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    Association details:
    Biomarker:ZNF649-AS1 overexpression
    Cancer:Breast Cancer
    Drug:Herceptin (trastuzumab) (HER2 inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Mol Ther
    Title:

    lncRNA ZNF649-AS1 Induces Trastuzumab Resistance by Promoting ATG5 Expression and Autophagy

    Published date:
    07/20/2020
    Excerpt:
    Increased expression of ZNF649-AS1 was associated with a poorer response and shorter survival time of breast cancer patients.
    DOI:
    10.1016/j.ymthe.2020.07.019