^
    CANCER:

    Endocrine Cancer





    Show legend
    Group by Gene:
    Include preclinical:

    cabozantinib capsule
    vandetanib
    		0
    Multi-tyrosine kinase inhibitor
    cabozantinib tablet
    regorafenib
    ponatinib
    AMG 706
    cisplatin
    		1
    DNA synthesis inhibitor
    streptozocin
    dacarbazine
    temozolomide
    selpercatinib
    pralsetinib
    RET inhibitor
    BOS-172738
    EP0031
    		2
    RET inhibitor
    SY-5007
    TAS0953 / HM06
    LDD-2633
    XMD15-44
    HG-6-63-01
    TY-1091
    pembrolizumab
    		3
    PD1 inhibitor
    PD1 inhibitor
    tislelizumab
    4
    TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor
    larotrectinib
    5
    Steroid receptor inhibitor
    mitotane
    6
    RANK ligand inhibitor
    denosumab
    7
    DNA synthesis inhibitor, Steroid receptor inhibitor
    mitotane + streptozocin
    doxorubicin hydrochloride
    		8
    Topoisomerase II inhibitor
    teniposide
    mitoxantrone
    9
    Tubulin polymerization promoter, Bcl2 inhibitor
    carboplatin + paclitaxel
    paclitaxel
    selumetinib
    		10
    MEK inhibitor
    trametinib
    CI-1040
    11
    BRAF inhibitor, BRAF V600E inhibitor
    vemurafenib
    FORE-8394
    12
    MEK inhibitor, BRAF inhibitor
    trametinib + dabrafenib
    BRAF inhibitor + MEK inhibitor
    13
    mTOR inhibitor
    everolimus
    sirolimus
    14
    ICAM-1-targeted CAR-T immunotherapy
    AIC100
    15
    mTOR inhibitor, Multi-tyrosine kinase inhibitor
    everolimus + vandetanib
    16
    ALK inhibitor
    crizotinib
    alectinib
    BRAF inhibitor
    		17
    BRAF inhibitor
    dabrafenib
    PLX4720
    18
    PD1 inhibitor, Multi-tyrosine kinase inhibitor
    anlotinib + sintilimab
    19
    MEK inhibitor, mTOR inhibitor, BRAF inhibitor
    trametinib + dabrafenib + everolimus
    20
    PD-L1 inhibitor, LAG-3 inhibitor
    FS118
    21
    PD1 inhibitor, CTLA4 inhibitor
    nivolumab + ipilimumab
    22
    PD1 inhibitor, BRAF inhibitor, BRAF V600E inhibitor
    nivolumab + vemurafenib
    23
    PD1 inhibitor, MEK inhibitor, BRAF inhibitor
    pembrolizumab + trametinib + dabrafenib
    trametinib + dabrafenib + sintilimab
    24
    EGFR inhibitor
    erlotinib
    25
    VEGFR-2 inhibitor
    rivoceranib
    26
    TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor antagonist
    AB-106
    27
    IL-6 inhibitor
    siltuximab
    28
    VEGFR-2 inhibitor, PD1 inhibitor
    camrelizumab + rivoceranib
    29
    pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib
    30
    FGFR inhibitor, VEGFR inhibitor, RET inhibitor, c-KIT inhibitor, PDGFR α antagonist
    lenvatinib
    31
    Topoisomerase II inhibitor, Microtubule stabilizer, Tubulin polymerization promoter
    docetaxel + doxorubicin hydrochloride
    32
    Topoisomerase II inhibitor, Tubulin polymerization promoter
    carboplatin + doxorubicin hydrochloride + etoposide IV
    carboplatin + etoposide IV
    33
    Topoisomerase II inhibitor, DNA synthesis inhibitor, Steroid receptor inhibitor
    cisplatin + doxorubicin hydrochloride + etoposide IV + mitotane
    cisplatin + etoposide IV + mitotane
    34
    Topoisomerase II inhibitor, Tubulin polymerization promoter, Steroid receptor inhibitor
    carboplatin + etoposide IV + mitotane
    carboplatin + doxorubicin hydrochloride + etoposide IV + mitotane
    35
    Topoisomerase II inhibitor, DNA synthesis inhibitor
    cisplatin + doxorubicin hydrochloride + etoposide IV
    cisplatin + etoposide IV
    36
    PD-L1 inhibitor, MEK1 inhibitor
    atezolizumab + cobimetinib
    37
    EZH2 inhibitor
    EZH2 inhibitor
    38
    Immunotherapy
    Immunotherapy
    39
    Chemotherapy
    CaT
    EDP
    40
    FGFR inhibitor, VEGFR inhibitor, RET inhibitor, PD1 inhibitor, c-KIT inhibitor, PDGFR α antagonist
    pembrolizumab + lenvatinib
    41
    TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
