^
    CANCER:

    Acute Promyelocytic Leukemia





    Show legend
    Group by Gene:
    Include preclinical:

    0
    Apoptosis stimulant
    arsenic trioxide
    1
    Bcl2 inhibitor
    venetoclax
    2
    CD33-targeted antibody-drug conjugate, DNA replication inhibitor
    gemtuzumab ozogamicin
    3
    Topoisomerase II inhibitor, DNA synthesis inhibitor, DNA-directed DNAP inhibitor, DNA intercalator
    cytarabine + daunorubicin
    4
    Topoisomerase II inhibitor, DNA synthesis inhibitor, DNA cross linking agent, DNA-directed DNAP inhibitor
    cytarabine + idarubicin hydrochloride
    5
    Retinoic acid receptor agonist, Telomerase inhibitor, Cytotoxic T lymphocyte stimulant, Apoptosis stimulant
    tretinoin + arsenic trioxide
    6
    Chemotherapy
    DCAG
    7
    Topoisomerase II inhibitor, DNA synthesis inhibitor, DNA cross linking agent, DNA-directed DNAP inhibitor, Apoptosis stimulant, Ribonucleotide reductase inhibitor
    cytarabine + idarubicin hydrochloride + arsenic trioxide + hydroxyurea
    8
    HDAC inhibitor, MAPK inhibitor, HDAC10 inhibitor, HDAC1 inhibitor, PI3K inhibitor, HDAC2 inhibitor, AKT inhibitor, HDAC3 inhibitor
    chidamide
    No biomarker
    PML-RARA fusion
    PML-RARA T285I
    STAT5b-RARA fusion
    FLT3-ITD mutation + PML-RARA fusion + WT1 overexpression
    Chr t(15;17)
    ZBTB16-RARA fusion
    NPM-RARA fusion