenib
    9
    gp100 inhibitor
    tebentafusp-tebn
    AEB071
    		10
    PKC inhibitor
    IDE196
    AEB071 + AHT956
    11
    Multi-tyrosine kinase inhibitor
    cabozantinib capsule
    ponatinib
    12
    BRAF inhibitor, BRAF V600E inhibitor
    vemurafenib
    13
    Immunotherapy
    Immunotherapy
    14
    CAR-T immunotherapy
    CAR-T immunotherapy
    15
    FGFR inhibitor, EZH2 inhibitor
    FGFR inhibitor + EZH2 inhibitor
    16
    Chemotherapy
    CaT
    TC
    17
    PD-L1 inhibitor
    PD-L1 inhibitor
    18
    Tubulin polymerization promoter, Bcl2 inhibitor
    paclitaxel
    19
    HDAC inhibitor, HDAC1 inhibitor, PD1 inhibitor, HDAC2 inhibitor, HDAC3 inhibitor
    pembrolizumab + entinostat
    20
    GPNMB-targeted antibody-drug conjugate, Microtubule inhibitor
    CDX-011
    21
    cRAF inhibitor, PD1 inhibitor, MEK inhibitor, BRAF inhibitor
    pembrolizumab + binimetinib + encorafenib
    22
    THF dehydrogenase inhibitor, Arginine depleter, DNA synthesis inhibitor, Thymidylate synthase inhibitor
    cisplatin + pemetrexed + pegargiminase
    23
    MEK inhibitor, PI3K inhibitor, mTOR inhibitor
    trametinib + GSK2126458
    24
    MEK inhibitor, mTOR inhibitor
    selumetinib + AZD8055
    25
    MEK2 inhibitor, MEK1 inhibitor
    REC-4881
    U0126
    26
    GNAQ inhibitor, NMT-1 inhibitor, NLRP3 inhibitor, ARF6 inhibitor
    Tris DBA
    27
    Gαq-11 protein inhibitor
    FR900359
    28
    Topoisomerase I inhibitor
    camptothecin nanosomal
    29
    MEK inhibitor, PKC inhibitor
    binimetinib + AEB071
    PD-0325901 + AEB071
    30
    MDM2 inhibitor, PKC inhibitor
    AEB071 + CGM097
    31
    Reactive oxygen species stimulant, Photosensitizer
    verteporfin
    32
    mTOR inhibitor, PKC inhibitor
    everolimus + AEB071
    33
    BET inhibitor
    JQ-1
    34
    Phospholipase A2 inhibitor, MEK inhibitor, Immunomodulator
    trametinib + hydroxychloroquine
    35
    PI3K inhibitor, PKCβ inhibitor, AKT inhibitor
    enzastaurin
    36
    CDK inhibitor
    SNS-032
    37
    HDAC inhibitor
    JNJ 26481585
    38
    Topoisomerase II inhibitor
    zoptarelin doxorubicin
    39
    MEK inhibitor, Reactive oxygen species stimulant, Apoptosis stimulant, HSP70 stimulant
    binimetinib + STA-4783
    40
    Reactive oxygen species stimulant, Apoptosis stimulant, HSP70 stimulant
    STA-4783
    41
    EphB4 inhibitor
    BHG712
    42
    CXCL12 inhibitor, Farnesyl transferase inhibitor
    tipifarnib
    43
    Aurora kinase B inhibitor, Aurora kinase C inhibitor
    NMI-900
    44
    DNA synthesis inhibitor, DNA-directed DNAP inhibitor
    cytarabine
    45
    PRMT5 inhibitor
    EPZ015666
    46
    MEK inhibitor, Gαq-11 protein inhibitor, Purinergic receptor P2Y12 inhibitor
    MEK inhibitor + YM-254890
    No biomarker
    HLA-A*02:01
    BRAF V600E
    BRAF V600
    BRAF mutation
    GNAQ mutation
    GNAQ Q209L
    GNAQ G48V
    GNAQ Q209P
    GNAQ R183Q
    LDH-L
    GNA11 Q209L
    GNA11 mutation
    MBD4 mutation
    MBD4 L563T
    LDH elevation
    MBD4 deletion
    GNAQ G48L + FGFR4 C172G
    GOLM1 overexpression
    GNAQ mutation + GNA11 mutation
    ASS1 negative
    PCSK9 underexpression
    CXCL10 elevation
    MLANA expression + SOX10 expression
    IL6 elevation
    GPNMB expression
    NRAS overexpression
    DDX43 overexpression
    BRD4 overexpression
    B4GALNT1 expression
    PRMT5 overexpression
    KDELR3 overexpression
    GNRH1 expression
    CDK9 overexpression
    CDK7 overexpression
    BAP1 mutation
    BAP1 deletion
    CYSLTR2 L129Q
    KRAS overexpression