^
    Back
    Association details:
    Biomarker:YWHAE-NUTM2A translocation
    Cancer:Endometrial Cancer
    Regimen: (doxorubicin hydrochloride + ifosfamide + methotrexate IV)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    Gynecol Oncol
    Title:

    YWHAE-Rearranged High-Grade Endometrial Stromal Sarcoma: Two-Center Case Series and Response to Chemotherapy

    Excerpt:
    Seven patients were identified with YWHAE-rearranged HG-ESS...Median follow-up for the cohort was 27 months (range 6–123)...One patient (Case-5) presenting with FIGO Stage IVB disease received chemotherapy with doxorubicin, ifosfamide and mesna (AIM) followed by liposomal doxorubicin resulting in a radiographic CR, with subsequent hysterectomy and salpingo-oophorectomy that revealed no viable tumor.
    DOI:
    10.1016/j.ygyno.2017.03.021