    entrectinib
    42
    BRAF inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
    vemurafenib + cobimetinib
    43
    pan-RAF inhibitor, EGFR inhibitor
    BGB-283
    44
    BRAF inhibitor, BRAF V600E inhibitor, Cytochrome P450 inhibitor
    FORE-8394 + cobicistat
    45
    MEK inhibitor, BRAF inhibitor, MEK2 inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
    vemurafenib + HL-085
    46
    PD-L1 inhibitor, BRAF inhibitor, BRAF V600E inhibitor
    atezolizumab + vemurafenib
    47
    pan-RAF inhibitor, CXCL12 inhibitor, Farnesyl transferase inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib + tipifarnib
    48
    RET inhibitor, Src kinase inhibitor
    TPX-0046
    49
    FGFR2 inhibitor, FGFR inhibitor, FGFR1 inhibitor, FGFR3 inhibitor, FGFR4 inhibitor
    erdafitinib
    50
    VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
    sunitinib
    51
    VEGFR-2 inhibitor, PI3K inhibitor, mTOR inhibitor, BRAF inhibitor
    RTB101 + RAF265
    52
    CDK4 inhibitor, CDK6 inhibitor, CDK9 inhibitor
    DSP-2033
    dasatinib + selumetinib
    		53
    Bcr-abl tyrosine kinase inhibitor, MEK inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    trametinib + dasatinib
    dasatinib + CI-1040
    54
    MEK inhibitor, MDM2 inhibitor
    selumetinib + KRT-232
    55
    Aurora kinase inhibitor, MEK inhibitor, SRC-family kinase (SFK) inhibitor
    CI-1040 + SU6656
    56
    MEK inhibitor, Src kinase inhibitor
    CI-1040 + PP2
    57
    HER2 inhibitor, BRAF inhibitor, EGFR inhibitor
    lapatinib + PLX4720
    58
    JAK1 inhibitor, JAK2 inhibitor
    AZD1480
    AZ 628
    		59
    pan-RAF inhibitor
    RG6185
    LY3009120
    60
    EphA2 receptor antagonist
    ALW-II-41-27
    61
    Aurora kinase A inhibitor
    MLN8237
    62
    RET inhibitor, mTORC1 inhibitor, FLT3 inhibitor, mTORC2 inhibitor
    CB-228 + AST-487
    63
    DNA topoisomerase inhibitor
    rubitecan
    64
    CDK4 inhibitor, CDK6 inhibitor
    palbociclib
    65
    Topoisomerase II inhibitor, DNA inhibitor
    etoposide oral
    66
    DNA topoisomerase inhibitor, RNA synthesis inhibitor
    pirarubicin
    67
    Topoisomerase II inhibitor, DNA cross linking agent
    idarubicin hydrochloride
    68
    Topoisomerase II inhibitor, DNA intercalator
    daunorubicin
    69
    DNA intercalator
    aclarubicin
    70
    Aurora kinase inhibitor, Steroid receptor inhibitor
    mitotane + AMG 900
    71
    Aurora kinase inhibitor
    AMG 900
    72
    ERK inhibitor, BRAF inhibitor
    dabrafenib + SCH772984
    73
    AKT inhibitor
    MK-2206
    74
    RET inhibitor, FLT3 inhibitor
    AST-487
    75
    mTOR inhibitor, AKT inhibitor
    temsirolimus + MK-2206
    76
    DNA synthesis inhibitor, Thymidylate synthase inhibitor
    temozolomide + capecitabine
    77
    P21-activated kinase inhibitor
    FRAX597
    78
    mTOR inhibitor, mTORC2 inhibitor
    Torin1
    79
    Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib
    80
    ERK2 inhibitor, MEK inhibitor
    BAY86-9766
    81
    ERK2 inhibitor, MEK inhibitor, mTOR inhibitor
    temsirolimus + BAY86-9766
    82
    HER2 inhibitor, EGFR inhibitor, Multi-tyrosine kinase inhibitor
    AEE788
    83
    BRAF inhibitor, Multi-tyrosine kinase inhibitor
    ponatinib + PLX4720
    84
    Tubulin polymerization promoter
    carboplatin
    85
    Jumonji H3K27 demethylase inhibitor
    GSKJ4
    86
    MEK inhibitor, BRAF inhibitor, WEE1 inhibitor
    trametinib + dabrafenib + AZD1775
    87
    WEE1 inhibitor
    AZD1775
    88
    pan-RAF inhibitor, RIPK3 inhibitor, RIPK1 inhibitor
    TAK‐632
    89
    Aurora kinase inhibitor, SRC-family kinase (SFK) inhibitor
    SU6656
    90
    VEGFR-2 inhibitor, BRAF inhibitor
    RAF265
    91
    Src kinase inhibitor
    PP2
    92
    VEGFR inhibitor, BRAF inhibitor
    PLX4720 + axitinib
    dabrafenib + axitinib
    93
