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Association details:
Biomarker:YWHAE-NUTM2A translocation
Cancer:Endometrial Cancer
Regimen:AIM (doxorubicin hydrochloride + ifosfamide + )
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
New
Title:

YWHAE-Rearranged High-Grade Endometrial Stromal Sarcoma: Two-Center Case Series and Response to Chemotherapy

Excerpt:
Seven patients were identified with YWHAE-rearranged HG-ESS...Median follow-up for the cohort was 27 months (range 6–123)...One patient (Case-5) presenting with FIGO Stage IVB disease received chemotherapy with doxorubicin, ifosfamide and mesna (AIM) followed by liposomal doxorubicin resulting in a radiographic CR, with subsequent hysterectomy and salpingo-oophorectomy that revealed no viable tumor.
DOI:
10.1016/j.ygyno.2017.03.021