    Bcr-abl tyrosine kinase inhibitor, ERK inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib + SCH772984
    No biomarker
    RET M918T
    RET mutation
    RET Y900_S904delinsP
    RET fusion
    RET V804*
    RET C634*
    RET C634R
    RET V804M
    RET V804L
    RET positive
    RET C620R
    RET C618R
    RET C634F
    RET L629P
    RET D631_R635delinsG
    RET V637R
    RET exon 11 deletion
    RET V804M + M918T
    RET C634W
    RET V804M + RET M918T + RET G810 + RET Y806
    RET C634Y
    RET rearrangement
    BRAF V600E
    BRAF V600
    BRAF mutation
    BRAF T1799A
    NRAS mutation
    NRAS Q61K
    NRAS Q61R
    NTRK1 fusion
    NTRK1 overexpression
    NTRK1 positive
    KRAS mutation
    BRAF V600E + PD-L1 expression
    PD-L1 expression + BRAF negative
    BRAF V600E + PD-L1 expression
    KRAS G12R
    ALK1 rearrangement
    ATM S978fs*12
    PD-L1 overexpression
    TMB-H
    ATM L804fs*4
    PD-L1 expression
    PIK3CA H1047R
    NTRK3 fusion
    NTRK2 fusion
    TMB-L
    PIK3CA Q546K
    TMB-L + PD-L1 underexpression
    NTRK2 positive
    NTRK3 positive
    PD-L1 negative + TMB-L
    ALK1 overexpression
    EGFR overexpression
    EGFR L858R
    PIK3CA mutation
    EGFR mutation
    PIK3CA E545K
    GLI3 overexpression
    TPM3-NTRK1 fusion
    PAX8 positive
    NCOA4-RET fusion
    PD-L1 expression + NRAS Q61R + BRAF D594N
    CCDC6-RET fusion
    NF2 mutation
    NF1 mutation
    MSH2 mutation
    TERT positive + PD-L1 expression
    SDHB mutation
    HRAS Q61R + TP53 P278S + PD-L1 overexpression
    MSH2 mutation + MSH6 mutation
    CCDC6-ALK fusion
    MGMT underexpression
    STK11 mutation
    RRM1 underexpression
    CCDC6‐RET fusion + TERT promotor mutation
    ATRX mutation + TP53 mutation + PTEN mutation
    BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L
    GLI1 overexpression
    RET M918T + ATM L804fs*4 + ATM S978fs*12
    FGFR3-TACC3 fusion
    PDGFRB overexpression
    GLI2 overexpression
    MSI-H/dMMR
    MSH2 deletion + MSH6 deletion
    RAS mutation
    MTOR F2108L
    RET-PTC1 rearrangement
    HRAS G13R
    FGFR1 overexpression
    PTEN mutation
    KRAS G12V + BRAF V600E
    NRAS Q61K + BRAF V600E
    NRAS G13D + BRAF V600E
    PTCH1 rearrangement
    MYC overexpression
    TERT mutation + BRAF V600E
    HMGB1 underexpression
    CASP12 overexpression
    CYCS overexpression
    CASP8 overexpression
    CASP3 overexpression
    WEE1 underexpression
    ASXL1 overexpression
    BRAF V600E + TERT mutation
    miR-340 expression
    miR-361 expression
    miR-363 expression
    miR-3651 expression
    miR-3917 expression
    miR-409 expression
    miR-4467 expression
    miR-4473 expression
    miR-449c expression
    miR-425 expression
    miR-4664 expression
    miR-4745 expression
    miR-504 expression
    miR-543 expression
    miR-584 expression
    miR-660 expression
    miR-664a expression
    miR-7 expression
    miR-760 expression
    miR-92a-1 expression
    miR-424 expression
    miR-100 expression
    miR-1293 expression
    miR-96 expression
    miR-99a expression
    miR-320a expression
    miR-490 expression
    TOP2A overexpression
    CDK1 overexpression
    CDK4 overexpression
    AURKB overexpression
    AURKA overexpression
    MET overexpression
    CDK2 overexpression
    EZH2 overexpression
    HRAS G13R
    miR-769 expression
    HRAS G12V
    miR-335 expression
    miR-331 expression
    miR-328 expression
    miR-3200 expression
    miR-3187 expression
    miR-30d expression
    miR-30b expression
    miR-27b expression
    miR-27a expression
    miR-24-2 expression
    miR-23b expression
    miR-23a expression
    miR-2277 expression
    miR-21 expression
    miR-192 expression
    miR-185 expression
    miR-184 expression
    miR-155 expression
    miR-146a expression
    miR-132 expression
    miR-1301 expression
    miR-1291 expression
    miR-1287 expression
    miR-128 expression
    PTEN R130del
    TSC2 Q1178X